DataVXAdvanced Functional MaterialsPaper
journal article·2024-10

Engineering Heterostructured Piezoelectric Nanorods with Rich Oxygen Vacancy‐Mediated Piezoelectricity for Ultrasound‐Triggered Piezocatalytic Cancer Therapy

Wenying Chen, Qi Chen, Feifei Song, Mengying Hua, Meiqi Chang, Wei Feng, Li Ding, Bin Yang, Yu Chen, Zhongqian Hu

Advanced Functional Materials· Volume 34· Issue 41
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Source abstract

Abstract

Abstract Using piezoelectric bionanomaterials to promote the generation of reactive oxygen species (ROS) is being increasingly recognized in ultrasound (US)‐triggered tumor treatments. The mechanism underlying this innovative treatment involves US irradiation, which activates the built‐in electric field (BIEF) and induces energy‐band bending in piezoelectric materials (PEMs). In this study, Sr0.5Ba0.5Nb2O6 (SBN) nanorods (NRs) are synthesized using a molten salt method. Subsequently, oxygen‐vacancy (OV)‐rich SBN/Sr2Nb2O7 (SBN/SNO) heterojunction nanocomposites (NCs) are fabricated via H2 annealing of the SBN NRs. The engineering strategy focused on enhancing ROS generation, thereby augmenting the piezoelectric catalytic activity of the NCs. This configuration ensures that the BIEF and heterojunction‐induced field act synergistically to provide a sustained driving force for the separation of electron‐hole (e−‐h+) pairs. Importantly, the OVs on the surfaces of the H2‐annealed SBN NRs create electron‐rich sites, which substantially enhance their piezocatalytic capabilities. In vitro and in vivo analyses of hepatocellular carcinoma (HCC) models demonstrate the significant cytotoxic and tumor‐inhibitory capabilities of this rich OV‐mediated sonopiezoelectric therapy (SPT) and illustrate its potential as a promising therapeutic approach against cancer.
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Research context

NanomaterialsCatalysis & surfacesMaterials processing

OpenAlex topics: Nanoplatforms for cancer theranostics · Extracellular vesicles in disease · Perovskite Materials and Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Ultrasound The Affiliated Suzhou Hospital of Nanjing Medical University Suzhou Municipal Hospital Suzhou 215001 P. R. China

Department of Ultrasound Jinling Clinical Medical College (General Hospital of Eastern Theater Command) Nanjing Medical University Nanjing 210002 P. R. China

Department of Gastroenterology and Hepatology Zhongshan Hospital Fudan University 180 Fenglin Rd Shanghai 200032 P. R. China

Department of Pathology Shanghai Tenth People's Hospital Tongji University Shanghai 200072 P. R. China

Department of Ultrasound Zhongda Hospital Medical School Southeast University Nanjing 210009 P. R. China

Central Laboratory of Shanghai Municipal Hospital of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine Shanghai 200071 P. R. China

Materdicine Lab School of Life Sciences Shanghai University Shanghai 200444 P. R. China

Department of Medical Ultrasound National Clinical Research Center of Interventional Medicine Shanghai Tenth People's Hospital Tongji University Cancer Center Tongji University School of Medicine Tongji University Shanghai 200072 P. R. China

Shanghai Institute of Materdicine Shanghai 200051 P. R. China

Funding

National Natural Science Foundation of China

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