journal article·2026-02

Ultrasound‐Activated Nanoprobiotic Hydrogel Disrupts the Oral‐Brain Axis to Alleviate Diabetic Periodontitis and Cognitive Decline

Lu Yang, Yazhen Li, Manman Xu, Yongjie Luo, Chengxinyue Ye, Jie zhou, Jun Wang, Xiaoxia Jiang, Xiong Lu, Chaoming Xie

Advanced Functional Materials· Volume 36· Issue 10
Publisher page

Abstract

Abstract Diabetes‐associated periodontitis and cognitive dysfunction form a vicious cycle that impairs tissue repair. Polyphenol‐engineered artificial nanoprobiotics using ultrasound‐responsive dihydrocaffeic acid (DA)‐mediated Fe/Zn bimetallic porphyrin MOFs (Fe‐TCPP‐DA‐Zn), integrated into adaptive hydrogels, is developed. This design enables microenvironment‐responsive antibacterial action through enhanced sonodynamic performance via bandgap reduction, while DA simultaneously restores oral microbiota balance. Zinc ions coordinate dual‐function bone regulation by inhibiting osteoclasts and activating osteoblasts. Single‐cell analysis reveals macrophage‐fibroblast crosstalk as the regeneration driver in diabetic periodontitis. The hydrogel system demonstrates bidirectional therapeutic effects, promoting periodontal soft/hard tissue reconstruction while alleviating anxiety‐like behaviors through oral‐brain axis modulation. The findings propose an antioxidant nanoprobiotic strategy to break the oral‐systemic disease cycle, providing new insights into microbiome‐brain interactions.
Source: crossref · Quality: baseline

Research context

OpenAlex topics: Oral microbiology and periodontitis research · Salivary Gland Disorders and Functions · Dental Health and Care Utilization

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Institute of Biomedical Engineering College of Medicine Southwest Jiaotong University Chengdu Sichuan 610031 China

School of Materials Science and Engineering Southwest Jiaotong University Chengdu Sichuan 610031 China

Department of Orthodontics Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine, College of Stomatology Shanghai Jiao Tong University National Center for Stomatology National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of Stomatology Shanghai Research Institute of Stomatology Shanghai 200125 China

State Key Laboratory of Oral Diseases and National Center for Stomatology and National Clinical Research Center for Oral Diseases West China Hospital of Stomatology Sichuan University Chengdu Sichuan 610041 China

Beijing Institute of Basic Medical Sciences Beijing 100850 China

Funding

National Natural Science Foundation of China · National Key Research and Development Program of China · Fundamental Research Funds for the Central Universities · Natural Science Foundation of Beijing Municipality

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