DataVXAdvanced Functional MaterialsPaper
journal article·2024-11Open access

Atomic Interface Engineering‐Mediated Metallene Nanozyme Boosts Efficient Photothermal Catalytic Tumor‐Specific Therapy

Jiandong Wu, Dongxu Jiao, Qihui Liu, Bin Tian, Tao Liu, Qiong Wu, Yu Nan, Xin Chang, Shan Jiang, Qi Yang, Xiaoqiang Cui, Fangfang Chen

Advanced Functional Materials· Volume 34· Issue 46
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Source abstract

Abstract

Abstract Tumor microenvironment (TME)‐responsive nanozymes‐based catalytic therapy shows great potential in combating malignant tumor. However, their biological application still suffers from deficient catalytic activity. Herein, the MoOx‐Rh metallene nanozyme demonstrates highly efficient multiple enzymatic catalytic activities, where MoOx species atomically dispersed on Rh metallene surface. The resulting structures enable MoOx‐Rh metallene with maximally exposed active oxide‐metallene interface and more atoms sites around interface can be well finely regulated. Results of experiment and density functional theory (DFT) simulations support the notion that atomic interface structure facilitates multiple enzyme‐like reactions. As a TME‐responsive nanozyme, MoOx‐Rh metallene exhibits remarkable therapeutic effect of tumor due to intrinsic near‐infrared photothermal effect and laser‐enhanced multiple enzymatic catalytic activities. This study illustrates the great promise of atomic interface engineering strategy in tumor catalytic therapy.
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Research context

NanomaterialsCatalysis & surfaces

OpenAlex topics: Advanced Nanomaterials in Catalysis · Nanoplatforms for cancer theranostics · Nanocluster Synthesis and Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Key Laboratory of Pathobiology Ministry of Education Nanomedicine and Translational Research Center Electron Microscopy Center China‐Japan Union Hospital of Jilin University No.126 Sendai Street Changchun 130033 China

State Key Laboratory of Automotive Simulation and Control Key Laboratory of Automobile Materials Ministry of Education School of Materials Science and Engineering Jilin University No.2699 Qianjin Street Changchun 130012 China

Department of Obstetrics and Gynecology Second Hospital of Jilin University No.4026 Yatai Street Changchun 130041 China

Department of Breast Surgery Second Hospital of Jilin University No.4026 Yatai Street Changchun 130041 China

Funding

National Key Research and Development Program of China · National Natural Science Foundation of China · China Postdoctoral Science Foundation · Natural Science Foundation of Jilin Province · Program for Jilin University Science and Technology Innovative Research Team

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