journal article·2024-10Open access

Synchronously Manipulating the D−A Interaction and Planarity in Semiconducting Polymers to Achieve 84.7% Photothermal Conversion Efficiency for NIR‐II Imaging‐Guided Tumor Therapy

Xiankun Hu, Qian Jia, Qiyu Fang, Chaoqi Song, Ruili Zhang, Ying Liang, Zhanglei Yang, Jinting Wu, Hongbo Li, Tingxing Zhao, Deping Zhao, Zhongliang Wang

Advanced Functional Materials· Volume 34· Issue 44

Abstract

Abstract Exploiting photothermal agents with second‐near‐infrared (NIR‐II, 1000−1700 nm) emission and a high photothermal conversion efficiency (PCE) is an appealing and challenging task. Herein, by simultaneously tailoring the D−A interaction and planarity in fluorophores, two donor‐acceptor (D−A) −type semiconducting polymers (SPs), T‐BTP and B‐BTP, are constructed. Compared with T‐BTP, B‐BTP shows increased intramolecular interactions and improved molecular planarity, leading to bathochromic‐shift absorption, NIR‐II emission, and high PCE. Notably, the B‐BTP NPs achieve a remarkable PCE of 84.7%, which is among the highest PCEs of SPs in NIR‐II fluorescence imaging‐guided photothermal therapy (PTT). Because of these promising features, B‐BTP NPs are successfully used in NIR‐II vascular imaging and cancer therapy. This study provides valuable guidelines for the development of high‐performance NIR‐II SPs.
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Research context

OpenAlex topics: Nanoplatforms for cancer theranostics · Photoacoustic and Ultrasonic Imaging · Analytical Chemistry and Sensors

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

School of Materials and Chemistry Southwest University of Science and Technology Mianyang Sichuan 621010 P. R. China

Lab of Molecular Imaging and Translational Medicine (MITM) Engineering Research Center of Molecular and Neuro Imaging Ministry of Education School of Life Science and Technology Xidian University & International Joint Research Center for Advanced Medical Imaging and Intelligent Diagnosis and Treatment Xi'an Shaanxi 710126 P. R. China

Department of Medical Oncology Shanghai Pulmonary Hospital Tongji University Medical School Cancer Institute School of Medicine Tongji University Shanghai China 200433

State Key Laboratory of Environment‐friendly Energy Materials Southwest University of Science and Technology Mianyang Sichuan 621010 P. R. China

Department of Thoracic Surgery Shanghai Pulmonary Hospital School of Medicine Tongji University Shanghai P. R. China 200433

Funding

National Key Research and Development Program of China · National Natural Science Foundation of China · China Postdoctoral Science Foundation · Fundamental Research Funds for the Central Universities · Science and Technology Commission of Shanghai Municipality · Natural Science Basic Research Program of Shaanxi Province

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