Enzymatic Redox‐Mediated Fabrication of Textiles with Multimode Synergistic Antimicrobial Activity through Embedding Nanosilver in Dynamic Polydisulfide Networks

Abstract The adhesion and proliferation of bacteria on textiles can lead to unacceptable cross‐infection and potential contamination. Herein, an antimicrobial and anti‐adhesive textile is prepared through enzymatic redox‐mediated fabrication of nanosilver‐embedded polydisulfide networks. Specifically, γ‐methacryloyloxypropyltrimethoxysilane is introduced to cotton fibers to build a reactive hydrophobic layer. Subsequently, α‐lipoic acid‐modified tyramine (mTA) is oxidized using horseradish peroxidase and enzymatically grafted onto the vinylated cotton, producing brown polyphenols containing dynamic disulfide bonds. Ultimately, in situ reduction and entrapment of nanosilver are accomplished by the sulfhydryl groups generated from mTA units, forming an antimicrobial network on fiber surfaces. After contact with bacteria for 30 min or fungi for 3 h, the antibacterial rates of the resulting fabric both reach 99.99%. Benefiting from the encouraging photothermal conversion property, bacteria and fungi on fabric surfaces can be killed after 10 min of irradiation at 100 mW cm ⁻² , demonstrating multimode synergistic antibacterial activity. Strikingly, the fabric has impressively durable antimicrobial and bacterial anti‐adhesive properties, maintaining a high bactericidal efficiency after cyclic bacterial contamination tests. Besides, in situ coloring of the fabric is realized while maintaining its inherent wearability, accompanying by satisfactory biocompatibility and hemocompatibility. The presented work provides novel insights into the design and construction of highly efficient antimicrobial textiles.