DataVXAdvanced Functional MaterialsPaper
journal article·2025-09Open access

Joule‐Assisted Nanotherapeutic Urethral Stent (JANUS) for Spatiotemporal Theragenerative Treatment of Urethral Strictures

Yuhyun Na, Yubeen Park, Hyun Lee, Song Hee Kim, Seojoon Bang, Hyeong Seok Kang, Chan Ho Moon, Ju Yeong Gwon, Jong Hwa Seo, Min‐Ho Kang, Soo‐Hong Lee, Gi Doo Cha, Wooram Park, Heemin Kang, Jung‐Hoon Park, Hyun‐Do Jung

Advanced Functional Materials· Volume 35· Issue 37
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Source abstract

Abstract

Abstract Urethral strictures caused by injury, infection, or inflammation present significant clinical challenges, often leading to severe complications such as kidney failure and infertility. A novel spatiotemporal theragenerative platform, the Joule‐assisted nanotherapeutic urethral stent (JANUS), is designed in this study to treat urethral strictures and promote urothelial regeneration. This platform uses a biodegradable magnesium (Mg) alloy stent dual coated with thermoresponsive polycaprolactone (TRP) and sirolimus nanoparticles (nSRL). The dual‐sided coating is optimized for distinct therapeutic and regenerative functions. External magnetic stimuli induce localized hyperthermia via Joule heating, facilitate a controlled nSRL release from the TRP coating, enhance bacterial ablation, and inhibit smooth muscle cell proliferation. Simultaneously, Mg ions released from the stent promote endothelial cell proliferation. JANUS demonstrates significant potential as an effective theragenerative platform, offering a balanced therapy and tissue regeneration approach in treating urethral strictures.
Source: crossref · Quality: baseline

Research context

Metals & alloysNanomaterials

OpenAlex topics: Urological Disorders and Treatments · Ureteral procedures and complications · Urinary Bladder and Prostate Research

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Biomedical‐Chemical Engineering The Catholic University of Korea 43, Jibong‐ro, Wonmi‐gu Bucheon‐si Gyeonggi‐do 14662 Republic of Korea

Department of Biotechnology The Catholic University of Korea 43, Jibong‐ro, Wonmi‐gu Bucheon‐si Gyeonggi‐do 14662 Republic of Korea

Division of Materials Science and Engineering Hanyang University 222, Wangsimni‐ro, Seongdong‐gu Seoul 04763 Republic of Korea

Department of Convergence Medicine Asan Medical Center University of Ulsan College of Medicine 88 Olympic‐ro 43‐gil, Songpa‐gu Seoul 05505 Republic of Korea

Research Institute of Advanced Manufacturing & Materials Technology Korea Instituteof Industrial Technology 156, Gaetbeol‐ro, Yeonsu‐gu Incheon 21999 Republic of Korea

Biomedical Engineering Research Center Asan Institute for Life Sciences Asan Medical Center 88 Olympic‐ro 43‐gil, Songpa‐gu Seoul 05505 Republic of Korea

Department of Bioengineering Hanyang University 222, Wangsimni‐ro Seongdong‐gu Seoul 04763 Republic of Korea

Department of Biomedical Engineering Dongguk University 30, Pildong‐ro 1‐gil, Jung‐gu Seoul 04620 Republic of Korea

Department of Systems Biotechnology Chung‐Ang University 4726, Seodong‐daero, Daedeok‐myeon Anseong‐si Gyeonggi‐do 17546 Republic of Korea

Department of Integrative Biotechnology College of Biotechnology and Bioengineering Sungkyunkwan University Seoburo 2066 Suwon Gyeonggi‐do 16419 Republic of Korea

Department of Materials Science and Engineering Korea University 145, Anam‐ro Seongbuk‐gu Seoul 02841 Republic of Korea

College of Medicine Korea University 145, Anam‐ro, Seongbuk‐gu Seoul 02841 Republic of Korea

Funding

National Research Foundation of Korea · Korea Institute of Marine Science and Technology promotion

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