Nano‐Interlocking Enhanced Electroactive Dressing: Electromagnetic Induction for Accelerated Diabetic Wound Healing and Wound Microenvironment Monitoring

Abstract The impaired electrophysiological microenvironment of diabetic wounds can be salvaged by electrical stimulation, but clinical application is hindered by a conventional, bulky power supply. Furthermore, the patient's sensory impairment regarding the dangerous state of the wound and non‐visualization increases the difficulty and economic burden of wound care. To address these challenges, an electromagnetic induction‐powered electroactive dressing is developed that enables wireless electrical stimulation therapy and wound microenvironment monitoring. Interestingly, the formed nano‐interlocking structure between Ti ₃ C ₂ T _x MXene and polycaprolactone fibers endows the dressing with superior mechanical performance and stable conductivity (≈3.5 S·cm ⁻¹ , 72.2% retention rate after 7‐day phosphate‐buffered saline immersion), effectively matching practical wound therapy. Under a rotating magnetic field, the dressing can generate wirelessly therapeutic microcurrents (10.8 µA) that activate pro‐healing pathways (calcium, transforming growth factor‐β [TGF‐β], phosphatidylinositol 3‐kinase/protein kinase B [PI3K‐AKT], peroxisome proliferators‐activated receptors [PPAR], Axon guidance, and wingless‐type [Wnt]) while suppressing inflammatory pathways (tumor necrosis factor [TNF] and nuclear factor‐κB [NF‐kappa B]). This dual regulation of cellular behavior and the immune microenvironment accelerates wound healing and nerve regeneration by ≈36.3% and 283.8%, respectively, compared to the control group. The prepared dressing can also monitor the wound's physiological parameters, including temperature, strain, and exudate, enabling timeous and precise wound care. In short, this research promotes the development of electromagnetic induction biomedicine and personalized medicine.