DataVXAdvanced Functional MaterialsPaper
journal article·2019-05Open access

Multicore Liquid Perfluorocarbon‐Loaded Multimodal Nanoparticles for Stable Ultrasound and 19F MRI Applied to In Vivo Cell Tracking

Olga Koshkina, Guillaume Lajoinie, Francesca Baldelli Bombelli, Edyta Swider, Luis J. Cruz, Paul B. White, Ralf Schweins, Yusuf Dolen, Eric A. W. van Dinther, N. Koen van Riessen, Sarah E. Rogers, Remco Fokkink, Ilja K. Voets, Ernst R. H. van Eck, Arend Heerschap, Michel Versluis, Chris L. de Korte, Carl G. Figdor, I. Jolanda M. de Vries, Mangala Srinivas

Advanced Functional Materials· Volume 29· Issue 19
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Abstract

Abstract Ultrasound is the most commonly used clinical imaging modality. However, in applications requiring cell‐labeling, the large size and short active lifetime of ultrasound contrast agents limit their longitudinal use. Here, 100 nm radius, clinically applicable, polymeric nanoparticles containing a liquid perfluorocarbon, which enhance ultrasound contrast during repeated ultrasound imaging over the course of at least 48 h, are described. The perfluorocarbon enables monitoring the nanoparticles with quantitative 19F magnetic resonance imaging, making these particles effective multimodal imaging agents. Unlike typical core–shell perfluorocarbon‐based ultrasound contrast agents, these nanoparticles have an atypical fractal internal structure. The nonvaporizing highly hydrophobic perfluorocarbon forms multiple cores within the polymeric matrix and is, surprisingly, hydrated with water, as determined from small‐angle neutron scattering and nuclear magnetic resonance spectroscopy. Finally, the nanoparticles are used to image therapeutic dendritic cells with ultrasound in vivo, as well as with 19F MRI and fluorescence imaging, demonstrating their potential for long‐term in vivo multimodal imaging.
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Research context

PolymersNanomaterials

OpenAlex topics: Ultrasound and Hyperthermia Applications · Photoacoustic and Ultrasonic Imaging · Electron Spin Resonance Studies

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Tumor Immunology Radboud Institute for Molecular Life Sciences (RIMLS) Geert Grooteplein Zuid 28 6525 GA Nijmegen The Netherlands

Physical Chemistry of Polymers Max Planck Institute for Polymer Research Ackermannweg 10 55128 Mainz Germany

Physics of Fluids Group Technical Medical (TechMed) Centre and MESA+ Institute for Nanotechnology University of Twente Drienerlolaan 5 7522 NB Enschede The Netherlands

Laboratory of Supramolecular and BioNano Materials (SupraBioNanoLab) Department of Chemistry, Materials, and Chemical Engineering “Giulio Natta,” Politecnico di Milano Via Luigi Mancinelli 7 20131 Milan Italy

Translational Nanobiomaterials and Imaging Department of Radiology Leiden University Medical Centre Albinusdreef 2 2333 ZA Leiden The Netherlands

Institute for Molecules and Materials Radboud University Heyendaalseweg 135 6525 AJ Nijmegen The Netherlands

Institut Laue – Langevin DS/LSS, 71 Avenue des Martyrs, CS 20 156 38042 Grenoble CEDEX 9 France

ISIS Pulsed Neutron and Muon Source, Science and Technology Facilities Council Rutherford Appleton Laboratory Harwell Oxford OX11 0QX UK

Department of Agrotechnology and Food Sciences Physical Chemistry and Soft Matter Wageningen University 6708 WE Wageningen Netherlands

Laboratory of Self‐Organizing Soft Matter Laboratory of Macromolecular and Organic Chemistry Department of Chemical Engineering and Chemistry and Institute for Complex Molecular Systems Eindhoven University of Technology De Rondom 70 5612 AP Eindhoven The Netherlands

Department of Radiology and Nuclear Medicine Radboudumc Geert Grooteplein Zuid 10 6525 GA Nijmegen The Netherlands

Funding

Netherlands Organization for International Cooperation in Higher Education · European Research Council

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