DataVXAdvanced Functional MaterialsPaper
journal article·2025-11Open access

Precise Diffusion of Gaseous H 2 S “Bomb” Potentiates NIR‐II Imaging‐Guided Photothermal Therapy by Relieving Heat Tolerance and Disturbing Cellular Homeostasis for Synergistic Orthotopic Glioblastoma Treatment

Donghua Zou, Fangzhou Guo, Qiulan Jiang, Guining Liang, Zixiang Meng, Zhaoshi Bao, Xiuxin Lu, Mika Pan, Chun Zou, Jieqiong Xie, Guoyuan Ling, Tianfu Zhang, Ping Shangguan, Shipeng Ning, Ben Zhong Tang

Advanced Functional Materials· Volume 35· Issue 46
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Source abstract

Abstract

Abstract Although photothermal therapy (PTT) has thrived as a novel cancer treatment method with the merits of high spatiotemporal specificity and minimal invasion, the limited penetration depth and poor blood−brain barrier permeability pose significant challenges in glioblastoma (GBM) treatment. Here, a near‐infrared‐II (NIR‐II) emissive nanosystem based on aggregation‐induced emission photothermal agents and H 2 S prodrug for brain‐targeted orthotopic GBM synergistic therapy is innovatively developed. It achieves through‐skull tumor visualization by NIR‐II/photothermal imaging, assisting in real‐time monitoring of GBM in the brain area. Moreover, the in situ released H 2 S triggered by photothermal stimulation efficiently infiltrates deep tumors and evokes mitochondrial dysfunction and cellular apoptosis. The gas therapy can also deplete ATP and subsequently downregulate HSP90 expression, thus inhibiting the heat tolerance of lethal tumors and enhancing PTT for GBM. Incorporating non invasive H 2 S gas “bomb” in GBM therapy may drive the clinical application of PTT, reducing the risk of incomplete tumor cell eradication due to intrinsic resistance to thermal.
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Research context

Nanomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · thermodynamics and calorimetric analyses · Thermal Regulation in Medicine

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Neurology The Second Affiliated Hospital of Guangxi Medical University Nanning Guangxi 530007 China

Department of Neurosurgery Guangxi Medical University Cancer Hospital Nanning Guangxi 530021 China

Department of Radiation Oncology The Affiliated Hospital of Youjiang Medical University for Nationalities Baise Guangxi 533000 China

Key Laboratory of Research on Clinical Molecular Diagnosis for High Incidence Diseases in Western Guangxi Guangxi Higher Education Institutions Baise Guangxi 533000 China

Guangzhou Institute of Cancer Research The Affiliated Cancer Hospital School of Biomedical Engineering Guangzhou Medical University Guangzhou Guangdong 511436 China

Department of Neurosurgery Beijing Tiantan Hospital Capital Medical University Beijing 100054 China

Research Center of Nanomedicine Technology The Second Affiliated Hospital of Guangxi Medical University Nanning Guangxi 530007 China

Guangdong Basic Research Center of Excellence for Aggregate Science School of Science and Engineering Shenzhen Institute of Aggregate Science and Technology The Chinese University of Hong Kong Shenzhen (CUHK‐Shenzhen) Guangdong 518172 China

Funding

National Natural Science Foundation of China · National Key Research and Development Program of China · Science, Technology and Innovation Commission of Shenzhen Municipality

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