Wirefree electroceuticals: 3D electrical and electrochemical stimulation of biological systems
Source abstract
Abstract
There is an increasing recognition that biological systems can be influenced in many ways by electron and ion transfer reactions, potentials and electric fields that can be generated in electrochemical experiments. This short review considers recent investigations to interface electrochemistry with living systems using a wirefree, bipolar or wireless strategy. The focus is on biocompatible, electronically conducting polymers whose 2D and 3D structure is optimised for their use in wirefree electrochemical systems and the important emerging role of 3D structured films as well as 3D bipolar and feeder electrodes. Finally, we consider some remaining challenges and prospects for the field in the area of electroceuticals.
Source: expertdata · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Conducting polymers and applications · Electrochemical Analysis and Applications · Electrochemical sensors and biosensors
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (100+)
Show source-provided references
1. Junctional intercellular communication: the cell-to-cell membrane channel10.1152/physrev.1981.61.4.829 ↗
2. The interplay between genetic and bioelectrical signaling permits a spatial regionalisation of membrane potentials in model multicellular ensembles10.1038/srep35201 ↗
3. In-vivo electrochemistry: what can we learn about living systems?10.1021/cr068082i ↗
4. Matsue · Chem electrochem · 2019 · 6 · 5354
5. Neuronal activity in ontogeny and oncology10.1016/j.trecan.2016.12.008 ↗
6. In Vitro electrochemistry of biological systems10.1146/annurev.anchem.1.031207.113038 ↗
7. Payne · 2019 · vol. 1 · 114
8. Synaptic proximity enables NMDAR signalling to promote brain metastasis10.1038/s41586-019-1576-6 ↗
9. EMT in cancer10.1038/nrc.2017.118 ↗
10. Electrochemically stimulating developments in bioelectronic medicine Bioelectron
11. A jump-start for electroceuticals10.1038/496159a ↗
12. Building a bioelectronic medicine movement 2019: insights from leaders in industry, academia10.1186/s42234-020-0037-8 ↗
13. Electroactive biomaterials and systems for cell fate determination and tissue regeneration: design and applications10.1002/adma.202007429 ↗
14. Hays Enhancing plasticity in central networks improves motor and sensory recovery after nerve damage10.1038/s41467-019-13695-0 ↗
15. Implant boosts activity in injured brain10.1038/448522a ↗
16. Technology of deep brain stimulation: current status and future directions10.1038/s41582-020-00426-z ↗
17. Electrical stimulation as a novel tool for regulating cell behavior in tissue engineering Biomater
18. Molecular mechanisms underlying antiproliferative and differentiating responses of hepatocarcinoma cells to subthermal electric stimulation10.1371/journal.pone.0084636 ↗
19. Skeletal muscle cell proliferation and differentiation on polypyrrole substrates doped with extracellular matrix components10.1016/j.biomaterials.2009.06.059 ↗
20. Spatiotemporal neuromodulation therapies engaging muscle synergies improve motor control after spinal cord injury10.1038/nm.4025 ↗
21. Electrical stimulation pain proced
22. Electrical stimulation promotes nerve cell differentiation on polypyrrole/poly (2-methoxy-5 aniline sulfonic acid) composites10.1088/1741-2560/6/6/065002 ↗
23. Ketoconazole resistant Candida albicans is sensitive to a wireless electroceutical wound care10.1016/j.bioelechem.2021.107921 ↗
24. Electroceutical fabric lowers zeta potential and eradicates coronavirus infectivity upon contact10.1038/s41598-021-00910-6 ↗
25. Deep brain stimulation: current challenges and future directions10.1038/s41582-018-0128-2 ↗
26. Wireless electronic light emission: an introduction to bipolar electrochemistry10.1021/acs.jchemed.2c00573 ↗
27. Bipolar electrochemistry: from materials science to motion and beyond10.1021/ar400039k ↗
