DataVXAdvanced Functional MaterialsPaper
journal article·2025-12

Hypoxia‐ and pH‐Responsive Metal‐Phenolic Network‐Engineered Ferroptosis‐Immuno Microspheres for Transarterial Chemoembolization in Hepatocellular Carcinoma

Qing Li, Jia Shi, Xiaokang Ruan, Lijie Zhang, Rui Fu, Khemayanto Hidayat, Liqiang Qin, Jiaying Xu, Yu Chong, Chunhong Hu

Advanced Functional Materials· Volume 35· Issue 50
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Source abstract

Abstract

Abstract Drug‐eluting microspheres (DEMs) are extensively utilized in transarterial chemoembolization (TACE) for hepatocellular carcinoma (HCC), but their drug‐loading and release capacities remain suboptimal. Moreover, the hypoxic and immunosuppressive microenvironment induced by embolization hampers treatment efficacy and prognosis. To overcome these challenges, engineered DEMs incorporating a metal‐phenolic network (MPN) is developed, exhibiting dual hypoxia‐ and pH‐responsiveness tailored to the tumor microenvironment. This approach leverages ferroptosis‐immune synergy to improve TACE‐based HCC treatment. The hypoxia‐activated prodrug TH302 is integrated into these modified DEMs, enabling targeted hypoxia‐responsive therapy against residual hypoxic tumor cells post‐embolization. The MPN, composed of tannic acid (TA), Fe 3+ , and Mn 2+ , improves TH302 loading efficiency and ensures controlled pH‐responsive drug release. Additionally, the MPN reverses immunosuppression within the tumor microenvironment, triggering a ferroptosis‐immune cascade. This approach not only demonstrates efficacy in treating embolized tumors but, when combined with a PD‐L1 inhibitor, reduces distant non‐embolized liver tumors. This integrated approach represents a significant advancement in TACE, improving therapeutic efficacy and clinical outcomes in the management of HCC.
Source: crossref · Quality: baseline

Research context

OpenAlex topics: Ferroptosis and cancer prognosis · Immune cells in cancer · Nanoplatforms for cancer theranostics

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Radiology The First Affiliated Hospital of Soochow University Institute of Medical Imaging Soochow University No. 899 Pinghai Road Suzhou Jiangsu 215000 China

State Key Laboratory of Radiation Medicine and Protection School of Radiation Medicine and Protection & School for Radiological and Interdisciplinary Sciences (RAD‐X) Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions Suzhou Medical College Soochow University 199 Renai Road Suzhou Jiangsu 215123 China

Department of Gastroenterology People's Hospital of Dongxihu District Wuhan Hubei 430040 China

Department of Radiology Union Hospital Tongji Medical College Huazhong University of Science and Technology Jiefang Avenue 1277 Hubei Provincial Clinical Research Center for Precision Radiology & Interventional Medicine Hubei Key Laboratory of Molecular Imaging Wuhan Hubei 430022 China

Department of Nutrition and Food Hygiene School of Public Health Soochow University 199 Renai Road Suzhou Jiangsu 215123 China

Funding

National Natural Science Foundation of China · Natural Science Foundation of Jiangsu Province

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