journal article·2025-02

Engineered Multifunctional Artificial Dermis for Infected Burn Wound Healing

Zhuoxia Wu, Ming Li, Qianqian Liu, Jing Sun, Chen Tao, Bo Jia, Xiaoyan Sun, Hongjie Zhang, Kai Liu, Fan Wang

Advanced Functional Materials· Volume 35· Issue 8
Publisher page

Abstract

Abstract Burn wound healing is a dynamic and interconnected process, with the complex status of the extracellular matrix (ECM) potentially leading to bacterial infections, drug resistance, or even fatality. However, it remains a grand challenge to assemble a skin‐like material showing similar biological properties as healthy ECM to accelerate burn healing. In this study, the ECM composition is closely mimicked and adaptive multifunctional artificial dermis is developed by leveraging Ag─S bonds, supramolecular interactions among recombinant proteins, Ag+, and hyaluronic acid (HA). The artificial dermis exhibits long‐lasting broad‐spectrum antibacterial activity, achieved though controlled Ag+ release via Ag─S bonds, supramolecular interactions, and recombinant protein‐guided multi‐level assembly, reaching a steady plateau of 83.7% in the later stage. It is found that inflammation is reduced by downregulating IL‐6 and TGF‐β expression. Furthermore, the epidermal growth factor (EGF) within the recombinant proteins stimulates Col1α, ELN, and CD31 upregulation, facilitating ECM remodeling. These adaptive multifunctional artificial dermis effectively address wound infections, accelerate collagen deposition, promote re‐epithelialization, and enhance angiogenesis in infected wounds, highlighting their potential to revolutionize burn wound treatment and offering a promising avenue to holistic care.
Source: crossref · Quality: baseline

Research context

OpenAlex topics: Wound Healing and Treatments · Electrospun Nanofibers in Biomedical Applications · Surgical Sutures and Adhesives

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 China

State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China

Department of Plastic Surgery China‐Japan Union Hospital of Jilin University Changchun 130033 China

Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development School of Chemistry and Molecular Engineering East China Normal University Shanghai 200241 China

School of Mathematics and Statistics Northeast Normal University Changchun 130024 China

Research Center for Tissue Repair and Regeneration affiliated to the Medical Innovation Research Department and 4th Medical Center, PLA General Hospital and PLA Medical College ∣ PLA Key Laboratory of Tissue Repair and Regenerative Medicine and Beijing Key Research Laboratory of Skin Injury, Repair and Regeneration ∣ Research Unit of Trauma Care, Tissue Repair and Regeneration, Chinese Academy of Medical Sciences 2019RU051 Beijing 100048 China

Department of Chemistry Tsinghua University Beijing 100084 China

Xiangfu Laboratory Jiaxing Zhejiang 314102 China

Funding

National Natural Science Foundation of China · Natural Science Foundation of Jilin Province · National Key Research and Development Program of China

References (44)

Show source-provided references
1. 10.1038/s41572-020-0145-510.1038/s41572-020-0145-5 ↗
2. 10.1093/burnst/tkab02110.1093/burnst/tkab021 ↗
3. 10.1093/burnst/tkac04710.1093/burnst/tkac047 ↗
4. 10.1002/adfm.20180138610.1002/adfm.201801386 ↗
5. 10.1002/adfm.20230350910.1002/adfm.202303509 ↗
6. 10.1016/j.ijpharm.2021.12135810.1016/j.ijpharm.2021.121358 ↗
7. 10.1016/j.msec.2019.11006310.1016/j.msec.2019.110063 ↗
8. 10.1021/acsami.1c1874010.1021/acsami.1c18740 ↗
9. 10.1016/j.addr.2017.06.01210.1016/j.addr.2017.06.012 ↗
10. 10.1016/j.eng.2023.07.01310.1016/j.eng.2023.07.013 ↗
11. 10.1021/acsami.0c1894810.1021/acsami.0c18948 ↗
12. 10.1021/acsanm.3c0086210.1021/acsanm.3c00862 ↗
13. Jing S. · CCS Chem. · 2022 · 5 · 1242
14. Jing S. · CCS Chem. · 2020 · 3 · 1669
15. 10.1021/acschembio.3c0014610.1021/acschembio.3c00146 ↗
16. 10.1007/s12274-023-5841-510.1007/s12274-023-5841-5 ↗
17. 10.1007/s12274-023-5838-010.1007/s12274-023-5838-0 ↗
18. 10.1016/j.tibtech.2019.08.00510.1016/j.tibtech.2019.08.005 ↗
19. 10.1016/j.ijbiomac.2023.12400510.1016/j.ijbiomac.2023.124005 ↗
20. Liu W. · Sci. Adv. · 2022 · 8
21. 10.1021/cr300288v10.1021/cr300288v ↗
22. 10.1002/advs.20170052710.1002/advs.201700527 ↗
23. 10.1002/adma.20210061910.1002/adma.202100619 ↗
24. Sun Y. · Fundam. Res. · 2024
25. 10.1002/adma.20230345710.1002/adma.202303457 ↗
26. 10.1002/adfm.20170419510.1002/adfm.201704195 ↗
27. 10.1016/j.jcis.2019.08.08310.1016/j.jcis.2019.08.083 ↗
28. 10.1016/j.ijbiomac.2023.12487210.1016/j.ijbiomac.2023.124872 ↗
29. 10.1002/ange.20190767010.1002/ange.201907670 ↗
30. 10.1002/adfm.20170385210.1002/adfm.201703852 ↗
31. 10.1002/anie.20210193810.1002/anie.202101938 ↗
32. 10.1002/adfm.20220285710.1002/adfm.202202857 ↗
33. 10.1021/acsami.9b0820810.1021/acsami.9b08208 ↗
34. 10.1038/ncomms294110.1038/ncomms2941 ↗
35. 10.1021/acsami.6b0073910.1021/acsami.6b00739 ↗
36. 10.1039/C8NR09818B10.1039/C8NR09818B ↗
37. 10.4172/2155-952X.100027210.4172/2155-952X.1000272 ↗
38. 10.1007/s10924-021-02257-510.1007/s10924-021-02257-5 ↗
39. 10.1111/j.1468-3083.2011.04415.x10.1111/j.1468-3083.2011.04415.x ↗
40. 10.1016/j.isci.2018.12.03810.1016/j.isci.2018.12.038 ↗
41. 10.1111/wrr.1239810.1111/wrr.12398 ↗
42. 10.1111/jdi.1346110.1111/jdi.13461 ↗
43. 10.1021/acsami.9b0172510.1021/acsami.9b01725 ↗
44. 10.1038/aps.2017.16110.1038/aps.2017.161 ↗