DataVXAdvanced Functional MaterialsPaper
journal article·2018-06

Significant Enhancement of Photothermal and Photoacoustic Efficiencies for Semiconducting Polymer Nanoparticles through Simply Molecular Engineering

Tao Dong, Kaikai Wen, Jun Chen, Jin Xie, Weili Fan, Han Ma, Lei Yang, Xiaoxi Wu, Fujian Xu, Aidong Peng, Hui Huang

Advanced Functional Materials· Volume 28· Issue 23
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Source abstract

Abstract

Abstract Semiconducting polymer nanoparticles (SP NPs) are employed as efficient nanoagents for “all‐in‐one” theranostic nanoplatforms with dual photoacoustic imaging (PAI) and photothermal therapy (PTT) functions based on their photothermal conversion effect. However, the mechanisms of tuning the PTT efficiency are still elusive, though several SP NPs with high photothermal efficiency are reported. Herein, two donor–acceptor (D–A) SP NPs PTIGSVS and PIIGSVS with the same donor unit but different acceptor units are designed and synthesized. Through tuning the acceptor unit, PTIGSVS shows more planar backbone structure, stronger D–A strength, redshifted absorption, enhanced extinction efficient, weakened emission properties, and more efficient nonradiative decay in comparison to the polymeric analogue PIIGSVS. Thus, PTIGSVS NPs present much higher photothermal conversion efficiencies (74%) than PIIGSVS NPs (11%), resulting in significantly enhanced in vitro and in vivo PAI and PTT performance. This contribution demonstrates that PTIGSVS NPs are superior PA/PTT agents for effective cancer theranostic and shed light on understanding the relationship between molecular structures and photothermal effect of CPs.
Source: crossref · Quality: baseline

Research context

PolymersNanomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · Photoacoustic and Ultrasonic Imaging · Photodynamic Therapy Research Studies

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

College of Materials Science and Opto‐Electronic Technology and CAS Key Laboratory of Vacuum Physics and CAS Center for Excellence in Topological Quantum Computation University of Chinese Academy of Sciences Beijing 100049 P. R. China

School of Chemistry and Chemical Engineering Jinzhong University Jinzhong 030600 P. R. China

Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety Institute of High Energy Physics Chinese Academy of Sciences Beijing 100049 P. R. China

Key Laboratory of Carbon Fiber and Functional Polymers (Ministry of Education) Beijing Laboratory of Biomedical Materials Beijing Advanced Innovation Center for Soft Matter Sciences and Engineering Beijing University of Chemical Technology Beijing 100029 P. R. China

Department of Dermatology The Third Affiliated Hospital Sun Yat‐sen University No. 600 Tianhe Road Guangzhou Guangdong 510630 P. R. China

Funding

National Natural Science Foundation of China · Natural Science Foundation of Beijing Municipality · Chinese Academy of Sciences

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