DataVXAdvanced Functional MaterialsPaper
journal article·2024-09

3D Cryo‐Printed Hierarchical Porous Scaffolds Harmonized with Hybrid Nanozymes for Combinatorial Mitochondrial Therapy: Enhanced Diabetic Bone Regeneration via Micromilieu Remodeling

Qing‐Song Deng, Xu‐Ran Li, Po‐Lin Liu, Shu‐Hang He, Yuan Gao, Zi‐Yin Han, Zhi‐Han Shen, Zhan‐Ying Wei, Chang‐Ru Zhang, Fei Wang, Helen Dawes, Tong‐He Zhu, Shang‐Chun Guo, Shi‐Cong Tao

Advanced Functional Materials· Volume 34· Issue 39
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Source abstract

Abstract

Abstract Regeneration of bone defects in diabetic patients has always been a significant challenge in clinical treatment. The pathologic diabetic micromilieu, characterized by mitochondrial dysfunction, excessive reactive oxygen species (ROS) accumulation, cellular senescence, and chronic inflammation, compromises innate bone healing capacity. 3D cryo‐printing technology is utilized in bone tissue engineering to fabricate hierarchical porous scaffolds that promote a conducive microenvironment for cellular adhesion, migration, proliferation, and nutrient exchange. Nanozymes are used as synthetic mimics of natural enzymes to scavenge ROS, addressing the limitations of natural antioxidative enzymes. To remodel the diabetic bone regeneration micromilieu, a 3D cryo‐printed polyaryletherketone with carboxyl groups (PAEK‐COOH) and 45S5 bioactive glass (BG) hierarchical porous scaffold (PBG scaffold), harmonized with hybrid nanozymes comprising SS31‐enhanced manganese dioxide (MnO2)‐ferritin biomimetic nanozyme (MF@S nanozyme), is developed for combinatorial mitochondrial therapy. The MF@S nanozyme specifically targets mitochondria to enhance mitochondrial function, scavenge ROS accumulated in mitochondria, and suppress mitochondrial ROS (mtROS) production, and thus rejuvenate aging cells, regulate macrophage polarization, and modulate differentiation of osteoblasts and osteoclasts. This 3D cryo‐printed PBG‐MF@S hierarchical porous scaffold combines with a combinatorial mitochondrial therapy system to remodel the diabetic micromilieu and presents a promising therapeutic approach for the regeneration of bone defects in diabetes.
Source: crossref · Quality: baseline

Research context

Ceramics & glassesNanomaterialsBiomaterials

OpenAlex topics: Advanced Nanomaterials in Catalysis · Bone Tissue Engineering Materials · Nanoplatforms for cancer theranostics

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Orthopedic Surgery Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine 600 Yishan Road Shanghai 200233 China

School of Medicine Shanghai Jiao Tong University 227 South Chongqing Road Shanghai 200025 China

Institute of Microsurgery on Extremities Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine 600 Yishan Road Shanghai 200233 China

School of Nursing Nanjing Medical University 101 Longmian Avenue, Jiangning District Nanjing 211166 China

Shanghai Clinical Research Centre of Bone Diseases Department of Osteoporosis and Bone Diseases Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai 200233 China

Shanghai Key Laboratory of Orthopedic Implants Department of Orthopedic Surgery Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine No. 639 Zhizaoju Road Shanghai 200011 China

Clinical and Translational Research Center for 3D Printing Technology Medical 3D Printing Innovation Research Center Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200125 China

Department of Orthopedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopedics Ruijin Hospital, Shanghai Jiao Tong University School of Medicine 197 Ruijin Second Road Shanghai 200025 China

Faculty of Health and Life Science Oxford Brookes University Headington Road Oxford OX3 0BP UK

NIHR Oxford Health Biomedical Research Centre Oxford OX3 7JX UK

College of Medicine and Health St Lukes Campus University of Exeter Heavitree Road Exeter EX1 2LU UK

School of Chemistry and Chemical Engineering, Shanghai Engineering Research Center of Pharmaceutical Intelligent Equipment, Shanghai Frontiers Science Research Center for Druggability of Cardiovascular Non‐Coding RNA, Institute for Frontier Medical Technology Shanghai University of Engineering Science Shanghai 201620 China

Funding

National Natural Science Foundation of China

References (95)

