journal article·2024-02

Oxygen‐Free Polycationic Photosensitizers for Treatment of Periodontal Inflammation

Yuping Qian, Yujie Sun, Ludan Zhang, Yiwen Zhu, Ningyu Li, Fan Dong, Chen Xu, Na An, Hu Chen, Yuchun Sun, Bingran Yu, Yuguang Wang, Fu‐Jian Xu

Advanced Functional Materials· Volume 34· Issue 7
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Abstract

Abstract Periodontal tissue infection is a chronic destructive inflammatory disease caused by bacteria including anaerobes and facultative anaerobes. Traditional mechanical debridement and antibiotic treatments are not effective at removing biofilm from the root surface, resulting in recurrent disease. Antimicrobial photodynamic therapy (aPDT) is a promising bactericidal method, but it is limited by oxygen content. Here, an oxygen‐free cationic polymer (HQRB‐SS‐Dex) containing the photosensitizer rose bengal (RB) and dextran is proposed. It releases both 1O2 and HO•, and it exhibits strong antibacterial efficiency against periodontal pathogenic bacteria under irradiation. The positively charged quaternary ammonium polymer and dextran of HQRB‐SS‐Dex facilitate adherence to the bacterial surface and penetration of the bacterial biofilm to permit efficient use of reactive oxygen species. Disulfide bonds make the complex biodegradable, which improves biosafety. This work presents a unique branched cationic polymer for oxygen‐free aPDT, with potential application to the treatment of periodontal infection.
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Research context

OpenAlex topics: Nanoplatforms for cancer theranostics · Photodynamic Therapy Research Studies · Oral microbiology and periodontitis research

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Center of Digital Dentistry School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices No.22 Peking University Zhongguancun South Avenue, Haidian Beijing 100081 China

Key Lab of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology, Ministry of Education) and Laboratory of Biomedical Materials College of Materials Science and Engineering Beijing University of Chemical Technology Beijing 100029 China

Department of General Dentistry II School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices No.22 Peking University Zhongguancun South Avenue, Haidian Beijing 100081 China

Funding

National Natural Science Foundation of China · China Postdoctoral Science Foundation

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