DataVXAdvanced Functional MaterialsPaper
journal article·2024-10

NIR‐Responsive Multifunctional Artificial Skin for Regenerative Wound Healing

Yiyue Hong, Mengyang Wang, Daorun Hu, Yujia Wang, Shuaifei Ji, Jiangbing Xiang, Hongliang Zhang, Huating Chen, Yan Li, Mingchen Xiong, Wei Pi, Qianyi Wang, Xinling Yang, Yingying Li, Chaochen Shui, Xiaolei Wang, Xiaobing Fu, Xiaoyan Sun

Advanced Functional Materials· Volume 34· Issue 44
Publisher page
Source abstract

Abstract

Abstract Efficient wound repair with skin appendage regeneration following severe trauma poses a challenge due to the scarcity of skin grafts and decreased drug effectiveness in protease‐rich wound microenvironments. Here, a multifunctional artificial skin (NIR‐mFAS) with photothermal‐triggered drug delivery capabilities is designed to actively and comprehensively improve the regenerative potential of full‐thickness wounds. The antibacterial chitosan/silk fibroin hydrogel matrix of artificial skin, cross‐linked by electrostatic interactions, effectively encapsulates and sustains the release of epidermal growth factor (EGF) to accelerate re‐epithelialization and neovascularization by promoting the migration and proliferation of repair cells. Subsequently, the photothermal responsive polydopamine nanoparticles (PDA‐NPs) dispersed in the matrix enable precise control over the release of BMP4 under the irradiation of 1064 nm NIR, thereby inhibiting scarring by reducing myofibroblasts during the proliferative stage. Importantly, the concurrent controlled release of CHIR99021 can modulate cell fate by inducing the conversion of myofibroblasts into dermal papilla‐like cells, leading to hair follicle and sebaceous gland regeneration. The NIR‐mFAS functions as an advanced delivery system for achieving high‐quality wound healing with appendage regeneration and offers a smart therapeutic approach that can be applied to other treatments requiring coordinated delivery of multiple pharmacological agents.
Source: crossref · Quality: baseline

Research context

PolymersNanomaterials

OpenAlex topics: Wound Healing and Treatments · Electrospun Nanofibers in Biomedical Applications · Mesenchymal stem cell research

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Research Center for Tissue Repair and Regeneration affiliated with the Medical Innovation Research Department PLA General Hospital and PLA Medical College State Key Laboratory of Trauma and Chemical Poisoning PLA Key Laboratory of Tissue Repair and Regenerative Medicine and Beijing Key Research Laboratory of Skin Injury Repair and Regeneration Research Unit of Trauma Care Tissue Repair and Regeneration Chinese Academy of Medical Sciences 2019RU051 Beijing 100048 P. R. China

Department of Plastic and Cosmetic Jingzhou Hospital Affiliated to Yangtze University Jingzhou 434000 P. R. China

The National Engineering Research Center for Bioengineering Drugs and the Technologies Institute of Translational Medicine Nanchang University Nanchang 330038 P. R. China

Queen Mary College of Nanchang University Nanchang 330006 P. R. China

State Key Laboratory of Pharmaceutical Biotechnology School of Life Sciences Nanjing University 163 Xianlin Avenue Nanjing 210093 P. R. China

Institute of Basic Medical Sciences Chinese Academy of Medical Sciences School of Basic Medicine Peking Union Medical College Beijing 100730 P. R. China

School of Medicine Chongqing University Chongqing 400030 P. R. China

Tianjin Medical University Tianjin 300070 P. R. China

Funding

National Natural Science Foundation of China · National Key Research and Development Program of China · Natural Science Foundation of Beijing Municipality

References (64)

