journal article·2024-04Open access

ZIF‐67‐Derived Antivirus Cobalt Hydroxide LDH Nanosheets Produced through High‐Concentration Cobalt Ion‐Assisted Hydration

Ben Wu, Guofang Zhang, Jiawen Ji, Rong‐Hua Luo, Junkang Chen, Feng‐Liang Liu, Emerson Coy, Sergio E. Moya, Qi Li, Xiaoman Suo, Xinyue Chen, Yong‐Tang Zheng, Yang Li, Guocheng Wang

Advanced Functional Materials· Volume 34· Issue 14

Abstract

Abstract In this study, a novel strategy is developed for the first time, referred to as high‐concentration cobalt ion‐assisted hydration (HCCAH) utilizing zeolitic imidazolate framework‐67 (ZIF‐67) as a precursor, to produce independent and flat α‐cobalt hydroxide nanosheets (CHN). These nanosheets offer abundant contact sites for binding with virus surface proteins. The formation of CHN involves the in situ transformation from ZIF‐67, due to the matching of the hydrolysis rate of ZIF‐67 and in situ growth rate of cobalt hydroxide orchestrated by high concentration of cobalt ions. Notably, the CHN contains a higher proportion of trivalent cobalt, which is shown to enhance the binding with the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS‐CoV‐2) Spike protein and induce protein structural denaturation, as demonstrated by molecular dynamics (MD) simulation. Antiviral experiments using pseudovirus and authentic viruses have confirmed the promising antiviral performance of CHN. Furthermore, both in vitro and in vivo experiments have demonstrated the excellent biocompatibility of CHN. This research opens up new possibilities for the application of cobalt hydroxide nanosheets and serves as a valuable reference for the design of antiviral nanomaterials.
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Research context

OpenAlex topics: Metal-Organic Frameworks: Synthesis and Applications · Pneumocystis jirovecii pneumonia detection and treatment · Nanoplatforms for cancer theranostics

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Research Center for Human Tissues and Organs Degeneration Shenzhen Institute of Advanced Technology Chinese Academy of Sciences Shenzhen Guangdong 518055 China

Laboratory of Inflammation and Vaccines Shenzhen Institute of Advanced Technology Chinese Academy of Sciences Shenzhen Guangdong 518055 China

Laboratory of Immunology and Nanomedicine & China‐Italy Joint Laboratory of Pharmacobiotechnology for Medical Immunomodulation Shenzhen Institute of Advanced Technology Chinese Academy of Sciences Shenzhen Guangdong 518055 China

Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province KIZ‐CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases Center for Biosafety Mega‐Science Kunming Institute of Zoology Chinese Academy of Sciences Kunming Yunnan 650223 China

NanoBioMedical Centre Adam Mickiewicz University Wszechnicy Piastowskiej 3 Poznan 61–614 Poland

Center for Cooperative Research in Biomaterials (CIC biomaGUNE) Basque Research and Technology Alliance (BRTA) Paseo Miramon 182 C Donostia/San Sebastian 20014 Spain

Department of Materials Science and Engineering The University of Sheffield Harry Brearley building Portobello Street Sheffield S1 4ND UK

Funding

National Key Research and Development Program of China · National Natural Science Foundation of China · Natural Science Foundation of Guangdong Province

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