In Situ Sprayed Self‐Gelling Powder Self‐Assembled by a Pure Molecular Drug from Herbal Extract for Rapid Hemostasis and Neuroprotection in Traumatic Brain Injury
Source abstract
Abstract
Abstract Immediate hemostasis and effective treatment are foremost for acute intervention in traumatic brain injury (TBI), but the therapeutic tools and professional treatment methods are often lacking at the scene. Self‐gelling powders formed by the self‐assembly of pure molecular drugs can quickly deliver hemostatic and therapeutic effects without complications from chemical modifications or additional carriers. However, no clinical drugs have been reported as a self‐gelling powder for this purpose. Here, a self‐gelling powder is self‐assembled from sodium aescinate (SA), a drug already approved for treating trauma. To generate SA self‐gelling powder (SA self‐gel‐P), SA powder is heated and cooled in an alkaline solution to form a hydrogel, then freeze‐dried and ground. The obtained SA self‐gel‐P has a good hydrophilicity. When sprayed onto the bleeding site after TBI, it rapidly absorbed blood and formed a gel through intermolecular hydrogen bonding, facilitating effective in situ sealing and rapid hemostasis. Furthermore, the formed hydrogel released SA over a long period, which helped reduce neuronal death, improve integrity of the blood‐brain barrier, reduce brain edema, alleviate neuroinflammation, and ultimately promote recovery of neurofunction without significant toxic side effects. This self‐gelling powder may serve as a powerful auxiliary tool for the pre‐hospital treatment of TBI.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Plant-based Medicinal Research · Intracerebral and Subarachnoid Hemorrhage Research · Traumatic Brain Injury and Neurovascular Disturbances
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Institute of Integrative Medicine, Department of Integrated Traditional Chinese and Western Medicine Xiangya Hospital, Central South University Changsha Hunan 410008 P. R. China
National Clinical Research Center for Geriatric Disorders Xiangya Hospital, Central South University Changsha Hunan 410008 P. R. China
Hunan Provincial Key Laboratory of Micro and Nano Materials Interface Science, College of Chemistry and Chemical Engineering Central South University Changsha 410083 P. R. China
Center for Interdisciplinary Research in Traditional Chinese Medicine Xiangya Hospital, Central South University Changsha 410008 P. R. China
Xiangya Hospital, Central South University Jiangxi (National Reginal Center for Neurological Disease) Nanchang 330004 P. R. China
Engineering Research Center of Innovative Drug of Traditional Chinese and Zhuang Yao Medicine Ministry of Education Guangxi University of Chinese Medicine Nanning 530001 P. R. China
Department of Parasitology School of Basic Medicine Central South University Changsha Hunan 410078 P. R. China
Funding
National Natural Science Foundation of China · China Postdoctoral Science Foundation · Key Research and Development Program of Hunan Province of China
References (79)
Show source-provided references
1. 10.3389/fnins.2023.109067210.3389/fnins.2023.1090672 ↗
2. 10.1111/anae.1589810.1111/anae.15898 ↗
3. 10.1111/trf.1517110.1111/trf.15171 ↗
4. 10.1016/j.clinbiomech.2018.02.01110.1016/j.clinbiomech.2018.02.011 ↗
5. 10.1016/j.nbd.2020.10521010.1016/j.nbd.2020.105210 ↗
6. 10.1111/fcp.1265610.1111/fcp.12656 ↗
7. 10.1186/s12974-020-02005-x10.1186/s12974-020-02005-x ↗
8. 10.1111/anae.1467010.1111/anae.14670 ↗
9. 10.1080/10903127.2023.218790510.1080/10903127.2023.2187905 ↗
10. 10.1007/978-3-030-78075-3_610.1007/978-3-030-78075-3_6 ↗
11. 10.3390/biology1301002110.3390/biology13010021 ↗
12. 10.1002/mabi.20220057710.1002/mabi.202200577 ↗
