A Novel 3D‐Printed Bi‐Layer Cranial‐Brain Patch Promotes Brain Injury Repair and Bone Tissue Regeneration
Source abstract
Abstract
Abstract Traumatic brain injury (TBI), recognized as the world's most serious public health problem, currently lacks effective treatment options. The development of the patch has great clinical significance whether it is used as a skull implant material or TBI repair. In response to this critical health challenge, a novel 3D‐printed bi‐layer cranial‐brain patch (SMB6) with dual functionality, addressing both TBI repair and skull regeneration, is developed. In the first layer, the incorporation of high concentrations of mesoporous bioactive glass nanoparticles establishes a microenvironment for bone regeneration. Meanwhile, the second layer, comprised of methacrylated silk fibroin hydrogel, provides essential mechanical support for nanocell membrane vesicles loaded with macrophage colony‐stimulating factor and interleukin‐6. This innovative design aims to interrupt the cascade of secondary brain injury. In experimental models of TBI, SMB6 demonstrates remarkable efficacy in inhibiting brain edema, exerting therapeutic effects on blood vessels, nerves, and inflammation. Additionally, promising outcomes are observed in promoting bone regeneration in skull defect models. This work not only introduces a potential therapeutic patch for TBI‐related diseases but also provides novel insights for the clinical translation of cranial patches.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Traumatic Brain Injury and Neurovascular Disturbances · Bone Tissue Engineering Materials · Head and Neck Surgical Oncology
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Key Laboratory of Biomaterials of Guangdong Higher Education Institutes Key Laboratory of Regenerative Medicine of Ministry of Education Guangdong Provincial Engineering and Technological Research Centre for Drug Carrier Development Department of Biomedical Engineering Jinan University Guangzhou 510632 China
Head Dept. Oral and Maxillofacial Surgery Leiden University Medical Centre De Boelelaan Amsterdam 1117 The Netherlands
Key Laboratory of CNS Regeneration (Ministry of Education) Guangdong‐Hong Kong‐Macau Institute of CNS Regeneration Jinan University Guangzhou 510632 China
College of Life Science and Technology Jinan University 601 Huangpu Road Guangzhou 510632 China
Guangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications Institute of Photonics Technology Jinan University Guangzhou 511436 China
Department of Neurology The First Affiliated Hospital of Jinan University Guangzhou 510630 China
Department of Emergency The First Affiliated Hospital Sun Yat‐sen University Guangzhou 510080 China
Funding
National Key Research and Development Program of China · National Natural Science Foundation of China
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