journal article·2024-06Open access

Thermally Engineered Ferric Yolk‐Shells for Vaginal Secretion Based Cervical Cancer Screening

Jiao Wu, Yingting Wei, Chunjing Shi, Yida Huang, Zubei Hong, Wanshan Liu, Liying Gu, Ruimin Wang, Yuling Li, Jing Cao, Wen Di, Xumin Hou, Jian Liu, Kun Qian, Lihua Qiu

Advanced Functional Materials· Volume 34· Issue 26

Abstract

Abstract Engineering of materials is crucial for the advanced detection of bio‐molecules, particularly in laser desorption/ionization mass spectrometry (LDI‐MS). However, effective screening with enhanced LDI performance remains challenging due to the lack of engineered substrate materials. Herein, thermally engineered ferric yolk‐shells are designed for enhanced metabolic screening of cervical cancer (CC) using vaginal secretion. A facile thermal engineering strategy is developed to prepare amorphous ferric yolk‐shells with integrated properties. Notably, the amorphous mesoporous yolk‐shells offer signal amplification up to orders of magnitude in LDI‐MS for standard metabolites and diverse bio‐samples. High‐performance CC screening (including identification of human papillomavirus (HPV) infection, high‐grade squamous intraepithelial lesion (HSIL), and CC) is achieved, with the areas under the curve of 0.842–0.963. Finally, a metabolic panel for CC screening, covering the stages of HPV, HSIL, and CC, is established. This work elucidates the LDI‐MS mechanism for enhanced metabolic detection and highlights potential applications in cancer screening.
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Research context

OpenAlex topics: Bone Tissue Engineering Materials · Scientific and Engineering Research Topics · Collagen: Extraction and Characterization

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Shanghai Key Laboratory of Gynecologic Oncology Department of Obstetrics and Gynecology Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200127 P. R. China

State Key Laboratory of Systems Medicine for Cancer School of Biomedical Engineering Institute of Medical Robotics and Shanghai Academy of Experimental Medicine Shanghai Jiao Tong University Shanghai 200030 P. R. China

Division of Cardiology Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200127 P. R. China

Department of Obstetrics and Gynecology Ren Ji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200127 P. R. China

School of Mechanical Engineering Hangzhou Dianzi University Hangzhou 310018 P. R. China

Department of Cardiology Shanghai Chest Hospital of Shanghai Jiao Tong University School of Medicine Shanghai 200030 P. R. China

State Key Laboratory of Catalysis Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian Liaoning 116023 P. R. China

DICP‐Surrey Joint Centre for Future Materials Department of Chemical and Process Engineering and Advanced Technology Institute University of Surrey Guilford Surrey GU2 7XH UK

College of Chemistry and Chemical Engineering Inner Mongolia University Hohhot 010021 China

Funding

National Key Research and Development Program of China · National Natural Science Foundation of China · Science and Technology Commission of Shanghai Municipality

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