Show source-provided references
1. 10.1016/j.diabres.2019.10784310.1016/j.diabres.2019.107843 ↗
2. 10.1016/j.biomaterials.2022.12190010.1016/j.biomaterials.2022.121900 ↗
3. 10.1021/acsami.2c0227810.1021/acsami.2c02278 ↗
4. 10.1016/j.biomaterials.2022.12173210.1016/j.biomaterials.2022.121732 ↗
5. 10.1002/adfm.20210137210.1002/adfm.202101372 ↗
6. 10.1038/s41574-021-00555-510.1038/s41574-021-00555-5 ↗
7. 10.1016/j.molmed.2019.04.00810.1016/j.molmed.2019.04.008 ↗
8. 10.1002/advs.20210177810.1002/advs.202101778 ↗
9. 10.1038/s41574-021-00626-710.1038/s41574-021-00626-7 ↗
10. 10.1002/jcp.2064110.1002/jcp.20641 ↗
11. 10.1002/adfm.20221266910.1002/adfm.202212669 ↗
12. 10.1002/adma.20210864610.1002/adma.202108646 ↗
13. 10.1002/btm2.1039810.1002/btm2.10398 ↗
14. 10.1016/j.jmst.2023.01.05510.1016/j.jmst.2023.01.055 ↗
15. 10.1016/j.biomaterials.2012.12.02310.1016/j.biomaterials.2012.12.023 ↗
16. 10.1007/s12015-018-9809-x10.1007/s12015-018-9809-x ↗
17. 10.1002/adma.20210843010.1002/adma.202108430 ↗
18. 10.1590/1678-77572016003710.1590/1678-775720160037 ↗
19. 10.1038/nature0132210.1038/nature01322 ↗
20. 10.1155/2016/298907610.1155/2016/2989076 ↗
21. 10.1007/s11357-012-9440-810.1007/s11357-012-9440-8 ↗
22. 10.1038/s41569-022-00739-010.1038/s41569-022-00739-0 ↗
23. 10.1021/acs.chemrev.8b0067210.1021/acs.chemrev.8b00672 ↗
24. 10.1002/adma.20200746510.1002/adma.202007465 ↗
25. 10.1039/C8CS00718G10.1039/C8CS00718G ↗
26. 10.1002/anie.20181377110.1002/anie.201813771 ↗
27. 10.1002/adma.20211035210.1002/adma.202110352 ↗
28. 10.1021/acsnano.8b0539910.1021/acsnano.8b05399 ↗
29. 10.1002/adma.20200657010.1002/adma.202006570 ↗
30. 10.1016/j.jare.2021.02.00410.1016/j.jare.2021.02.004 ↗
31. 10.1016/j.addr.2021.11389210.1016/j.addr.2021.113892 ↗
32. 10.1016/j.biomaterials.2019.04.03410.1016/j.biomaterials.2019.04.034 ↗
33. 10.1021/acsnano.2c0731110.1021/acsnano.2c07311 ↗
34. 10.1016/j.bioactmat.2023.04.00410.1016/j.bioactmat.2023.04.004 ↗
35. 10.1126/sciadv.abb742210.1126/sciadv.abb7422 ↗
36. 10.1038/clpt.2014.17410.1038/clpt.2014.174 ↗
37. 10.1021/acsnano.2c0579510.1021/acsnano.2c05795 ↗
38. 10.1021/acs.chemrev.0c0014510.1021/acs.chemrev.0c00145 ↗
39. 10.1016/j.bioactmat.2021.02.03310.1016/j.bioactmat.2021.02.033 ↗
40. 10.1016/j.biomaterials.2018.10.03310.1016/j.biomaterials.2018.10.033 ↗
41. 10.1016/j.mtadv.2022.10025910.1016/j.mtadv.2022.100259 ↗
42. 10.1016/j.bioactmat.2020.12.00910.1016/j.bioactmat.2020.12.009 ↗
43. 10.1088/1758-5090/ac84b010.1088/1758-5090/ac84b0 ↗
44. 10.1016/j.biomaterials.2007.07.01310.1016/j.biomaterials.2007.07.013 ↗
45. 10.1002/adhm.20220097710.1002/adhm.202200977 ↗
46. 10.1002/admt.20220167610.1002/admt.202201676 ↗
