Multimodal Antibacterial E‐Skin Patch Driven by Oxidative Stress for Real‐Time Wound‐Status Monitoring and Integrated Treatment of Chronic Wounds

Abstract Healing of chronic wounds becomes a global health issue due to increasing incidence and associated burdens, and therefore promoting tissue‐remodeling and monitoring wound‐status visually are of particular significance. Herein, an electronic‐skin patch (TENG‐gel) composed by polydimethylsiloxane/polytetrafluoroethylene film, eutectic gallium–indium (E‐GaIn), and quaternary chitosan/polyacrylamide/sodium alginate@molybdenum disulfide (MoS₂) nanosheet (H_QPS@MoS₂) composite hydrogel is assembled layer‐by‐layer. First, the TENG‐gel realizes multimodal antibacterial by integrating peroxidase‐like activity, photothermal therapy, and nano‐knife effect, which eliminates both Gram‐positive/negative bacteria with killing ratio of above 95%. Besides, electrical stimulation generated from the TENG‐gel promotes migration of fibroblasts after an incubation of 48 h by activating signaling pathways, and meanwhile accelerates vascularization by secreting different growth factors of CD31, VEGF, and TGF‐β. Through providing an ideal microenvironment for tissue repair, the TENG‐gel achieves 1.6‐fold new hair follicles and 2.4‐fold collagen deposition compared with those of the control group. More interestingly, dual temperature‐/strain‐sensing performance enables the TENG‐gel with capability of monitoring wound status or reminding external danger signals in real‐time dependent on variational electrical signals. Overall, unique advantages of such smart electronic‐skin patch provide a personalized medicine strategy for realizing tissue reconstruction and monitoring synchronously.