DataVXAdvanced Functional MaterialsPaper
journal article·2024-10Open access

An Ultrasound‐Responsive and In Situ Gelling Hydrogel Nanocomposite for Boosting Anti PD‐L1 Immunotherapy via Remodeling Aberrant ECM of Post‐Surgical Residual Cancer

Yuting Cao, Xinyu Zhong, Nianhong Wu, Li Wan, Rui Tang, Hongye He, Can Wang, Hongfeng Cheng, Qin Zhang, Linhong Zhong, Xi Wei, Jianli Ren, Yang Sun, Pan Li

Advanced Functional Materials· Volume 34· Issue 44
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Source abstract

Abstract

Abstract Tumor recurrence and metastasis following surgery remain formidable challenges. Although that is a crucial factor in determining efficacy of postoperative immune treatment, the impact of surgery on tumor microenvironment (TME) is still understudied and the specific treatment options for residual cancer are unsatisfactory. Here, it is verified that abnormal extracellular matrix (ECM) of postsurgical residual cancer results in deteriorative hypoxia, immunosuppression, and hypo‐perfusion, which further promotes invasion and may hinder efficacy of immune checkpoint blockades (ICB). To adaptively potentiate ICB therapy in this context, an ultrasound‐responsive, visualized, and in situ gelling hydrogel nanocomposite (TPP ALG) is prepared through combining phase change nanoparticles and alginate solution for normalizing ECM with controllable delivery of tranilast. After injection and gelling with ions in situ, TPP ALG enables ultrasound visualized and responsive local delivery and long‐term retention, capable of normalizing ECM, improving hypoxia, remodeling immunosuppressive microenvironment, and enhancing ICB permeation for boosting immunotherapy. Ultimately, this TPP ALG and ICB synergistic treatment approach effectively inhibit local recurrence and lung metastasis post operation, thereby delaying survival. Therefore, based on clinical drug and biocompatible materials, the simple‐synthesized hydrogel nanocomposite holds great application prospects for boosting ICB and inhibiting postsurgical cancer recurrence and metastasis.
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Research context

PolymersNanomaterialsBiomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · Nanoparticle-Based Drug Delivery · Cancer Immunotherapy and Biomarkers

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Ultrasound Second Affiliated Hospital of Chongqing Medical University Chongqing 400010 China

Chongqing Key Laboratory of Ultrasound Molecular Imaging Chongqing 400010 China

Department of Ultrasound Third Xiangya Hospital Central South University Changsha Hunan 410013 China

Department of Ultrasound Third Affiliated Hospital of Chongqing Medical University Chongqing 400010 China

Department of Geriatrics Second Affiliated Hospital of Chongqing Medical University Chongqing 400010 P. R. China

Health Management (Physical Examination) Center The Second Affiliated Hospital of Chongqing Medical University Chongqing 400010 P. R. China

Department of Radiology Chongqing Hospital of Traditional Chinese Medicine Chongqing 400010 P. R. China

Department of Diagnostic and Therapeutic Ultrasonography National Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and Therapy Tianjin's Clinical Research Center for Cancer Tianjin Medical University Cancer Institute and Hospital Tianjin 400021 China

State Key Laboratory of Ultrasound in Medicine and Engineering College of Biomedical Engineering Chongqing Medical University Chongqing 400016 China

Funding

National Natural Science Foundation of China · Natural Science Foundation of Chongqing Municipality · Chongqing Graduate Student Research Innovation Project

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