47. 10.1016/j.actbio.2015.07.01910.1016/j.actbio.2015.07.019 ↗
48. 10.1007/s10856-008-3635-710.1007/s10856-008-3635-7 ↗
49. 10.1111/bph.1246110.1111/bph.12461 ↗
50. 10.7554/eLife.6082710.7554/eLife.60827 ↗
51. 10.1038/s43587-023-00360-x10.1038/s43587-023-00360-x ↗
52. 10.1002/SMMD.2023003010.1002/SMMD.20230030 ↗
53. 10.1126/sciadv.aaz782210.1126/sciadv.aaz7822 ↗
54. 10.7150/thno.3759910.7150/thno.37599 ↗
55. 10.1016/j.biomaterials.2020.12030210.1016/j.biomaterials.2020.120302 ↗
56. 10.1016/j.cej.2021.13080610.1016/j.cej.2021.130806 ↗
57. 10.1016/j.bioactmat.2021.09.00110.1016/j.bioactmat.2021.09.001 ↗
58. 10.1016/j.biomaterials.2022.12146510.1016/j.biomaterials.2022.121465 ↗
59. 10.1038/nature1111710.1038/nature11117 ↗
60. 10.1155/2013/32912110.1155/2013/329121 ↗
61. 10.1039/c3cs35486e10.1039/c3cs35486e ↗
62. 10.1039/C8CS00457A10.1039/C8CS00457A ↗
63. 10.1021/ja00707a06210.1021/ja00707a062 ↗
64. 10.1002/adma.20180536810.1002/adma.201805368 ↗
65. 10.3390/s2016450910.3390/s20164509 ↗
66. 10.1002/adhm.20230207310.1002/adhm.202302073 ↗
67. 10.1016/j.jconrel.2019.09.00210.1016/j.jconrel.2019.09.002 ↗
68. 10.1073/pnas.140780811110.1073/pnas.1407808111 ↗
69. 10.1002/adma.20210699610.1002/adma.202106996 ↗
70. 10.1016/j.bmt.2023.11.00110.1016/j.bmt.2023.11.001 ↗
71. 10.1002/smll.20220806310.1002/smll.202208063 ↗
72. 10.1016/j.bioactmat.2022.05.01110.1016/j.bioactmat.2022.05.011 ↗
73. 10.1002/mabi.20190027110.1002/mabi.201900271 ↗
74. 10.3390/ma1304099910.3390/ma13040999 ↗
75. 10.1016/j.bmt.2023.11.00210.1016/j.bmt.2023.11.002 ↗
76. 10.1016/j.biomaterials.2021.12084110.1016/j.biomaterials.2021.120841 ↗
77. 10.1093/stcltm/szac00410.1093/stcltm/szac004 ↗
78. 10.1038/nature1177610.1038/nature11776 ↗
79. 10.1002/biof.19710.1002/biof.197 ↗
80. 10.1152/physrev.00026.201310.1152/physrev.00026.2013 ↗
81. 10.1016/j.arr.2023.10195510.1016/j.arr.2023.101955 ↗
82. 10.3109/10715762.2013.82120010.3109/10715762.2013.821200 ↗
83. 10.1002/smll.20220691910.1002/smll.202206919 ↗
84. 10.1021/acsnano.3c0240710.1021/acsnano.3c02407 ↗
85. 10.1016/j.bioactmat.2023.03.00510.1016/j.bioactmat.2023.03.005 ↗
86. 10.1007/s00018-022-04186-510.1007/s00018-022-04186-5 ↗
87. 10.1016/j.bioactmat.2020.12.02010.1016/j.bioactmat.2020.12.020 ↗
88. 10.1016/j.bioactmat.2023.05.01810.1016/j.bioactmat.2023.05.018 ↗
89. 10.1016/j.bioactmat.2023.01.02410.1016/j.bioactmat.2023.01.024 ↗
90. 10.1016/j.semcdb.2016.02.01110.1016/j.semcdb.2016.02.011 ↗
91. 10.1016/j.freeradbiomed.2005.10.06610.1016/j.freeradbiomed.2005.10.066 ↗
92. 10.7150/thno.3541410.7150/thno.35414 ↗
93. 10.1016/j.cej.2023.14661510.1016/j.cej.2023.146615 ↗
94. 10.1002/adfm.20220106710.1002/adfm.202201067 ↗
95. Gong L. · Ann. Clin. Lab. Sci. · 2016 · 46 · 65