journal article·2025-09

Ear‐Area Soft Electronics for Advanced Healthcare Monitoring

Yue Yu, Haoyu Zhang, Xiaosen Pan, Ming Yuan, Yuyang Sun, Peng Han, Fang Quan, Baiya Li, Feng Xu, Yunsheng Fang

Advanced Functional Materials· Volume 35· Issue 38
Publisher page

Abstract

Abstract The ear harbors a wealth of critical physiological and pathological information, positioning it as an ideal site for healthcare monitoring. However, the intricate geometry and physiological sensitivity of the ear pose formidable technical hurdles to effective healthcare monitoring. Soft electronics, renowned for their mechanical deformability, excellent skin conformability, and biocompatibility, offer compelling advantages, particularly within the emerging contexts of fifth‐generation technology and the Internet of Things. These innovations provide essential technical support for achieving comprehensive healthcare monitoring via ear‐area soft electronics. This review comprehensively outlines the recent advancements in ear‐area soft electronics for advanced healthcare monitoring. The authors begin by elucidating the physiological properties of the external, middle, and inner ear from clinical perspectives. Subsequently, leveraging these anatomical insights, the state‐of‐the‐art ear‐area soft bioelectric, biophysical, biochemical, and multimodal electronics for healthcare monitoring are explored. Furthermore, insights are offered into the enduring challenges and prospective directions for ear‐area soft electronics from systematic sensor design, data processing methodologies, and translational applications. As a whole, ear‐area soft electronics will provide new paradigms shift in the evolution of wearable and implantable electronics, thereby fostering the rapid and high‐quality development of healthcare monitoring systems.
Source: crossref · Quality: baseline

Research context

OpenAlex topics: Wireless Body Area Networks · ECG Monitoring and Analysis · Non-Invasive Vital Sign Monitoring

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Bioinspired Engineering & Biomechanics Center (BEBC) The Key Laboratory of Biomedical Information Engineering of Ministry of Education School of Life Science and Technology Xi'an Jiaotong University Xi'an 710049 P.R. China

Department of Otolaryngology Head and Neck Surgery The First Affiliated Hospital of Xi'an Jiaotong University Xi'an 710061 P.R. China

Funding

National Natural Science Foundation of China

References (100+)

