journal article·2019-02Open access

On the intersection of electrochemistry and mass spectrometry

Lane A. Baker, Gargi S. Jagdale

Abstract

The application of nanopipettes, developed first as a tool for electrochemistry and electrophysiology, as tools for mass spectrometry is considered. Recent examples of advances in electrospray ionization and sampling for mass spectrometry with nanopipettes is discussed. These examples show a scientific intersection that is ripe for further development.
Source: europepmc · Quality: candidate unverified · Source record ↗

Research context

OpenAlex topics: Mass Spectrometry Techniques and Applications · Advanced Chemical Sensor Technologies · Electrochemical Analysis and Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

References (51)

Show source-provided references
1. Electrochemical processes in electrospray ionization mass spectrometry – discussion10.1002/1096-9888(200008)35:8<939::AID-JMS36>3.0.CO;2-V ↗
2. Fenn · 2002
3. Absolute standard hydrogen electrode potential measured by reduction of aqueous nanodrops in the gas phase10.1021/ja073946i ↗
4. Gas-phase electrochemistry: measuring absolute potentials and investigating ion and electron hydration10.1351/PAC-CON-11-08-15 ↗
5. Identification of fleeting electrochemical reaction intermediates using desorption electrospray ionization mass spectrometry10.1021/jacs.5b03862 ↗
6. Observation of electrochemically generated nitrenium ions by desorption electrospray ionization mass spectrometry10.1039/C5SC02939B ↗
7. Two new devices for identifying electrochemical reaction intermediates with desorption electrospray ionization mass spectrometry10.1021/acs.analchem.6b05124 ↗
8. Electrostatic spray ionization from 384-well microtiter plates for mass spectrometry analysis-based enzyme assay and drug metabolism screening10.1021/acs.analchem.7b00536 ↗
9. Ambient in situ analysis and imaging of both hydrophilic and hydrophobic thin layer chromatography plates by electrostatic spray ionization mass spectrometry10.1039/C5RA10977A ↗
10. On-chip spyhole nanoelectrospray ionization mass spectrometry for sensitive biomarker detection in small volumes10.1007/s13361-018-1937-7 ↗
11. Electrochemical push-pull probe: from scanning electrochemical microscopy to multimodal altering of cell microenvironment10.1021/acs.analchem.5b00455 ↗
12. Insights into electrochemical reactions by differential electrochemical mass spectrometry10.1016/j.trac.2015.01.015 ↗
13. Recent advances in real-time and in situ analysis of an electrode-electrolyte interface by mass spectrometry10.1039/C6AN02757A ↗
14. Applications in electrocatalysis, single-cell analysis and high-resolution electrochemical imaging10.1016/j.trac.2016.01.018 ↗
15. Electrochemistry at microscopic liquid-liquid interfaces10.1002/1521-4109(200012)12:18<1433::AID-ELAN1433>3.0.CO;2-2 ↗
16. Applications of nanopipettes in the analytical sciences10.1039/c0an00156b ↗
17. Multifunctional scanning ion conductance microscopy
18. New method for fabrication of fused silica emitters with submicrometer orifices for nanoelectrospray mass spectrometry10.1021/ac201308n ↗
19. Nanoelectrospray emitters: trends and perspective10.1002/mas.20248 ↗
20. Nanoelectrospray – more than just a minimized-flow electrospray ionization source10.1016/S1044-0305(98)00157-3 ↗
21. Shifts in peptide and protein charge state distributions with varying spray tip orifice diameter in nanoelectrospray Fourier transform ion cycitron resonance mass spectrometry10.1021/ac0301402 ↗
22. Joule heating and thermal denaturation of proteins in nano-ESI theta tips10.1007/s13361-017-1732-x ↗
23. Affecting protein charge state distributions in nano-electrospray ionization via in-spray solution mixing using theta capillaries10.1021/ac500721r ↗
24. Electroosmotically driven solution mixing in borosilicate theta glass nESI emitters10.1002/jms.3620 ↗
25. Theta-glass capillaries in electrospray ionization: rapid mixing and short droplet lifetimes10.1021/ac502545r ↗
26. Electrospray ionization from nanopipette emitters with tip diameters of less than 100 nm10.1021/ac402214g ↗
27. Protein-glass surface interactions and ion desalting in electrospray ionization with submicron emitters10.1007/s13361-017-1825-6 ↗
28. Small emitter tips for native mass spectrometry of proteins and protein complexes from nonvolatile buffers that mimic the intracellular environment10.1021/acs.analchem.6b04897 ↗
29. Surface-induced protein unfolding in submicron electrospray emitters10.1021/acs.analchem.6b02499 ↗
30. Ion concentration in micro and nanoscale electrospray emitters10.1007/s00216-018-1043-5 ↗
31. Effect of nanoemitters on suppressing the formation of metal adduct ions in electrospray ionization mass spectrometry10.1021/acs.analchem.6b04218 ↗
32. Electrochemical attosyringe10.1073/pnas.0705102104 ↗
33. Mass spectrometry imaging under ambient conditions10.1002/mas.21360 ↗
34. Ambient desorption/ionization mass spectrometry: evolution from rapid qualitative screening to accurate quantification tool10.1007/s00216-018-1023-9 ↗
35. Ambient mass spectrometry imaging using direct liquid extraction techniques10.1021/acs.analchem.5b04188 ↗
36. Nanopipettes: probes for local sample analysis10.1039/C5SC00668F ↗
37. Local collection, reaction and analysis with theta pipette emitters10.1039/C7AN00109F ↗
38. Segmented flow sampling with push-pull theta pipettes10.1039/C6AN00028B ↗
39. High spatial resolution imaging of mouse pancreatic islets using nanospray desorption electrospray ionization mass spectrometry10.1021/acs.analchem.8b00161 ↗
40. Constant-distance mode nanospray desorption electrospray ionization mass spectrometry imaging of biological samples with complex topography10.1021/acs.analchem.6b03293 ↗
41. Towards high-resolution tissue imaging using nanospray desorption electrospray ionization mass spectrometry coupled to shear force microscopy10.1007/s13361-017-1750-8 ↗
42. Quantitative extraction and mass spectrometry analysis at a single-cell level10.1021/acs.analchem.8b00551 ↗
43. The single-probe: a miniaturized multifunctional device for single cell mass spectrometry analysis10.1021/ac5029038 ↗
44. The single-probe mass spectrometry for single cell analysis and biological tissue imaging10.1055/s-0035-1556152 ↗
45. High resolution tissue imaging using the single-probe mass spectrometry under ambient conditions10.1007/s13361-015-1091-4 ↗
46. Using dicationic ion-pairing compounds to enhance the single cell mass spectrometry analysis using the single-probe: a microscale sampling and ionization device10.1021/acs.analchem.6b01284 ↗
47. Microscale mass spectrometry analysis of extracellular metabolites in live multicellular tumor spheroids10.1021/acs.analchem.7b01746 ↗
48. T-probe: an integrated microscale device for online in situ single cell analysis and metabolic profiling using mass spectrometry10.1021/acs.analchem.8b02927 ↗
49. Metabolomic fingerprints of individual algal cells using the single-probe mass spectrometry technique10.3389/fpls.2018.00571 ↗
50. Universal scaling laws for the disintegration of electrified drops10.1073/pnas.1213708110 ↗
51. The surface charge in electrospraying: its nature and its universal scaling laws10.1016/S0021-8502(98)00780-0 ↗