DataVXAdvanced Functional MaterialsPaper
journal article·2024-01

Highly Deformable Double‐Sided Neural Probe with All‐in‐One Electrode System for Real‐Time In Vivo Detection of Dopamine for Parkinson's Disease

Han Hee Jung, Jeongdae Ha, Jeongrak Park, Seongtak Kang, Jinmo Kim, Han Na Jung, Samhwan Kim, Junwoo Yea, Hyeokjun Lee, Saehyuck Oh, Janghwan Jekal, Soojeong Song, Jieun Son, Tae Sang Yu, Youngjeon Lee, Jinyoung Won, Kyung Seob Lim, Yoon Kyeung Lee, Hohyun Keum, Taeyoon Lee, Young Min Song, Jae‐Woong Jeong, Jong‐Cheol Rah, Ji‐Woong Choi, Sheng Xu, Yong‐Seok Oh, Kyung‐In Jang

Advanced Functional Materials· Volume 34· Issue 4
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Source abstract

Abstract

Abstract Precise monitoring of neurotransmitters, such as dopamine (DA), is critical for understanding brain function and treating neurological disorders since dysregulation of DA implicates in a range of disorders, including Parkinson's disease (PD), schizophrenia, and addiction. This study proposes a multi‐deformable double‐sided (MDD) DA‐sensing probe with the three‐electrode system in all‐in‐one form for reliable real‐time monitoring of DA dynamics by integrating working, reference, and counter electrodes on a single probe. The proposed probe achieves high DA sensitivity and selectivity in virtue of enzyme immobilization on the 3D nanostructures grown on working electrode. Also, the serpentine design is employed for the electrodes to withstand in various deformations by achieving high stretchability and manage the stress induced on the probe. Experimental and computational analysis demonstrates an effective reduction in induced‐stress on the electrodes. The MDD DA‐sensing probe is implanted into the brain with success to enable real‐time, in vivo monitoring of DA levels in rodents. Furthermore, DA dynamic changes are monitored before and after treatment with L‐DOPA in hemi‐PD mice. This extremely deformable implantable probe has the potential for use in the study and treatment of neurodegenerative diseases, providing reliable monitoring of DA dynamics with minimal damage to brain tissue.
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Research context

NanomaterialsBiomaterials

OpenAlex topics: Conducting polymers and applications · Neuroscience and Neural Engineering · Electrochemical sensors and biosensors

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Robotics and Mechatronics Engineering Daegu Gyeongbuk Institute of Science and Technology (DGIST) Daegu 42988 Republic of Korea

Brain Engineering Convergence Research Center Daegu Gyeongbuk Institute of Science and Technology (DGIST) Daegu 42988 Republic of Korea

Department of Brain Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Daegu 42988 Republic of Korea

Department of Neurology University of California San Diego La Jolla CA 92093 USA

Department of Electrical Engineering and Computer Science Daegu Gyeongbuk Institute of Science and Technology (DGIST) Daegu 42988 Republic of Korea

Department of Applied Bioengineering Graduate School of Convergence Science and Technology Seoul National University Seoul 08826 Republic of Korea

National Primate Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) Daejeon 28116 Republic of Korea

Futuristic Animal Resource and Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) Daejeon 28116 Republic of Korea

Division of Advanced Materials Engineering Jeonbuk National University Jeonju Jeonbuk 54896 Republic of Korea

Digital Health Care R&D Department Korea Institute of Industrial Technology Cheonan Chungnam 31056 Republic of Korea

School of Electrical and Electronic Engineering Yonsei University Seoul 03722 Republic of Korea

School of Electrical Engineering and Computer Science Gwangju Institute of Science and Technology Gwangju 61005 Republic of Korea

School of Electrical Engineering Korea Advanced Institute of Science and Technology Daejeon 34141 Republic of Korea

Korea Brain Research Institute Daegu 41062 Republic of Korea

Department of Nanoengineering University of California San Diego La Jolla CA 92093 USA

Artificial Intelligence Major in Department of Interdisciplinary Studies Daegu Gyeongbuk Institute of Science and Technology (DGIST) Daegu 42988 Republic of Korea

Funding

Ministry of Science and ICT, South Korea

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