Show source-provided references
1. 10.1038/s41591-022-02171-w10.1038/s41591-022-02171-w ↗
2. Naidoo R. · Nature · 583 · 19810.1038/d41586-020-01999-x ↗
3. 10.1021/acsnano.2c1260610.1021/acsnano.2c12606 ↗
4. 10.1016/j.arr.2020.10117410.1016/j.arr.2020.101174 ↗
5. 10.1016/S0140-6736(21)00568-710.1016/S0140-6736(21)00568-7 ↗
6. 10.1002/adfm.20220480310.1002/adfm.202204803 ↗
7. 10.1126/sciadv.abg918010.1126/sciadv.abg9180 ↗
8. 10.1038/s41551-022-00916-z10.1038/s41551-022-00916-z ↗
9. 10.1038/s41570-022-00439-w10.1038/s41570-022-00439-w ↗
10. 10.1038/s41591-021-01381-y10.1038/s41591-021-01381-y ↗
11. 10.1016/S0140-6736(20)32228-510.1016/S0140-6736(20)32228-5 ↗
12. 10.1016/S2214-109X(21)00081-410.1016/S2214-109X(21)00081-4 ↗
13. 10.1021/acs.chemrev.1c0050210.1021/acs.chemrev.1c00502 ↗
14. 10.1021/acs.chemrev.3c0050210.1021/acs.chemrev.3c00502 ↗
15. 10.1021/acs.chemrev.1c0050210.1021/acs.chemrev.1c00502 ↗
16. 10.1002/VIW.2022005010.1002/VIW.20220050 ↗
17. 10.1021/acs.chemrev.4c0027110.1021/acs.chemrev.4c00271 ↗
18. 10.1002/adma.20210417810.1002/adma.202104178 ↗
19. 10.1002/smll.20200045010.1002/smll.202000450 ↗
20. 10.1038/s41551-021-00685-110.1038/s41551-021-00685-1 ↗
21. 10.1016/j.biomaterials.2022.12143510.1016/j.biomaterials.2022.121435 ↗
22. 10.1002/smll.20220787910.1002/smll.202207879 ↗
23. 10.1021/acs.chemrev.3c0042510.1021/acs.chemrev.3c00425 ↗
24. 10.1038/s44222-024-00175-410.1038/s44222-024-00175-4 ↗
25. 10.1021/acsnano.2c1260610.1021/acsnano.2c12606 ↗
26. 10.1002/adma.20220025210.1002/adma.202200252 ↗
27. 10.1016/j.matt.2021.03.00510.1016/j.matt.2021.03.005 ↗
28. 10.1016/j.mattod.2024.03.00510.1016/j.mattod.2024.03.005 ↗
29. 10.1038/s41467-023-39814-610.1038/s41467-023-39814-6 ↗
30. 10.1038/s41551-023-01095-110.1038/s41551-023-01095-1 ↗
31. 10.1016/j.matt.2022.11.02310.1016/j.matt.2022.11.023 ↗
32. 10.1002/smll.20210696010.1002/smll.202106960 ↗
33. 10.1038/s41467-024-47408-z10.1038/s41467-024-47408-z ↗
34. 10.2471/BLT.21.28564310.2471/BLT.21.285643 ↗
35. 10.1021/acssensors.7b0024710.1021/acssensors.7b00247 ↗
36. 10.1109/TBME.2022.314568810.1109/TBME.2022.3145688 ↗
37. 10.1109/MPRV.2021.312117110.1109/MPRV.2021.3121171 ↗
38. 10.1038/s41467-024-48682-710.1038/s41467-024-48682-7 ↗
39. 10.1016/j.biosx.2022.10015310.1016/j.biosx.2022.100153 ↗
40. 10.1109/JIOT.2022.314440010.1109/JIOT.2022.3144400 ↗
41. 10.1016/j.nanoen.2023.10890010.1016/j.nanoen.2023.108900 ↗
42. 10.1007/s44258-023-00001-310.1007/s44258-023-00001-3 ↗
43. 10.1002/adma.20170264810.1002/adma.201702648 ↗
44. 10.1021/acs.chemrev.3c0050710.1021/acs.chemrev.3c00507 ↗
45. 10.1021/acs.chemrev.3c0082310.1021/acs.chemrev.3c00823 ↗
46. 10.1021/acs.chemrev.3c0037410.1021/acs.chemrev.3c00374 ↗
47. 10.1021/acs.chemrev.3c0038010.1021/acs.chemrev.3c00380 ↗
48. 10.1002/aenm.20200383510.1002/aenm.202003835 ↗
49. 10.1038/s41467-018-04937-810.1038/s41467-018-04937-8 ↗
50. Dai N. · Innovation · 2025 · 6
51. 10.1038/s41746-023-00835-610.1038/s41746-023-00835-6 ↗
52. 10.1088/1741-2552/ac63eb10.1088/1741-2552/ac63eb ↗
53. 10.1016/j.compmedimag.2021.10199010.1016/j.compmedimag.2021.101990 ↗
54. 10.1038/s41467-023-39850-210.1038/s41467-023-39850-2 ↗
55. 10.1038/s41928-022-00723-z10.1038/s41928-022-00723-z ↗
56. 10.1038/s41598-017-06925-210.1038/s41598-017-06925-2 ↗
57. 10.1109/JSAC.2020.304242110.1109/JSAC.2020.3042421 ↗
58. 10.1016/j.jnca.2020.10287310.1016/j.jnca.2020.102873 ↗
59. 10.1016/j.jnca.2021.10316410.1016/j.jnca.2021.103164 ↗
60. 10.1038/s41746-020-00324-010.1038/s41746-020-00324-0 ↗
61. 10.1016/j.ebiom.2018.01.01110.1016/j.ebiom.2018.01.011 ↗
62. 10.1016/j.bjps.2020.03.02510.1016/j.bjps.2020.03.025 ↗
63. 10.1007/BF0354643510.1007/BF03546435 ↗
64. 10.1109/TIE.2013.224265610.1109/TIE.2013.2242656 ↗
65. 10.1088/0967-3334/35/2/11110.1088/0967-3334/35/2/111 ↗
66. 10.1109/JTEHM.2013.227787010.1109/JTEHM.2013.2277870 ↗
67. 10.1016/S0925-4005(01)00612-810.1016/S0925-4005(01)00612-8 ↗
68. 10.1016/j.bjps.2008.01.04610.1016/j.bjps.2008.01.046 ↗
69. 10.1088/1741-2552/acfcda10.1088/1741-2552/acfcda ↗
70. 10.1109/JTEHM.2017.270255810.1109/JTEHM.2017.2702558 ↗
71. 10.1007/s10096-011-1185-210.1007/s10096-011-1185-2 ↗
72. 10.1016/j.ajps.2022.04.00310.1016/j.ajps.2022.04.003 ↗
73. 10.3390/bios1108024510.3390/bios11080245 ↗
74. 10.1039/D1CS00003A10.1039/D1CS00003A ↗
75. 10.1016/j.heares.2014.12.00310.1016/j.heares.2014.12.003 ↗
76. Murphy R. · J. Otolaryngol. Head Neck Surg. · 2012 · 41 · S75
77. 10.3389/felec.2021.68551310.3389/felec.2021.685513 ↗
78. 10.1098/rstb.2015.048310.1098/rstb.2015.0483 ↗
79. 10.1113/JP27918910.1113/JP279189 ↗
80. 10.3390/audiolres1303003510.3390/audiolres13030035 ↗
81. 10.3389/fphar.2020.59609910.3389/fphar.2020.596099 ↗
82. 10.1016/j.prosdent.2021.01.02610.1016/j.prosdent.2021.01.026 ↗
83. 10.1016/j.heares.2019.10788110.1016/j.heares.2019.107881 ↗
84. 10.1016/j.mattod.2023.12.00310.1016/j.mattod.2023.12.003 ↗
85. Seonghyeon N. · Soft Sci. · 2023 · 3 · 28
86. Kim K. H. · Soft Sci. · 2024 · 4 · 24
87. 10.2196/4880310.2196/48803 ↗
88. 10.1080/17434440.2021.201432110.1080/17434440.2021.2014321 ↗
89. 10.1038/s41598-019-53115-310.1038/s41598-019-53115-3 ↗
90. 10.1109/TBME.2019.291142310.1109/TBME.2019.2911423 ↗
91. 10.1088/1741-2552/ad33af10.1088/1741-2552/ad33af ↗
92. 10.1126/sciadv.adg967110.1126/sciadv.adg9671 ↗
93. 10.1038/srep1674310.1038/srep16743 ↗
94. 10.3390/brainsci1006032110.3390/brainsci10060321 ↗
95. 10.1109/TBME.2015.245906110.1109/TBME.2015.2459061 ↗
96. 10.1098/rsos.22162010.1098/rsos.221620 ↗
97. 10.1109/LSENS.2022.319827910.1109/LSENS.2022.3198279 ↗
98. 10.1016/j.snb.2015.07.11110.1016/j.snb.2015.07.111 ↗
99. 10.1109/TBCAS.2023.327264910.1109/TBCAS.2023.3272649 ↗
100. 10.1007/s00405-010-1408-710.1007/s00405-010-1408-7 ↗