DataVXAdvanced Functional MaterialsPaper
journal article·2015-05

Mussel‐Inspired Electrospun Smart Magnetic Nanofibers for Hyperthermic Chemotherapy

Amin GhavamiNejad, Arathyram Ramachandra Kurup Sasikala, Afeesh Rajan Unnithan, Reju George Thomas, Yong Yeon Jeong, Mohammad Vatankhah‐Varnoosfaderani, Florian J. Stadler, Chan Hee Park, Cheol Sang Kim

Advanced Functional Materials· Volume 25· Issue 19
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Source abstract

Abstract

A method for the versatile synthesis of novel, mussel‐inspired, electrospun nanofibers with catechol moieties is reported. These mussel‐inspired nanofibers are used to bind iron oxide nanoparticles (IONPs) and the borate‐containing anticancer drug Bortezomib (BTZ) through a catechol metal binding mechanism adapted from nature. These smart nanofibers exhibit a unique conjugation of Bortezomib to their 1, 2‐benzenediol (catechol) moieties for enabling a pH‐dependent drug delivery towards the cancer cells and the IONPs via strong coordination bonds for exploiting the repeated application of hyperthermia. Thus the synergistic anticancer effect of these mussel‐inspired magnetic nanofibers were tested in vitro for the repeated application of hyperthermia along with the chemotherapy and found that the drug‐bound catecholic magnetic nanofibers exhibited excellent therapeutic efficacy for potential anticancer treatment.
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Research context

Nanomaterials

OpenAlex topics: Electrospun Nanofibers in Biomedical Applications · Nanoparticle-Based Drug Delivery · Dendrimers and Hyperbranched Polymers

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Bionanosystem Engineering Graduate School Chonbuk National University Jeonju 561–756 Republic of Korea

Mechanical Design Engineering Chonbuk National University Jeonju 561–756 Republic of Korea

Department of Radiology Chonnam National University Hwasun Hospital Chonnam National University Medical School Gwangju 501–746 Republic of Korea

Department of Chemistry University of North Carolina Chapel Hill NC 27599–3290 USA

College of Materials Science and Engineering Shenzhen University Shenzhen 518060 PR China

Nanshan District Key Lab for Biopolymers and Safety Evaluation Shenzhen 518060 PR China

Shenzhen Key Laboratory of Special Functional Materials Shenzhen 518060 PR China

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