journal article·2015-10Open access

Gadolinium‐Doped Iron Oxide Nanoprobe as Multifunctional Bioimaging Agent and Drug Delivery System

Guilong Zhang, Ruohong Du, Lele Zhang, Dongqing Cai, Xiao Sun, Yong Zhou, Jian Zhou, Junchao Qian, Kai Zhong, Kang Zheng, Darnell Kaigler, Wenqing Liu, Xin Zhang, Duohong Zou, Zhengyan Wu

Advanced Functional Materials· Volume 25· Issue 38

Abstract

In this study, a high‐performance T1–T2 dual‐model contrast agent by gadolinium‐doped iron oxide nanoparticle (GION) is developed. Following its development, the application of this agent in vivo by combining doxorubicin (DOX) and folic acid (FA) (FA–GION–DOX) for targeted drug delivery to monitor cancer treatment is explored. GION showed transverse and longitudinal relaxivities up to 182.7 × 10−3 and 7.87 × 10−3m−1 s−1, respectively, upon Gd/Fe ratio in GION at 1/4. DOX released from FA–GION–DOX is pH dependent and only kills cancer cell after FA receptor‐mediated internalization into the acidic environment of endosomes and lysosomes. Systemic delivery of FA–GION–DOX significantly inhibits the growth of tumors and shows good magnetic resonance enhancement in a human cervical cancer xenograft model. Thus, FA–GION–DOX has a potential application for the targeted and magnetic resonance imaging guided therapy of cervical cancer.
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Research context

OpenAlex topics: Nanoparticle-Based Drug Delivery · Lanthanide and Transition Metal Complexes · Iron oxide chemistry and applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Key Laboratory of Ion Beam Bioengineering Hefei Institutes of Physical Science Chinese Academy of Sciences and Anhui Province Hefei 230031 P. R. China

University of Science and Technology of China Hefei 230026 P. R. China

Department of Dental Implant Center Stomatologic Hospital and College Key Laboratory of Oral Diseases Research of Anhui Province Anhui Medical University Hefei 230032 P. R. China

School of Life Sciences Anhui Agricultural University Hefei 230036 P. R. China

High Magnetic Field Laboratory Hefei Institutes of Physical Science Chinese Academy of Sciences Hefei Anhui 230031 P. R. China

Key Laboratory of Materials Physics Institute of Solid State Physics Chinese Academy of Sciences Hefei 230031 P. R. China

Department of Periodontics and Oral Medicine Department of Biomedical Engineering University of Michigan Ann Arbor MI 48109 USA

Funding

National Natural Science Foundation of China · Key Program of Chinese Academy of Sciences · Science and Technology Service Programs of Chinese Academy of Sciences · Anhui Province Funds for Distinguished Young Scientists · President Foundation of Hefei Institutes of Physical Science of Chinese Academy of Sciences

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