DataVXAdvanced Functional MaterialsPaper
journal article·2025-03Open access

Mitochondria‐Targeted Photoredox Catalysis Activates Pyroptosis for Effective Tumor Therapy

Bin Zhao, Jingyi Ye, Zeyu Chen, Danyang Chen, Jiahui Chai, Zhongxu Luo, Xu Chen, Dan Shao, Qianjun He, Chunhai Fan, Huan Zhang, Honglu Zhang

Advanced Functional Materials· Volume 35· Issue 12
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Source abstract

Abstract

Abstract The development of biocompatible and efficient photocatalytic redox systems to mimic bio‐photoreactors in living cells holds great potential for manipulating intracellular biochemical reaction processes and thus advancing tumor therapy. In this study, a mitochondria‐targeted photoredox catalyst, 2D vacancy‐rich molybdenum oxide nanosheets (Mt‐VR‐MoO 3 ) is presented. These nanosheets possess a high density of oxygen vacancies (19.2%) and exhibit strong photocatalytic redox activity under near‐infrared (NIR) light. Following a two‐step functionalization, Mt‐VR‐MoO 3 effectively disrupts mitochondrial electron flow in an oxygen‐independent manner upon irradiation with second near‐infrared (NIR‐II) light. This targeted disruption leads to on‐demand induction of substantial damage to tumor cell mitochondria, characterized by increased production of mitochondrial reactive oxygen species (mtROS) and the release of cytochrome c (Cyt c ), which collectively trigger the pyroptosis of cancer cells. The approach achieved tumor‐targeted photocatalytic eradication with high efficacy (tumor growth inhibition rate of 86.9%) in an orthotopic breast 4T1 murine tumor model, with no observable harm to normal organs. These findings provide inspiration for manipulating intracellular biochemical reactions using artificial photocatalytic materials, paving the way for pyroptosis activation as a promising approach in tumor therapy.
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Research context

NanomaterialsBiomaterialsCatalysis & surfaces

OpenAlex topics: Inflammasome and immune disorders · Heme Oxygenase-1 and Carbon Monoxide · Mitochondrial Function and Pathology

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

School of Biomedical Sciences and Engineering South China University of Technology Guangzhou International Campus Guangzhou 511442 China

School of Sensing Science and Engineering School of Electronic Information and Electrical Engineering Shanghai Jiao Tong University Shanghai 200240 China

National Engineering Research Center for Tissue Restoration and Reconstruction South China University of Technology Guangzhou 510006 China

School of Agriculture and Biology Shanghai Jiao Tong University Shanghai 200240 China

Shanghai Key Laboratory of Hydrogen Science & Center of Hydrogen Science School of Materials Science and Engineering Shanghai Jiao Tong University Shanghai 200240 China

School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative Molecules National Center for Translational Medicine Shanghai Jiao Tong University Shanghai 200240 China

Shanghai Key Laboratory for Nucleic Acids Chemistry and Nanomedicine Institute of Molecular Medicine Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200240 China

Funding

National Key Research and Development Program of China · National Natural Science Foundation of China · Basic and Applied Basic Research Foundation of Guangdong Province

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