DataVXAdvanced Functional MaterialsPaper
journal article·2025-01

Fast Recoverable Shape Memory Cryogels Engineered with Surfactant‐Stabilized Bubbles and Vermiculite for Non‐Compressible Hemostasis

Binhui Wang, Bin Zhu, Yihao Liu, Bowen Ren, Yurong Chen, Luyao Feng, Sergio Martin‐Saldana, Bochen An, Yining Gong, Yiming Ren, Jinqing Li, Da Huang, Baoji Du, Jianheng Liu, Yazhong Bu

Advanced Functional Materials· Volume 35· Issue 4
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Source abstract

Abstract

Abstract Shape memory cryogels hold immense promise for non‐compressible hemostasis due to their shape recovery after contacting with blood. However, there is still a lack of an easy way to accelerate the shape‐recovery speed which is highly associated with its performance. Meanwhile, the incorporation of extra pro‐coagulation mechanisms will further improve the hemostatic efficacy. Herein, surfactant‐stabilized bubbles are used to improve the shape‐recovery speed of cryogels (GHP) through the modulation of porosity and pore size based on the capillary action. Additionally, 2D nanosheet vermiculite (VMT) is fabricated and incorporated into the system to get VMT@GHP cryogels. Remarkably, VMT@GHP exhibits a fast shape recovery speed (1.3 ± 0.3 s in the blood) among reported hemostats and the ability to promote blood coagulation. Animal studies show that VMT@GHP significantly accelerates the hemostasis in both rat and pig models, even in heparinized situations. In summary, VMT@GHP represents a highly effective solution for non‐compressible hemorrhage control, with promising prospects for clinical translation.
Source: crossref · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Hemostasis and retained surgical items · Hydrogels: synthesis, properties, applications · Bone Tissue Engineering Materials

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

College of Biological Science and Engineering Fuzhou University Fuzhou Fujian 350108 China

Department of Burn/Plastic Surgery and Wound Repair the Second Affiliated Hospital of Xi'an Jiaotong University Xi'an Shaanxi 710061 China

Institute of Medical Engineering Department of Biophysics School of Basic Medical Sciences Health Science Center Xi'an Jiaotong University Xi'an 710061 China

Department of Orthopedics The Fourth Medical Centre of Chinese PLA General Hospital Beijing 100089 China

Medical School of Chinese PLA Beijing 100853 China

POLYMAT Applied Chemistry Department Faculty of Chemistry University of the Basque Country UPV/EHU Paseo Manuel de Lardizabal 3 Donostia‐San Sebastián 20018 Spain

Department of Spine Surgery Honghui Hospital Xi'an Jiaotong University Xi'an 710054 China

Funding

National Natural Science Foundation of China

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