Critical Challenges of Intravenous Nanomaterials Crossing the Blood‐Brain Barrier: from Blood to Brain
Source abstract
Abstract
Abstract Despite recent advancements in the development of blood‐brain barrier (BBB)‐crossing nanomaterials for intravenous administration, there have been very few successful cases in clinical trials. Ongoing challenges within the body impede the precise therapeutic effects of these nanomaterials from reaching their intended target area. Therefore, a comprehensive analysis of the entire pathway that BBB‐crossing nanomaterials must traverse‐from the bloodstream to the brain‐along with an understanding of the obstacles encountered along the way, is essential for advancing these materials to clinical trials. This review begins with a brief overview of the structure and function of the BBB, as well as the pathways and strategies for crossing it. Next, it is discussed and analyzed the common challenges that BBB‐crossing nanomaterials in reaching their target sites in the brain from the bloodstream. To address these challenges, an “eight‐step” guideline strategy is proposed. By leveraging the principles of precision medicine, the design and customization of cascade‐targeted BBB‐crossing nanomaterials that can overcome multiple obstacles show promise for future clinical trials and practical applications. Finally, a perspective on the future direction of this field is offered.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Nanoparticle-Based Drug Delivery · Nanoplatforms for cancer theranostics · Graphene and Nanomaterials Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Institute of Integrative Medicine Department of Integrated Traditional Chinese and Western Medicine Xiangya Hospital, Central South University Changsha 410008 P. R. China
Center for Interdisciplinary Research in Traditional Chinese Medicine Xiangya Hospital, Central South University Changsha 410008 P. R. China
National Clinical Research Center for Geriatric Disorders Xiangya Hospital, Central South University Changsha 410008 P. R. China
Department of Hematology Xiangya Hospital, Central South University Changsha 410008 P. R. China
School of Medicine Hunan University of Chinese Medicine Changsha 410208 P. R. China
Department of Oncology Xiangya Hospital, Central South University Changsha 410008 P. R. China
Hunan Key Laboratory of the Research and Development of Novel Pharmaceutical Preparations Changsha Medical University Changsha 410219 P. R. China
Department of Chemistry Waterloo Institute for Nanotechnology University of Waterloo Waterloo ON N2L 3G1 Canada
Funding
National Natural Science Foundation of China · Fundamental Research Funds for Central Universities of the Central South University · Key Research and Development Program of Hunan Province of China
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