DataVXAdvanced Functional MaterialsPaper
journal article·2020-09Open access

Magnetothermal Multiplexing for Selective Remote Control of Cell Signaling

Junsang Moon, Michael G. Christiansen, Siyuan Rao, Colin Marcus, David C. Bono, Dekel Rosenfeld, Danijela Gregurec, Georgios Varnavides, Po‐Han Chiang, Seongjun Park, Polina Anikeeva

Advanced Functional Materials· Volume 30· Issue 36
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Source abstract

Abstract

Abstract Magnetic nanoparticles have garnered sustained research interest for their promise in biomedical applications including diagnostic imaging, triggered drug release, cancer hyperthermia, and neural stimulation. Many of these applications make use of heat dissipation by ferrite nanoparticles under alternating magnetic fields, with these fields acting as an externally administered stimulus that is either present or absent, toggling heat dissipation on and off. Here, an extension of this concept, magnetothermal multiplexing is demonstrated, in which exposure to alternating magnetic fields of differing amplitude and frequency can result in selective and independent heating of magnetic nanoparticle ensembles. The differing magnetic coercivity of these particles, empirically characterized by a custom high amplitude alternating current magnetometer, informs the systematic selection of a multiplexed material system. This work culminates in a demonstration of magnetothermal multiplexing for selective remote control of cellular signaling in vitro.
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Research context

Nanomaterials

OpenAlex topics: Characterization and Applications of Magnetic Nanoparticles · Advanced Thermodynamics and Statistical Mechanics · Magnetic properties of thin films

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Materials Science and Engineering Massachusetts Institute of Technology Cambridge MA 02142 USA

Research Laboratory of Electronics Massachusetts Institute of Technology Cambridge MA 02139 USA

McGovern Institute for Brain Research Massachusetts Institute of Technology Cambridge MA 02139 USA

Department of Health Sciences and Technology Swiss Federal Institute of Technology Zürich 8093 Switzerland

Computer Science and Artificial Intelligence Lab Massachusetts Institute of Technology Cambridge MA 02139 USA

Institute of Biomedical Engineering National Chiao Tung University 1001 University Road Hsinchu 30010 Taiwan

Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology Cambridge MA 02142 USA

Department of Bio and Brain Engineering Korea Advanced Institute of Science and Technology Daejeon 34141 Republic of Korea

Department of Brain and Cognitive Sciences Massachusetts Institute of Technology Cambridge MA 02139 USA

Funding

Defense Advanced Research Projects Agency · National Institutes of Health · National Science Foundation

References (35)

Show source-provided references
1. 10.1002/anie.20130655710.1002/anie.201306557 ↗
2. 10.1038/nnano.2010.12510.1038/nnano.2010.125 ↗
3. 10.1126/science.126182110.1126/science.1261821 ↗
4. 10.1063/1.487984210.1063/1.4879842 ↗
5. 10.1063/1.355158210.1063/1.3551582 ↗
6. 10.1016/j.jmmm.2006.10.115610.1016/j.jmmm.2006.10.1156 ↗
7. 10.1038/nnano.2011.9510.1038/nnano.2011.95 ↗
8. O'Handley R. C. · 2000
9. 10.1021/jp060577o10.1021/jp060577o ↗
10. 10.1103/PhysRev.110.134110.1103/PhysRev.110.1341 ↗
11. 10.1143/PTP.23.105510.1143/PTP.23.1055 ↗
12. 10.1016/j.neuron.2012.12.01610.1016/j.neuron.2012.12.016 ↗
13. 10.1523/JNEUROSCI.2601-12.201210.1523/JNEUROSCI.2601-12.2012 ↗
14. 10.1021/nn403526610.1021/nn4035266 ↗
15. 10.1021/ja067184n10.1021/ja067184n ↗
16. 10.1088/0957-0233/25/11/11570210.1088/0957-0233/25/11/115702 ↗
17. 10.1063/1.489565610.1063/1.4895656 ↗
18. 10.1016/j.jmmm.2013.11.02110.1016/j.jmmm.2013.11.021 ↗
19. 10.1016/j.jmmm.2016.08.01510.1016/j.jmmm.2016.08.015 ↗
20. 10.1109/LMAG.2017.276852110.1109/LMAG.2017.2768521 ↗
21. 10.1063/1.499935810.1063/1.4999358 ↗
22. 10.1109/TMAG.2011.215747210.1109/TMAG.2011.2157472 ↗
23. 10.1021/nl400188q10.1021/nl400188q ↗
24. 10.1039/C5NR03777H10.1039/C5NR03777H ↗
25. 10.1103/PhysRevB.100.11540210.1103/PhysRevB.100.115402 ↗
26. 10.1016/j.bpj.2020.01.02810.1016/j.bpj.2020.01.028 ↗
27. 10.1126/sciadv.aaz373410.1126/sciadv.aaz3734 ↗
28. 10.7554/eLife.2706910.7554/eLife.27069 ↗
29. 10.1002/mrm.2172110.1002/mrm.21721 ↗
30. 10.1038/3980710.1038/39807 ↗
31. 10.1002/adfm.20160218910.1002/adfm.201602189 ↗
32. 10.1021/acs.nanolett.6b0267010.1021/acs.nanolett.6b02670 ↗
33. 10.1021/acsnano.9b0806110.1021/acsnano.9b08061 ↗
34. 10.1002/smll.20180256310.1002/smll.201802563 ↗
35. 10.1021/acs.nanolett.5b0476110.1021/acs.nanolett.5b04761 ↗