28. Enriching cations using electric field gradients generated by bipolar electrodes in the absence of buffer
29. Principles of Bipolar Electrochemistry
30. Closed bipolar electrode array for optical reporting reaction-coupled electrochemical sensing and imaging
31. A compelling case for bipolar electrochemistry
32. Bipolar electrochemistry10.1002/anie.201300947 ↗
33. Bipolar electrochemistry—a wireless approach for electrode reactions10.1016/j.coelec.2017.02.001 ↗
34. Bipolar electrochemistry, a focal point of future research10.1080/00986445.2016.1147031 ↗
35. Bipolar electrochemistry: a powerful tool for electrifying functional material synthesis10.1021/acs.accounts.9b00337 ↗
36. Rational design of electrochemiluminescent devices10.1021/acs.accounts.1c00230 ↗
37. Increasing electrochemiluminescence intensity of a wireless electrode array chip by thousands of times using a diode for sensitive visual detection by a digital camera10.1021/acs.analchem.5b04304 ↗
38. A portable wireless single-electrode system for electrochemiluminescent analysis Electrochim
39. Electrochemical communication between living cells and conductive surfaces10.1016/j.coelec.2017.09.013 ↗
40. Progress in conducting polymers for biointerfacing and biorecognition applications
41. Green · 2008 · vol. 29 · 3393
42. Wireless on-demand drug delivery10.1038/s41928-021-00614-9 ↗
43. Wireless dual stimuli actuation of dye sensitized conducting polymer hybrids10.1002/adfm.202101171 ↗
44. Recent advances in bipolar electrochemistry with conducting polymers
45. Prospective on doping engineering of conductive polymers for enhanced interfacial properties Appl
46. Applications of conducting polymer composites to electrochemical sensors: a review10.1016/j.apmt.2017.09.001 ↗
47. Noninvasive control of bacterial biofilms by wireless electrostimulation10.1021/acsbiomaterials.9b01199 ↗
48. Cell attachment functionality of bioactive conducting polymers for neural interfaces10.1016/j.biomaterials.2009.03.043 ↗
49. Gelatin composites mediate brain endothelial cell adhesion10.1039/c3tb20374c ↗
50. A. Varghese Conducting Polymers: A Versatile Material for Biomedical Applications
51. In situ polymerization of conducting polymers around living neural cells: cellular effect study10.1016/j.colsurfb.2022.112410 ↗
52. Biocompatible conductive hydrogels: applications in the field of biomedicine10.3390/ijms23094578 ↗
53. Conductive polymers and composites-based systems: an incipient stride in drug delivery and therapeutics realm10.1016/j.jconrel.2023.02.017 ↗
54. A review on the direct electroplating of polymeric materials10.1007/s10853-021-06246-w ↗
55. Hydrogel-mediated direct patterning of conducting polymer films with multiple surface chemistries10.1002/adma.201306093 ↗
56. Conducting polymers: a comprehensive review on recent advances in synthesis, properties and applications10.1039/D0RA07800J ↗
57. Conductive polymers: towards a smart biomaterial for tissue engineering10.1016/j.actbio.2014.02.015 ↗
58. Conducting polymers for tissue engineering10.1021/acs.biomac.8b00276 ↗
59. Bipolar electrochemical stimulation using conducting polymers for wireless electroceuticals and future directions10.1021/acsabm.2c00679 ↗
60. Wireless electrochemical actuation of conducting polymers
61. Electropolymerization on wireless electrodes towards conducting polymer microfibre networks10.1038/ncomms10404 ↗
62. Regenerable bipolar electrochemiluminescence device using glassy carbon bipolar electrode, stainless steel driving electrode and cold patch10.1016/j.electacta.2017.12.186 ↗
63. Effect of placement angles on wireless electrocoagulation for bipolar aluminum electrodes
64. Effects of size and position of an unconnected aluminum electrode on bipolar anodization in an AC electric field10.1038/s41598-021-01633-4 ↗
65. Two-step bipolar anodization: design of titanium with two different faces10.1016/j.elecom.2022.107376 ↗
