Chiral Engineered Biomaterials: New Frontiers in Cellular Fate Regulation for Regenerative Medicine
Source abstract
Abstract
Abstract Chirality, the property of objects that are nonsuperimposable on their mirror images, plays a crucial role in biological processes and cellular behaviors. Chiral engineered biomaterials have emerged as a promising approach to regulating cellular fate in regenerative medicine. However, few reviews provide a comprehensive examination of recent advancements in chiral biomaterials and their applications in cellular fate regulation. Herein, various fabrication techniques available for chiral biomaterials, including the use of chiral molecules, surface patterning, and self‐assembly are discussed. The mechanisms through which chiral biomaterials influence cellular responses, such as modulation of adhesion receptors, intracellular signaling, and gene expression, are explored. Notably, chiral biomaterials have demonstrated their ability to guide stem cell differentiation and augment tissue‐specific functions. The potential applications of chiral biomaterials in musculoskeletal disorders, neurodegenerative diseases, cardiovascular diseases, and wound healing are highlighted. Challenges and future perspectives, including standardization of fabrication methods and translation to clinical settings, are addressed. In conclusion, chiral engineered biomaterials offer exciting prospects for precisely controlling cellular fate, advancing regenerative medicine, and enabling personalized therapeutic strategies.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: 3D Printing in Biomedical Research · Pluripotent Stem Cells Research · Nanoparticle-Based Drug Delivery
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Biomedical Engineering The Chinese University of Hong Kong Shatin, N.T. Hong Kong SAR China
Institute of Sports Medicine Beijing Key Laboratory of Sports Injuries Peking University Third Hospital Beijing 100191 China
Department of Orthopaedic Surgery Center for Orthopaedic Surgery The Third Affiliated Hospital of Southern Medical University Guangzhou 510630 China
Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases Guangzhou 510630 China
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety New Cornerstone Science Laboratory National Center for Nanoscience and Technology Beijing 100190 China
University of Chinese Academy of Sciences Beijing 100049 China
Department of Chemistry The Chinese University of Hong Kong Shatin Hong Kong SAR China
School of Biomedical Sciences The Chinese University of Hong Kong Shatin, N.T. Hong Kong SAR China
Institute for Tissue Engineering and Regenerative Medicine The Chinese University of Hong Kong Shatin, N.T. Hong Kong SAR China
Shun Hing Institute of Advanced Engineering The Chinese University of Hong Kong Shatin, N.T. Hong Kong SAR China
Shenzhen Research Institute The Chinese University of Hong Kong No.10, 2nd Yuexing Road, Nanshan Shenzhen Guangdong Province 518057 China
Funding
National Natural Science Foundation of China · Innovation and Technology Commission - Hong Kong · Shun Hing Institute of Advanced Engineering · Chinese University of Hong Kong
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