Rate Acceleration of Light‐Driven Rotary Molecular Motors
Source abstract
Abstract
Abstract One of the key challenges in taking light‐driven unidirectional rotary motors from discovery to application is to increase the rate of rotation. Herein, we review our ongoing efforts to address this issue by meticulous improvement to the molecular design. To accelerate the rotary cycle, we have focused primarily on the rate‐limiting thermal isomerization step. This has been a fascinating and formidable objective, given that the first system we reported had a half‐life of over one week at room temperature! Our research has ultimately led to the construction of a unidirectional rotary molecular motor with a cycle 108 times faster than the original; that is, it can in principle function at 44 rotations per second.
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Research context
OpenAlex topics: Molecular Junctions and Nanostructures · Atomic and Subatomic Physics Research · Photoreceptor and optogenetics research
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (57)
Show source-provided references
1. Molecular Motors(Ed: M. Schliwa) Wiley‐VCH Weinheim Germany2003.
2. R. Berry inMolecular Motors(Ed: M. Schliwa) Wiley‐VCH Weinheim Germany2003 Ch. 4.
3. On myosin see: M. C. Kieke M. A. Titus inMolecular Motors(Ed: M. Schliwa) Wiley‐VCH Weinheim Germany2003 Ch. 1. On kinesin see: N. Hirokawa R. Takemura inMolecular Motors(Ed: M. Schliwa) Wiley‐VCH Weinheim Germany2003 Ch. 3. For dynein see: S. M. King inMolecular Motors(Ed: M. Schliwa) Wiley‐VCH Weinheim Germany2003 Ch. 2.
4. 10.1038/nnano.2006.4510.1038/nnano.2006.45 ↗
5. T. R. Kelly Top. Curr. Chem.2005 262.
6. 10.1071/CH0602510.1071/CH06025 ↗
7. V. Balzani A. Credi M. Venturi Molecular Devices and Machines—A Journey into the Nano World Wiley‐VCH Weinheim Germany2003.10.1002/3527601600 ↗
8. 10.1039/b514487f10.1039/b514487f ↗
9. 10.1021/ar010084w10.1021/ar010084w ↗
10. 10.1021/ar970340y10.1021/ar970340y ↗
11. F. M. Raymo J. F. Stoddart inMolecular Switches(Ed: B. L. Feringa) Wiley‐VCH Weinheim Germany2001 p. 219.10.1002/3527600329.ch7 ↗
12. Molecular Machines and Motors(Eds: J.‐P. Sauvage V. Amendola) Vol. 99 Springer Berlin2001.
13. 10.1021/ar000167x10.1021/ar000167x ↗
14. 10.1038/3502052410.1038/35020524 ↗
15. 10.1038/1643710.1038/16437 ↗
16. 10.1038/415062a10.1038/415062a ↗
17. 10.1021/nl049527q10.1021/nl049527q ↗
18. 10.1021/ja047543j10.1021/ja047543j ↗
19. 10.1021/ja046507h10.1021/ja046507h ↗
20. 10.1002/anie.20046052210.1002/anie.200460522 ↗
21. 10.1002/anie.20050056810.1002/anie.200500568 ↗
22. 10.1039/b607033g10.1039/b607033g ↗
23. 10.1021/ja051088p10.1021/ja051088p ↗
24. 10.1038/nmat145510.1038/nmat1455 ↗
25. 10.1038/440163a10.1038/440163a ↗
26. Whitesides G. M. · Sci. Am. · 2001 · 285 · 70
27. 10.1146/annurev.biophys.33.110502.13271610.1146/annurev.biophys.33.110502.132716 ↗
28. 10.1038/nature0412710.1038/nature04127 ↗
29. 10.1002/anie.20060361810.1002/anie.200603618 ↗
30. 10.1021/jp971763k10.1021/jp971763k ↗
31. 10.1021/ja00061a02910.1021/ja00061a029 ↗
32. 10.1038/4364610.1038/43646 ↗
33. 10.1021/ja052201e10.1021/ja052201e ↗
34. 10.1021/ja970669e10.1021/ja970669e ↗
35. Under conditions where the thermal isomerization is fast relative to the rate of photon absorption the motor will be more efficient. A favourable photoequilibrium simply means that the light energy is used more efficiently.
36. G. Groenhof Ph.D. Thesis University of Groningen2003.
37. 10.1002/cphc.20040052910.1002/cphc.200400529 ↗
38. 10.1021/jo982381t10.1021/jo982381t ↗
39. 10.1021/ja036782o10.1021/ja036782o ↗
40. E. V. Ansyln D. A. Dougherty Modern Physical Organic Chemistry 1st ed. University Science Books Sausalito CA2005.
41. 10.1002/ejoc.20050032210.1002/ejoc.200500322 ↗
42. 10.1002/ejoc.20050032310.1002/ejoc.200500323 ↗
43. Using the X‐ray analysis results of the ketone precursor Harada and co‐workers found the opposite absolute stereochemistry as was assigned in reference [20] using CD spectroscopy.
44. 10.1021/ja002755b10.1021/ja002755b ↗
45. 10.1021/ja012499i10.1021/ja012499i ↗
46. E. L. Eliel S. H. Wilen Stereochemistry of Organic Compounds Wiley New York1994.10.1002/9780470147306 ↗
47. 10.1002/1099-0690(200101)2001:1<15::AID-EJOC15>3.0.CO;2-010.1002/1099-0690(200101)2001:1<15::AID-EJOC15>3.0.CO;2-0 ↗
48. 10.1016/S0040-4039(00)78887-310.1016/S0040-4039(00)78887-3 ↗
49. 10.1039/b208323j10.1039/b208323j ↗
50. 10.1016/S0040-4039(01)94141-310.1016/S0040-4039(01)94141-3 ↗
51. 10.1016/S0040-4039(01)97871-210.1016/S0040-4039(01)97871-2 ↗
52. 10.1021/ja054499e10.1021/ja054499e ↗
53. J. Sandström inTopics in Stereochemistry Vol. 14 (Eds: N. L. Allinger E. L. Eliel S. H. Wilen) Wiley New York1983 p. 160.
54. 10.1039/b402222j10.1039/b402222j ↗
55. 10.1039/b507264f10.1039/b507264f ↗
56. 10.1021/ja058303m10.1021/ja058303m ↗
57. 10.1002/anie.19770429110.1002/anie.197704291 ↗