DataVXAdvanced Functional MaterialsPaper
journal article·2024-03Open access

Bioprinted Organoids Platform with Tumor Vasculature for Implementing Precision Personalized Medicine Targeted Towards Gastric Cancer

Jisoo Kim, Jungmin Kim, Ge Gao, Yoo‐mi Choi, Jaewook Kim, Dong‐Woo Cho, Jae‐Ho Cheong, Jinah Jang

Advanced Functional Materials· Volume 34· Issue 11
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Source abstract

Abstract

Abstract Accurate prediction of treatment response for cancer patients is essential for overcoming intrinsic therapy resistance that results from genetic heterogeneity, varying tumor growth kinetics, and the complex tumor microenvironment. To achieve this goal, there is an urgent need for effective preclinical in vitro models that recapitulate the molecular–pathologic features and intricate ecology of native tumors for precision medicine. In this study, a vascularized organoid model (VOM) composed of patient‐derived gastric cancer organoids (PDOs), perfusable endothelium, and stomach decellularized extracellular matrix is presented that enables the prediction of clinical response to VEGFR2‐targeted therapy in gastric cancer patients. The results indicate that VOMs are dependent on the PDO molecular subtype. Moreover, VOMs accurately reproduce the clinically observed responses of patients treated with VEGFR2 inhibitor. Therefore, VOMs represent a valuable platform for providing clinical predictions for personalized testing and potential discovery of therapeutic drugs in various cancers that lack standardized regimens.
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Research context

OpenAlex topics: Cancer Cells and Metastasis · 3D Printing in Biomedical Research · Cancer Genomics and Diagnostics

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

School of Interdisciplinary Bioscience and Bioengineering Pohang University of Science and Technology (POSTECH) Pohang 37673 South Korea

Department of Surgery Yonsei University College of Medicine Seoul 03722 South Korea

School of Medical Technology Beijing Institute of Technology Beijing China

Department of Creative IT Engineering Pohang University of Science and Technology (POSTECH) Pohang 37673 South Korea

Department of Mechanical Engineering Pohang University of Science and Technology (POSTECH) Pohang 37673 South Korea

Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Seoul 03722 South Korea

Graduate School of Medical Science Brain Korea 21 Project Yonsei University College of Medicine Seoul 03722 South Korea

Chronic Intractable Disease for Systems Medicine Research Center Yonsei University College of Medicine Seoul 03722 South Korea

Department of Biomedical Systems Informatics Yonsei University College of Medicine Seoul 03722 South Korea

Funding

Ministry of Science, ICT and Future Planning · Ministry of Science and ICT, South Korea · National Cancer Center · Ministry of Trade, Industry and Energy · Ministry of Health and Welfare

References (58)