13. 10.1016/j.powtec.2023.11850110.1016/j.powtec.2023.118501 ↗
14. 10.1016/j.mtbio.2024.10100810.1016/j.mtbio.2024.101008 ↗
15. 10.1002/EXP.2021008910.1002/EXP.20210089 ↗
16. 10.1016/j.jmbbm.2023.10607910.1016/j.jmbbm.2023.106079 ↗
17. 10.3390/polym1613179510.3390/polym16131795 ↗
18. 10.1016/j.carbpol.2022.11957410.1016/j.carbpol.2022.119574 ↗
19. 10.1021/acsami.3c1494410.1021/acsami.3c14944 ↗
20. 10.1002/adma.20160114710.1002/adma.201601147 ↗
21. 10.1016/j.biomaterials.2020.12040310.1016/j.biomaterials.2020.120403 ↗
22. 10.1038/s41467-019-09601-310.1038/s41467-019-09601-3 ↗
23. 10.1002/adhm.20210247610.1002/adhm.202102476 ↗
24. 10.1021/acsabm.9b0100710.1021/acsabm.9b01007 ↗
25. 10.1002/smll.20220552810.1002/smll.202205528 ↗
26. 10.1002/adfm.20240148510.1002/adfm.202401485 ↗
27. 10.1007/s40495-015-0019-910.1007/s40495-015-0019-9 ↗
28. 10.1002/jcph.164410.1002/jcph.1644 ↗
29. Jiang X. · Open Chemistry · 2024 · 22
30. 10.1007/s40820-020-00585-010.1007/s40820-020-00585-0 ↗
31. 10.1002/adfm.20241195910.1002/adfm.202411959 ↗
32. 10.1002/adfm.20231408910.1002/adfm.202314089 ↗
33. 10.1016/j.bioactmat.2023.06.01810.1016/j.bioactmat.2023.06.018 ↗
34. 10.1039/D2CC05507D10.1039/D2CC05507D ↗
35. 10.1002/chem.20120070710.1002/chem.201200707 ↗
36. 10.1002/anie.20141187510.1002/anie.201411875 ↗
37. 10.1038/s41467-024-49933-310.1038/s41467-024-49933-3 ↗
38. 10.1002/adfm.20230393010.1002/adfm.202303930 ↗
39. 10.1002/adfm.20240120910.1002/adfm.202401209 ↗
40. 10.1002/adfm.20210258310.1002/adfm.202102583 ↗
41. 10.1038/natrevmats.2016.6310.1038/natrevmats.2016.63 ↗
42. 10.1126/sciadv.ado391910.1126/sciadv.ado3919 ↗
43. 10.1016/j.bioactmat.2023.08.02110.1016/j.bioactmat.2023.08.021 ↗
44. 10.1016/j.suc.2017.06.00310.1016/j.suc.2017.06.003 ↗
45. 10.1126/sciadv.adh432710.1126/sciadv.adh4327 ↗
46. 10.1002/adfm.20230522210.1002/adfm.202305222 ↗
47. 10.1016/j.jneuroim.2021.57761910.1016/j.jneuroim.2021.577619 ↗
48. Dong R. · Natl. Sci. Rev. · 2022 · 9
49. 10.1039/D1BM01351C10.1039/D1BM01351C ↗
50. 10.3390/biomedicines1203052010.3390/biomedicines12030520 ↗
51. 10.2174/1570159X2066622070609424810.2174/1570159X20666220706094248 ↗
52. 10.1016/j.neubiorev.2017.10.02110.1016/j.neubiorev.2017.10.021 ↗
53. 10.1016/S0387-7604(97)00111-310.1016/S0387-7604(97)00111-3 ↗
54. 10.1016/j.semcdb.2022.05.03010.1016/j.semcdb.2022.05.030 ↗
55. 10.1007/s12035-023-03302-110.1007/s12035-023-03302-1 ↗
56. 10.3390/biom1402018310.3390/biom14020183 ↗
57. 10.1007/s11940-020-0614-x10.1007/s11940-020-0614-x ↗
58. Kiani L. · Nat. Rev. Neurol. · 2022 · 18 · 699
59. 10.1007/978-3-030-39383-0_610.1007/978-3-030-39383-0_6 ↗
60. 10.3390/ijms2105160310.3390/ijms21051603 ↗
61. 10.1002/jnr.2433110.1002/jnr.24331 ↗
62. 10.1016/j.neuropharm.2018.08.00410.1016/j.neuropharm.2018.08.004 ↗
63. 10.1016/j.jneumeth.2019.10834910.1016/j.jneumeth.2019.108349 ↗
64. 10.1016/j.mvr.2023.10451510.1016/j.mvr.2023.104515 ↗
65. 10.1186/s12951-023-01828-z10.1186/s12951-023-01828-z ↗
66. 10.1186/s12987-019-0123-z10.1186/s12987-019-0123-z ↗
67. 10.1016/j.intimp.2022.10890210.1016/j.intimp.2022.108902 ↗
68. 10.3390/ijms2411914410.3390/ijms24119144 ↗
69. 10.1155/2020/424395310.1155/2020/4243953 ↗
70. 10.1016/j.bbi.2021.08.21010.1016/j.bbi.2021.08.210 ↗
71. 10.3390/ijms2212641810.3390/ijms22126418 ↗
72. 10.2147/DNND.S24080010.2147/DNND.S240800 ↗
73. 10.1016/j.neuropharm.2019.10790710.1016/j.neuropharm.2019.107907 ↗
74. 10.3390/molecules2611320810.3390/molecules26113208 ↗
75. 10.1007/s12031-019-01417-610.1007/s12031-019-01417-6 ↗
76. 10.1002/adhm.20200090510.1002/adhm.202000905 ↗
77. 10.1038/s41427-022-00362-y10.1038/s41427-022-00362-y ↗
78. 10.1038/s41392-021-00512-810.1038/s41392-021-00512-8 ↗
79. 10.1016/j.biotechadv.2017.05.00610.1016/j.biotechadv.2017.05.006 ↗