DataVXAdvanced Functional MaterialsPaper
journal article·2024-12

Wet Tissue Interfacial Water Triggers Ultrafast In Situ Gelation of Sprayable Dry Powder for Postoperative Anti‐Adhesion

Chaoyao Wen, Yihang Gong, Haoyan Chen, Yu Tian, Hui Yu, Xudan Xin, Le Wang, Chuyang Xiang, Yisheng Chen, Tianhua Xiao, Chengyun Ning, Xuebin Yang, Lei Zhou, Guoxin Tan

Advanced Functional Materials· Volume 34· Issue 49
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Source abstract

Abstract

Abstract Postoperative adhesions complicate the majority of surgical procedures, imposing an excess medical burden. The segregation of injured tissue from healthy tissue is considered the optimal therapeutic strategy. However, achieving hemostasis while preventing adhesions in the immediate postoperative setting continues to pose a significant challenge. This paper presents the in situ formation of an asymmetrically adhesive hydrogel barrier via a sprayable dry powder (SDP) that enables interfacial water‐induced, ultra‐rapid gelation. Owing to SDP hydrophilicity and the interstitial spaces between particles, it can rapidly and efficiently absorb interfacial water, thereby facilitating smooth cross‐linking between material functional groups and tissue functional groups. In addition, SDP becomes less adhesive after gelation as a layer of interfacial water forms on the surface of the SDP hydrogel, enhancing its anti‐adhesion properties. Animal experiment outcomes demonstrate that SDP exhibits significant asymmetric adhesive properties before and after gelation, successfully preventing postoperative adhesions. As a result, SDP heralds a novel approach to the development of adhesives that can simultaneously mitigate adhesions and promptly arrest bleeding.
Source: crossref · Quality: baseline

Research context

Polymers

OpenAlex topics: Surgical Sutures and Adhesives · Intestinal and Peritoneal Adhesions · Hemostasis and retained surgical items

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

School of Chemical Engineering and Light Industry Guangdong University of Technology Guangzhou 510006 P. R. China

Department of Hepatic Surgery and Liver Transplantation Center & Guangdong Provincial Key Laboratory of Liver Disease Research The Third Affiliated Hospital Sun Yat‐sen University Guangzhou 510630 China

School of Materials Science and Engineering National Engineering Research Center for Tissue Restoration and Reconstruction South China University of Technology Guangzhou 510641 China

Guangzhou Key Laboratory of Spine Disease Prevention and Treatment Department of Orthopaedic Surgery Guangdong Provincial Key Laboratory of Major Obstetric Diseases Guangdong Provincial Clinical Medical Research Center for Obstetrics and Gynecology The Third Affiliated Hospital Guangzhou Medical University Guangzhou 510150 P. R. China

Department of General Surgery Lanzhou University Second Hospital The Second Clinical Medical College Lanzhou University Lanzhou Gansu 730000 China

School of Dentistry, St. James's University Hospital University of Leeds Level 7, WTBB Leeds LS9 7TF UK

Funding

Natural Science Foundation of Guangdong Province · National Natural Science Foundation of China

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