Show source-provided references
1. 10.1021/acs.chemrev.0c0038310.1021/acs.chemrev.0c00383 ↗
2. 10.4254/wjh.v7.i5.78710.4254/wjh.v7.i5.787 ↗
3. 10.1007/s00280-015-2861-110.1007/s00280-015-2861-1 ↗
4. 10.1016/j.ccell.2020.09.01410.1016/j.ccell.2020.09.014 ↗
5. 10.1016/S0140-6736(20)31288-510.1016/S0140-6736(20)31288-5 ↗
6. 10.1056/NEJMoa200441310.1056/NEJMoa2004413 ↗
7. 10.1007/s10120-014-0402-y10.1007/s10120-014-0402-y ↗
8. 10.1093/annonc/mdn16910.1093/annonc/mdn169 ↗
9. 10.1093/annonc/mdi06410.1093/annonc/mdi064 ↗
10. 10.1038/s41467-022-28437-y10.1038/s41467-022-28437-y ↗
11. 10.1016/S1470-2045(18)30108-610.1016/S1470-2045(18)30108-6 ↗
12. 10.1038/s41467-018-04179-810.1038/s41467-018-04179-8 ↗
13. 10.1016/S0959-8049(02)00013-810.1016/S0959-8049(02)00013-8 ↗
14. 10.1016/S1470-2045(14)70420-610.1016/S1470-2045(14)70420-6 ↗
15. 10.1016/S0140-6736(13)61719-510.1016/S0140-6736(13)61719-5 ↗
16. 10.1002/cac2.1219310.1002/cac2.12193 ↗
17. 10.1016/j.dld.2022.03.00110.1016/j.dld.2022.03.001 ↗
18. 10.1038/s41551-019-0363-x10.1038/s41551-019-0363-x ↗
19. 10.1002/smll.20190432110.1002/smll.201904321 ↗
20. 10.1007/s13770-020-00258-410.1007/s13770-020-00258-4 ↗
21. 10.1021/acs.chemrev.9b0080810.1021/acs.chemrev.9b00808 ↗
22. 10.1038/s41568-018-0007-610.1038/s41568-018-0007-6 ↗
23. 10.1038/s41563-021-01057-510.1038/s41563-021-01057-5 ↗
24. 10.1038/ncb331210.1038/ncb3312 ↗
25. 10.1093/jnci/djp05810.1093/jnci/djp058 ↗
26. 10.1016/j.ajpath.2013.11.01210.1016/j.ajpath.2013.11.012 ↗
27. 10.1038/s41551-020-00657-x10.1038/s41551-020-00657-x ↗
28. 10.1016/j.jsb.2009.05.00510.1016/j.jsb.2009.05.005 ↗
29. 10.1016/j.mehy.2008.09.01010.1016/j.mehy.2008.09.010 ↗
30. 10.7150/jca.1846610.7150/jca.18466 ↗
31. 10.1001/jamasurg.2018.524910.1001/jamasurg.2018.5249 ↗
32. 10.1038/s41388-018-0209-010.1038/s41388-018-0209-0 ↗
33. 10.1038/s41568-019-0168-y10.1038/s41568-019-0168-y ↗
34. 10.4251/wjgo.v11.i7.50910.4251/wjgo.v11.i7.509 ↗
35. 10.1016/j.drudis.2018.01.03610.1016/j.drudis.2018.01.036 ↗
36. 10.1007/BF0004636410.1007/BF00046364 ↗
37. 10.1002/path.303110.1002/path.3031 ↗
38. 10.3389/fbioe.2021.60581910.3389/fbioe.2021.605819 ↗
39. 10.1242/jcs.02382010.1242/jcs.023820 ↗
40. 10.1002/smll.20200475010.1002/smll.202004750 ↗
41. 10.1002/hep.2410810.1002/hep.24108 ↗
42. 10.1002/ijc.3122110.1002/ijc.31221 ↗
43. 10.1021/acsbiomaterials.8b0123010.1021/acsbiomaterials.8b01230 ↗
44. 10.1146/annurev-bioeng-061008-12491510.1146/annurev-bioeng-061008-124915 ↗
45. 10.1038/ncomms384210.1038/ncomms3842 ↗
46. 10.1002/hep.2799210.1002/hep.27992 ↗
47. Chappell J. C. · 2011 · 1005
48. 10.1038/nrm317610.1038/nrm3176 ↗
49. 10.1158/0008-5472.CAN-19-156410.1158/0008-5472.CAN-19-1564 ↗
50. 10.1039/C9LC00140A10.1039/C9LC00140A ↗
51. Takahashi Y. · Clin. Cancer Res. · 1996 · 2 · 1679
52. Li X. · Oncol. Lett. · 2019 · 18 · 4891
53. 10.1155/2010/46872510.1155/2010/468725 ↗
54. Tannock I. · J. Natl Cancer Inst. · 1969 · 42 · 771
55. Cancer Genome Atlas Research Network Nature2014 513 202 https://doi.org/10.1038/nature13480.10.1038/nature13480 ↗
56. 10.1186/s12885-019-5322-010.1186/s12885-019-5322-0 ↗
57. 10.1016/j.jconrel.2016.11.01510.1016/j.jconrel.2016.11.015 ↗
58. 10.1038/ncomms493510.1038/ncomms4935 ↗