journal article·2024-02

Engineered Microcystis aerugiosa Hydrogel as an Anti‐Tumor Therapeutic by Augmenting Tumor Immunogenicity and Immune Responses

Xiaoyan Meng, Zhonglong Liu, Yangzi Yang, Jiaxin Li, Zhaoyang Ran, Yingchun Zhu, Jingke Fu, Yue He, Yongqiang Hao

Advanced Functional Materials· Volume 34· Issue 7
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Abstract

Abstract Cancer immunotherapy holds great promise but is generally limited by insufficient induction of anticancer immune responses. In this work, Microcystis aerugiosa (MA) is observed to act as an immune stimulator, which activates the cGAS‐STING and IRF‐signaling pathways of dendritic cells (DCs), induces immunostimulatory factors production, eventually resulting in the death of tumor cells by promoting cytotoxic CD8+ T cells infiltration. To further enhance the tumor immunogenicity, MA is engineered with polydopamine (PDA) and assembled in injectable Pluronic F127 hydrogels (denoted as MA@PDA‐F127). The introduction of PDA endows the MA@PDA‐F127 with photothermal therapy capability, which enhances the immunogenicity by in situ exposing damage‐associated molecular patterns and tumor antigens from dying tumor cells. Importantly, the surface‐rich reaction sites in thermosensitive MA@PDA‐F127 hydrogels capture antigens, facilitating long retention of antigens exposure and enhancing DCs maturation for advanced anti‐tumor immune response. Accordingly, in situ administration of MA@PDA‐F127 hydrogels in a single dose achieves efficient eradication of both primary and distant tumors in an orthotopic tumor metastasis model. Furthermore, this hydrogel can sensitize immune checkpoint inhibitor therapy and enhance T cell infiltration in a murine tumor model. Collectively, MA@PDA‐F127 hydrogel offers an effective anti‐tumor therapeutic by augmenting tumor immunogenicity and activating a systematic immune response.
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Research context

OpenAlex topics: Nanoplatforms for cancer theranostics · Immune cells in cancer · Cancer Research and Treatments

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Oral Maxillofacial & Head and Neck Oncology Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200011 P. R. China

College of Stomatology Shanghai Jiao Tong University Shanghai 200011 P. R. China

National Center for Stomatology National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of Stomatology Shanghai Jiao Tong University School of Medicine Shanghai 200011 P. R. China

Department of Orthopedic Surgery Spine Center Changzheng Hospital Navy Medical University No. 415 Fengyang Road Shanghai 200003 China

Department of Orthopedics The Second Affiliated Hospital of Harbin Medical University 246 Xuefu Road Harbin 150001 China

Shanghai Key Laboratory of Orthopaedic Implant Department of Orthopaedic Surgery Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200011 P. R. China

Clinical and Translational Research Center for 3D Printing Technology Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200011 P. R. China

Shanghai Engineering Research Center of Innovative Orthopaedic Instruments and Personalized Medicine Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200011 P. R. China

Key Laboratory of Inorganic Coating Materials Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 P. R. China

Funding

National Natural Science Foundation of China · Shanghai Municipal Health Commission · Key Technologies Research and Development Program · School of Medicine, Shanghai Jiao Tong University

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