DataVXAdvanced Functional MaterialsPaper
journal article·2024-02Open access

MRI‐Compatible, Transparent PEDOT:PSS Neural Implants for the Alleviation of Neuropathic Pain with Motor Cortex Stimulation

Young Uk Cho, Kyeongmin Kim, Ankan Dutta, Sang Hoon Park, Ju Young Lee, Hyun Woo Kim, Jieon Park, Jiwon Kim, Won Kyung Min, Chihyeong Won, Jaejin Park, Yujin Kim, Guanghai Nan, Jong Youl Kim, Taeyoon Lee, Hyun Jae Kim, Donghyun Kim, Jong Eun Lee, Byung‐Wook Min, Il‐Joo Cho, Bae Hwan Lee, Huanyu Cheng, Myeounghoon Cha, Ki Jun Yu

Advanced Functional Materials· Volume 34· Issue 6
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Source abstract

Abstract

Abstract Simultaneous monitoring of electrophysiology and magnetic resonance imaging (MRI) could guide the innovative diagnosis and treatment of various neurodegenerative diseases that are previously impossible. However, this technique is difficult because the existing metal‐based implantable neural interface for electrophysiology is not free from signal distortions from its intrinsic magnetic susceptibility while performing an MRI of the implanted area of the neural interface. Moreover, brain tissue heating from neural implants generated by the radiofrequency field from MRI poses potential hazards for patients. Previous studies with soft polymer‐based electrode arrays provide relatively suitable MRI compatibility but does not guarantee high‐resolution electrophysiological signal acquisition and stimulation performance. Here, MRI compatible, optically transparent flexible implantable device capable of electrophysiological multichannel mapping and electrical stimulation is introduced. Using the device, neuropathic pain (NP) relief with a 30‐channel electrophysiological mapping of the somatosensory area before and after motor cortex stimulation (MCS) in allodynia rats after noxious stimulation is confirmed. Additionally, artifact‐free manganese‐enhanced MRI of dramatic relief of pain‐related region activity by MCS is demonstrated. Furthermore, artifact‐free optogenetics with transgenic mice is also investigated by recording light‐evoked potentials. These results suggest a promising neuro‐prosthetic for analyzing and modulating spatiotemporal neurodynamic without MRI or optical modality resolution constraints.
Source: crossref · Quality: baseline

Research context

PolymersBiomaterials

OpenAlex topics: Neuroscience and Neural Engineering · Transcranial Magnetic Stimulation Studies · EEG and Brain-Computer Interfaces

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Electrical and Electronic Engineering Yonsei University Seoul 03722 Republic of Korea

Department of Physiology Yonsei University College of Medicine Seoul 03722 Republic of Korea

Department of Medical Science Brain Korea 21 Project Yonsei University College of Medicine Seoul 03722 Republic of Korea

Department of Engineering Science and Mechanics The Pennsylvania State University University Park PA 16802 USA

Center for Neural Engineering The Pennsylvania State University State College University Park PA 16802 USA

Department of Anatomy Yonsei University College of Medicine Seoul 03722 Republic of Korea

Electronic Device Laboratory School of Electrical and Electronic Engineering Yonsei University Seoul 03722 Republic of Korea

Department of Biomedical Sciences College of Medicine Korea University Seoul 02841 Republic of Korea

Brain Research Institute Yonsei University College of Medicine Seoul 03722 Republic of Korea

Department of Anatomy College of Medicine Korea University Seoul 02841 Republic of Korea

Department of Materials Science and Engineering The Pennsylvania State University State College University Park PA 16802 USA

Materials Research Institute The Pennsylvania State University State College University Park PA 16802 USA

Yonsei‐KIST Convergence Research Institute Yonsei University Seoul 03722 Republic of Korea

Funding

National Research Foundation of Korea

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