66. Development of a wireless feeding system for highly effective electro-photocatalytic degradation of organic pollutants from aqueous solutions Electrochim
67. Modification of glassy carbon with polypyrrole through an aminophenyl linker to create supercapacitive materials using bipolar electrochemistry Electrochem
68. One-step preparation of bifunctionalized surfaces by bipolar electrografting10.1039/C5RA20156J ↗
69. Novel platinum bipolar electrode for irreversible electroporation in prostate cancer: preclinical study in the beagle prostate10.1038/s41598-021-96734-5 ↗
70. Bipolar electrochemiluminescence imaging: a way to investigate the passivation of silicon surfaces10.1002/cphc.202100112 ↗
71. Wireless imaging of transient redox activity based on bipolar light-emitting electrode arrays10.1021/acs.analchem.2c02872 ↗
72. A large-scale, wireless electrochemical bipolar electrode microarray10.1021/ja902683f ↗
73. Wireless electrochemical DNA microarray sensor10.1021/ja802013q ↗
74. Advances in bipolar electrochemiluminescence for the detection of biorelevant molecular targets10.1016/j.coelec.2019.04.004 ↗
75. Pressure-driven bipolar electrochemistry10.1021/ja111050h ↗
76. Wireless electromechanical enantio-responsive valves10.1002/chir.23521 ↗
77. Spatially controlled, bipolar, cortical stimulation with high-capacitance, mechanically flexible subdural surface microelectrode arrays10.1126/sciadv.abq6354 ↗
78. Electric field-induced chemical locomotion of conducting objects10.1038/ncomms1550 ↗
79. True bulk synthesis of Janus objects by bipolar electrochemistry10.1002/adma.201201623 ↗
80. Capillary-assisted bipolar electrochemistry: a focused mini review
81. Neural responses to electrical stimulation in 2D and 3D in vitro environments10.1016/j.brainresbull.2019.07.016 ↗
82. Electrochemiluminescence at 3D printed titanium electrodes10.3389/fchem.2021.662810 ↗
83. Wireless electrochemiluminescence at functionalised gold microparticles using 3D titanium electrode arrays10.1039/D1CC01010G ↗
84. Effect of cavity architecture on the surface-enhanced emission from site-selective nanostructured cavity arrays10.1021/jp210343t ↗
85. Tunable metallic nanostructures using 3D printed nanosphere templates Electrochem
86. Fabrication and optical properties of periodic Ag nano-pore and nano-particle arrays with controlled shape and size over macroscopic length scales10.1002/adem.201700532 ↗
87. Enhanced electrochemiluminescence from 3D nanocavity electrode arrays
88. Wireless electrochemical light emission in ultrathin 2D nanoconfinements10.1039/D2SC04670A ↗
89. Wireless enhanced electrochemiluminescence at a bipolar microelectrode in a solid-state micropore10.1149/1945-7111/abbbc1 ↗
90. Intracellular wireless analysis of single cells by bipolar electrochemiluminescence confined in a nanopipette10.1002/ange.202002323 ↗
91. Impedimetric characterization of bipolar nanoelectrodes with cancer cells10.1021/acsomega.1c03547 ↗
92. Visual color-switch electrochemiluminescence biosensing of cancer cell based on multichannel bipolar electrode chip10.1021/acs.analchem.5b04716 ↗
93. Immuno-Electrochemiluminescent imaging of a single cell based on functional nanoprobes of heterogeneous Ru(bpy)32+@SiO2/Au nanoparticles10.1021/acs.analchem.8b02141 ↗
94. High-throughput selective capture of single circulating tumor cells by dielectrophoresis at a wireless electrode array10.1021/jacs.7b03288 ↗
95. Wireless nanobioelectronics for electrical intracellular sensing10.1021/acsanm.9b01374 ↗
96. Remotely controlled in situ growth of silver microwires forming bioelectronic interfaces10.1021/acsami.8b22075 ↗
97. Bipolar electroactive conducting polymers for wireless cell stimulation10.1016/j.apmt.2020.100804 ↗
98. Direct electrochemistry of redox enzymes as a tool for mechanistic studies10.1021/cr0680742 ↗
99. Nanomaterials for bio-functionalized electrodes: recent trends10.1039/c3tb20881h ↗
100. Cytochrome c in cancer therapy and prognosis Biosci