journal article·2026-01Open access

Dual‐Responsive Fluorescent Probes: Advances in Biosensing, Diagnosis and Therapy

Jihong Liu, Luling Wu, Zhirong Zhu, Chenxu Yan, Yutao Zhang, Ting Yang, Shiyun Xu, Haojian Yang, Shichang Liu, Wenjun Tang, Xiaoyu Ma, Simon E. Lewis, Qi Wang, Tony D. James, Wei‐Hong Zhu

Advanced Functional Materials· Volume 36· Issue 5

Abstract

Abstract Recent years have witnessed rapid developments in molecular imaging for fundamental biomedical research and clinical diagnostics. Particularly, fluorescence imaging represents an indispensable technique, enabling longitudinal monitoring of intravital physiopathological activities in a real‐time and non‐invasive manner. Dual‐responsive fluorescent probes, which circumvent non‐specific signal activation and background noise, have exhibited remarkably enhanced selectivity, high spatiotemporal resolution, and multiplexing capability. With the increasing prevalence of precision medicine, dual‐responsive fluorescent probes offer promising opportunities to enhance diagnostic accuracy and optimize therapeutic efficacy. In this review, the design strategies for customized dual‐responsive fluorescent probes are comprehensively summarized. Subsequently, representative examples in biosensing, diagnosis, and therapy are highlighted. Finally, the review provides perspectives and discusses key challenges in advancing dual‐responsive fluorescent probes toward clinical biomedical applications.
Source: crossref · Quality: baseline

Research context

OpenAlex topics: Nanoplatforms for cancer theranostics · Luminescence and Fluorescent Materials · Molecular Sensors and Ion Detection

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering Shanghai Key Laboratory of Functional Materials Chemistry Feringa Nobel Prize Scientist Joint Research Center Institute of Fine Chemicals Frontiers Science Center for Materiobiology and Dynamic Chemistry School of Chemistry and Molecular Engineering East China University of Science and Technology Shanghai 200237 P. R. China

Department of Chemistry University of Bath Bath BA2 7AY UK

Center of Photosensitive Chemicals Engineering East China University of Science and Technology Shanghai 200237 P. R. China

School of Chemistry and Chemical Engineering Henan Normal University Xinxiang 453007 P. R. China

Funding

National Key Research and Development Program of China · National Natural Science Foundation of China · Science and Technology Commission of Shanghai Municipality · China Postdoctoral Science Foundation

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