DataVXAdvanced Functional MaterialsPaper
journal article·2025-04

A Bone‐Targeting Hydrogen Sulfide Delivery System for Treatment of Osteoporotic Fracture via Macrophage Reprogramming and Osteoblast‐Osteoclast Coupling

Yi Qin, Zhen Zhang, Xiaobin Guo, Wenhao Li, Wenyu Xia, Gaoran Ge, Yanyue Li, Min Guan, Ang Gao, Lu Mao, Huaiyu Wang, Paul K. Chu, Dechun Geng

Advanced Functional Materials· Volume 35· Issue 17
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Source abstract

Abstract

Abstract The demand for systemic treatment of osteoporotic fractures to reduce recurrence is increasing, but current anti‐osteoporosis medications exhibit unsatisfactory efficacy due to adverse events and limited effects on fracture healing. Herein, a bone‐targeting zeolitic imidazolate framework‐8 (ZIF)‐based hydrogen sulfide (H2S) delivery system (ZIF‐H2S‐SDSSD) is designed to simultaneously promote fracture healing and alleviate osteoporosis. With bone‐targeting peptide SDSSD grafted on the surface, ZIF‐H2S‐SDSSD nanoparticles release H2S in bone tissues without affecting the serum H2S level, thereby mitigating potential risks of systematic H2S delivery. Upon cellular uptake, the acidic environment in lysosomes drives the release of H2S from the encapsulated zinc sulfide in conjunction with the degradation of ZIF. The synergistic effects of released Zn2+ and H2S promote macrophage metabolic reprogramming by suppressing succinate accumulation and mitochondrial reactive oxygen species (mtROS) production, and further regulate osteoblast‐osteoclast coupling. Overall, this strategy holds great promise in the clinical treatment of osteoporotic fractures and broadens the application of nanomedicine therapy for orthopedic diseases.
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Research context

Nanomaterials

OpenAlex topics: Sulfur Compounds in Biology · Bone health and treatments · Nanoplatforms for cancer theranostics

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Orthopedics The First Affiliated Hospital of Soochow University Orthopedic Institute Medical College Soochow University Suzhou Jiangsu 215006 China

Center for Human Tissues and Organs Degeneration Shenzhen Institute of Advanced Technology Chinese Academy of Sciences Shenzhen 518055 China

Department of Orthopedics First Affiliated Hospital of Xinjiang Medical University Urumqi Xinjiang 830054 China

Department of Spine Surgery Zhongda Hospital Southeast University Nanjing Jiangsu 210009 China

The Key Laboratory of Biomedical Imaging Science and System Chinese Academy of Sciences Shenzhen 518055 China

Department of Physics Department of Materials Science and Engineering, and Department of Biomedical Engineering City University of Hong Kong Tat Chee Avenue, Kowloon Hong Kong 999077 China

Funding

National Natural Science Foundation of China · Natural Science Foundation of Jiangsu Province · China Postdoctoral Science Foundation · Shenzhen Science and Technology Innovation Program · Basic and Applied Basic Research Foundation of Guangdong Province

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