Show source-provided references
1. 10.1016/j.addr.2022.11467010.1016/j.addr.2022.114670 ↗
2. 10.1016/j.biomaterials.2022.12169810.1016/j.biomaterials.2022.121698 ↗
3. 10.1038/s41467-021-21964-010.1038/s41467-021-21964-0 ↗
4. 10.1016/j.addr.2017.07.01710.1016/j.addr.2017.07.017 ↗
5. 10.1002/advs.20210515210.1002/advs.202105152 ↗
6. 10.1016/j.jid.2021.04.03910.1016/j.jid.2021.04.039 ↗
7. 10.3390/ijms24131043410.3390/ijms241310434 ↗
8. 10.1038/s41928-021-00614-910.1038/s41928-021-00614-9 ↗
9. 10.1016/j.addr.2023.11482110.1016/j.addr.2023.114821 ↗
10. 10.1002/adfm.20210290310.1002/adfm.202102903 ↗
11. 10.1007/s12274-022-5349-410.1007/s12274-022-5349-4 ↗
12. 10.1038/s41467-018-03473-910.1038/s41467-018-03473-9 ↗
13. 10.1021/acsabm.3c0120310.1021/acsabm.3c01203 ↗
14. 10.1016/j.biomaterials.2020.11984710.1016/j.biomaterials.2020.119847 ↗
15. 10.1021/acs.nanolett.9b0097510.1021/acs.nanolett.9b00975 ↗
16. 10.1016/j.mseb.2024.11739210.1016/j.mseb.2024.117392 ↗
17. 10.3390/pharmaceutics1312219810.3390/pharmaceutics13122198 ↗
18. 10.1016/j.molstruc.2023.13554810.1016/j.molstruc.2023.135548 ↗
19. 10.1016/j.ijbiomac.2020.08.04110.1016/j.ijbiomac.2020.08.041 ↗
20. 10.1016/j.bioadv.2023.21356510.1016/j.bioadv.2023.213565 ↗
21. Chen G. · Food Chem. · 2020 · 5
22. 10.1002/smll.20231214010.1002/smll.202312140 ↗
23. 10.1016/j.burns.2017.04.00310.1016/j.burns.2017.04.003 ↗
24. 10.1021/acsapm.2c0219610.1021/acsapm.2c02196 ↗
25. 10.1002/adhm.20160031610.1002/adhm.201600316 ↗
26. 10.1016/j.carbpol.2022.11982410.1016/j.carbpol.2022.119824 ↗
27. 10.1016/j.bioactmat.2021.07.02310.1016/j.bioactmat.2021.07.023 ↗
28. 10.1007/s10311-020-00963-510.1007/s10311-020-00963-5 ↗
29. 10.1016/j.carbpol.2021.11791810.1016/j.carbpol.2021.117918 ↗
30. 10.1016/j.progpolymsci.2023.10174010.1016/j.progpolymsci.2023.101740 ↗
31. 10.3390/cells1012332710.3390/cells10123327 ↗
32. 10.1038/s41467-022-34716-510.1038/s41467-022-34716-5 ↗
33. 10.3389/fmed.2023.106075810.3389/fmed.2023.1060758 ↗
34. 10.1161/CIRCULATIONAHA.120.04960610.1161/CIRCULATIONAHA.120.049606 ↗
35. Sousa F. · J. Controlled Release · 2021 · 4 · 433
36. 10.3390/biom1312170210.3390/biom13121702 ↗
37. 10.1126/sciadv.aba168510.1126/sciadv.aba1685 ↗
38. 10.1038/s41392-021-00762-610.1038/s41392-021-00762-6 ↗
39. 10.3390/ijms2404396110.3390/ijms24043961 ↗
40. 10.1016/j.apmt.2020.10080510.1016/j.apmt.2020.100805 ↗
41. 10.1002/adfm.20230071010.1002/adfm.202300710 ↗
42. 10.1016/j.addr.2018.09.01010.1016/j.addr.2018.09.010 ↗
43. 10.3390/ph1612173910.3390/ph16121739 ↗
44. 10.1021/acsami.1c1920910.1021/acsami.1c19209 ↗
45. 10.1016/j.ijbiomac.2021.03.14710.1016/j.ijbiomac.2021.03.147 ↗
46. 10.1002/adfm.20200943210.1002/adfm.202009432 ↗
47. 10.1021/acs.chemrev.2c0017910.1021/acs.chemrev.2c00179 ↗
48. 10.1039/C9NR03095F10.1039/C9NR03095F ↗
49. 10.1152/physrev.00067.201710.1152/physrev.00067.2017 ↗
50. 10.1126/sciadv.abj015310.1126/sciadv.abj0153 ↗
51. 10.1111/iwj.1262210.1111/iwj.12622 ↗
52. 10.1007/s10456-008-9099-z10.1007/s10456-008-9099-z ↗
53. 10.1182/blood-2013-01-47906310.1182/blood-2013-01-479063 ↗
54. 10.1021/acsami.0c1023610.1021/acsami.0c10236 ↗
55. 10.1126/science.aba237410.1126/science.aba2374 ↗
56. 10.1093/rb/rbad02310.1093/rb/rbad023 ↗
57. 10.1021/acsnano.0c0771410.1021/acsnano.0c07714 ↗
58. 10.1016/j.bioactmat.2022.05.01710.1016/j.bioactmat.2022.05.017 ↗
59. 10.1021/acsnano.1c1101610.1021/acsnano.1c11016 ↗
60. 10.1038/s41563-020-00844-w10.1038/s41563-020-00844-w ↗
61. 10.1186/1756-0500-7-27310.1186/1756-0500-7-273 ↗
62. 10.1111/bph.1543810.1111/bph.15438 ↗
63. 10.1002/adhm.20220090810.1002/adhm.202200908 ↗
64. 10.1038/s41556-018-0073-810.1038/s41556-018-0073-8 ↗