Multifunctional Hydroxyapatite Nanobelt Haystacks Integrated Neural Stem Cell Spheroid for Rapid Spinal Cord Injury Repair
Source abstract
Abstract
Abstract Due to the unwarranted lifespan and differentiation, applying neural stem cells (NSCs) in spinal cord injury (SCI) remains challenging. In this study, 3D bioactive hydroxyapatite (HAp) nanobelt haystack‐mouse NSC (mNSC) hybrid spheroids are customized in which the specific nanobelt haystack framework provided the structural function of hypoxia alleviation in the spherical core and biological process of neural differentiation promotion. Commodified with superparamagnetic ferroferric oxide (Fe3O4) nanoparticles and a polydopamine (PDA) coating, the HAp nanobelts are endowed with magnetic field‐driven properties and enhanced cell‐nanobelt adhesion. The engineered bioresponsive 3D nanobelt haystack‐mNSC hybrid spheroids effectively repair SCI in vivo, showing new potential for stem cell therapy by incorporating nanomaterials in 3D culture based on cell‐material interactions.
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Research context
OpenAlex topics: 3D Printing in Biomedical Research · Tissue Engineering and Regenerative Medicine · Graphene and Nanomaterials Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
State Key Laboratory of Crystal Materials Shandong University Jinan 250100 P. R. China
Department of Orthopaedics Qilu Hospital Cheeloo College of Medicine Shandong University Jinan 250012 P. R. China
Institute for Advanced Interdisciplinary Research (IAIR) University of Jinan Jinan 250022 P. R. China
Funding
Key Technology Research and Development Program of Shandong · National Natural Science Foundation of China
References (51)
Show source-provided references
1. 10.1155/2014/58627010.1155/2014/586270 ↗
2. 10.1038/nn.342510.1038/nn.3425 ↗
3. 10.1038/s41551-020-00634-410.1038/s41551-020-00634-4 ↗
4. 10.1038/s41467-021-22758-010.1038/s41467-021-22758-0 ↗
5. 10.1126/sciadv.aaz033010.1126/sciadv.aaz0330 ↗
6. 10.1038/s41467-021-26126-w10.1038/s41467-021-26126-w ↗
7. 10.1038/s41586-018-0467-610.1038/s41586-018-0467-6 ↗
8. 10.1016/j.biomaterials.2010.08.11310.1016/j.biomaterials.2010.08.113 ↗
9. 10.1038/s41586-018-0089-z10.1038/s41586-018-0089-z ↗
10. 10.1038/s41583-021-00496-y10.1038/s41583-021-00496-y ↗
11. 10.1073/pnas.110807710810.1073/pnas.1108077108 ↗
12. 10.3390/cells812162010.3390/cells8121620 ↗
13. 10.37175/stemedicine.v2i5.6710.37175/stemedicine.v2i5.67 ↗
14. 10.1126/sciadv.abn861410.1126/sciadv.abn8614 ↗
15. 10.1038/nmat335710.1038/nmat3357 ↗
16. 10.1126/sciadv.abj228110.1126/sciadv.abj2281 ↗
17. 10.1038/nature0704210.1038/nature07042 ↗
18. 10.1038/nrm.2017.10810.1038/nrm.2017.108 ↗
19. 10.1126/science.aau829910.1126/science.aau8299 ↗
20. 10.1016/j.compositesb.2021.10894410.1016/j.compositesb.2021.108944 ↗
21. 10.1002/adma.20210089510.1002/adma.202100895 ↗
22. 10.1039/C9TA12703H10.1039/C9TA12703H ↗
23. 10.1021/acs.bioconjchem.6b0054410.1021/acs.bioconjchem.6b00544 ↗
24. 10.1016/j.biomaterials.2019.11965210.1016/j.biomaterials.2019.119652 ↗
25. 10.1073/pnas.071216810510.1073/pnas.0712168105 ↗
26. 10.1038/s41563-021-01087-z10.1038/s41563-021-01087-z ↗
27. 10.1038/nrm362010.1038/nrm3620 ↗
28. 10.1016/j.biomaterials.2017.03.05010.1016/j.biomaterials.2017.03.050 ↗
29. 10.1007/s10571-007-9237-y10.1007/s10571-007-9237-y ↗
30. 10.1126/scisignal.abf668510.1126/scisignal.abf6685 ↗
31. 10.1371/journal.pone.005330710.1371/journal.pone.0053307 ↗
32. 10.3727/00000000778346467810.3727/000000007783464678 ↗
33. Huang L. · Stem Cells Int. · 2017 · 2017
34. 10.1016/j.lfs.2016.10.00410.1016/j.lfs.2016.10.004 ↗
35. 10.1126/scisignal.200206010.1126/scisignal.2002060 ↗
36. 10.1038/nmat453610.1038/nmat4536 ↗
37. 10.1038/nmat502010.1038/nmat5020 ↗
38. 10.1038/nmeth.228310.1038/nmeth.2283 ↗
39. 10.1126/sciadv.160103910.1126/sciadv.1601039 ↗
40. 10.1186/1478-811X-11-1210.1186/1478-811X-11-12 ↗
41. 10.1021/acs.nanolett.1c0270810.1021/acs.nanolett.1c02708 ↗
42. 10.1523/JNEUROSCI.23-01-00103.200310.1523/JNEUROSCI.23-01-00103.2003 ↗
43. 10.1038/ncomms633110.1038/ncomms6331 ↗
44. 10.1038/s41551-021-00744-710.1038/s41551-021-00744-7 ↗
45. 10.1002/adfm.20170142010.1002/adfm.201701420 ↗
46. 10.1038/s41467-020-17521-w10.1038/s41467-020-17521-w ↗
47. 10.1186/s13578-020-00413-310.1186/s13578-020-00413-3 ↗
48. 10.1038/nature0744310.1038/nature07443 ↗
49. 10.4161/cbt.3.2.61410.4161/cbt.3.2.614 ↗
50. 10.1016/j.biomaterials.2008.01.03710.1016/j.biomaterials.2008.01.037 ↗
51. 10.1016/j.neures.2019.07.00710.1016/j.neures.2019.07.007 ↗