DataVXAdvanced Functional MaterialsPaper
journal article·2024-07

A Mn2+‐Assisted Nanofiber‐Hydrogel Adjuvant for Simultaneous Enhancement of Humoral and Cellular Immune Responses

Haixue Jia, Jia Lin, Dianyu Wang, Xue Lv, Qian Wang, Zhongyan Wang, Jinjian Liu, Lijun Yang, Jianfeng Liu

Advanced Functional Materials· Volume 34· Issue 30
Publisher page
Source abstract

Abstract

Abstract Limited ability to elicit cellular immune responses has restricted the effectiveness of conventional adjuvants in the context of cancers. Recent advancements in innate immune activation mechanism investigations have paved the way for the implementation of a “bottom‐up” approach in the development of novel adjuvants. Herein, a simple hydrogel adjuvant with a uniformly organized nanoscale microstructure, termed MnPgel is devised, by employing self‐assembling peptides incorporated with manganese ions (Mn2+). MnPgel exhibits Mn2+ sustained‐release properties in vivo and effectively promotes germinal center formation, thereby facilitating the generation of antibodies at levels comparable to conventional aluminum‐based adjuvants. Moreover, MnPgel transcends the scope of humoral immunity, demonstrating the ability to robustly trigger cellular immune responses and positioning it as a promising candidate for cancer prevention and treatments. In conclusion, the work has introduced a well‐defined hydrogel adjuvant as a proof‐of‐concept, simplifying vaccine adjuvant design and opening up new avenues for “on‐demand” immunomodulation strategies.
Source: crossref · Quality: baseline

Research context

PolymersNanomaterials

OpenAlex topics: RNA Interference and Gene Delivery · Supramolecular Self-Assembly in Materials · Antimicrobial Peptides and Activities

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

State Key Laboratory of Advanced Medical Materials and Devices Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine Key Laboratory of Radiopharmacokinetics for Innovative Drugs Tianjin Institutes of Health Science Institute of Radiation Medicine Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin 300192 P. R. China

State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood Diseases Haihe Laboratory of Cell Ecosystem Institute of Hematology & Blood Diseases Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin 300020 China

Tianjin Institutes of Health Science Tianjin 300020 P. R. China

Funding

National Natural Science Foundation of China · Fundamental Research Funds for the Central Universities · Chinese Academy of Medical Sciences Initiative for Innovative Medicine · China National Funds for Distinguished Young Scientists

References (54)

Show source-provided references
1. WHO Vaccines and immunization https://www.who.int/data/gho/data/themes/immunization.
2. 10.1038/s41568-021-00346-010.1038/s41568-021-00346-0 ↗
3. 10.1038/s41392-023-01557-710.1038/s41392-023-01557-7 ↗
4. 10.1007/978-1-0716-1892-9_810.1007/978-1-0716-1892-9_8 ↗
5. 10.1038/s41586-021-03530-210.1038/s41586-021-03530-2 ↗
6. 10.1016/j.coi.2013.12.00710.1016/j.coi.2013.12.007 ↗
7. 10.1038/s41423-021-00726-410.1038/s41423-021-00726-4 ↗
8. 10.1016/j.immuni.2023.07.01810.1016/j.immuni.2023.07.018 ↗
9. 10.1038/s41573-021-00163-y10.1038/s41573-021-00163-y ↗
10. 10.3390/pharmaceutics1302014210.3390/pharmaceutics13020142 ↗
11. 10.4049/jimmunol.230002610.4049/jimmunol.2300026 ↗
12. 10.1016/j.immuni.2016.02.00410.1016/j.immuni.2016.02.004 ↗
13. 10.3389/fcimb.2021.74501610.3389/fcimb.2021.745016 ↗
14. 10.1016/j.celrep.2020.10805310.1016/j.celrep.2020.108053 ↗
15. 10.1038/s41423-021-00669-w10.1038/s41423-021-00669-w ↗
16. 10.1016/j.jtbi.2016.02.00610.1016/j.jtbi.2016.02.006 ↗
17. 10.1039/b915765b10.1039/b915765b ↗
18. Tse J. R. · Curr Protoc Cell Biol · 2010 · 10 · 16
19. 10.1073/pnas.191365511710.1073/pnas.1913655117 ↗
20. 10.1016/j.chempr.2023.04.02310.1016/j.chempr.2023.04.023 ↗
21. 10.3389/fmolb.2017.0008710.3389/fmolb.2017.00087 ↗
22. 10.1016/j.jconrel.2018.04.03110.1016/j.jconrel.2018.04.031 ↗
23. 10.1126/sciadv.aba099510.1126/sciadv.aba0995 ↗
24. 10.1038/s41577-019-0210-z10.1038/s41577-019-0210-z ↗
25. 10.1016/j.immuni.2018.03.01710.1016/j.immuni.2018.03.017 ↗
26. 10.1126/science.125786110.1126/science.1257861 ↗
27. 10.1038/s41578-021-00372-210.1038/s41578-021-00372-2 ↗
28. 10.1038/nri286810.1038/nri2868 ↗
29. 10.1146/annurev-med-121217-09423410.1146/annurev-med-121217-094234 ↗
30. 10.1126/science.abe150210.1126/science.abe1502 ↗
31. 10.1038/s41577-022-00784-310.1038/s41577-022-00784-3 ↗
32. 10.1056/NEJMcibr210605410.1056/NEJMcibr2106054 ↗
33. 10.1186/s40064-015-0972-010.1186/s40064-015-0972-0 ↗
34. 10.1038/s41591-020-0753-310.1038/s41591-020-0753-3 ↗
35. 10.1002/EXP.2021026310.1002/EXP.20210263 ↗
36. 10.1038/s41577-020-0391-510.1038/s41577-020-0391-5 ↗
37. 10.1038/nri324710.1038/nri3247 ↗
38. 10.1016/j.molcel.2019.07.01610.1016/j.molcel.2019.07.016 ↗
39. Gutjahr A. · JCI Insight · 2019 · 4
40. 10.1038/s41590-021-00896-310.1038/s41590-021-00896-3 ↗
41. 10.1016/j.celrep.2018.11.04710.1016/j.celrep.2018.11.047 ↗
42. 10.1038/s41467-022-33301-010.1038/s41467-022-33301-0 ↗
43. 10.1093/nar/gkaa08410.1093/nar/gkaa084 ↗
44. 10.1021/acs.nanolett.2c0497010.1021/acs.nanolett.2c04970 ↗
45. 10.1016/j.bioactmat.2023.11.01710.1016/j.bioactmat.2023.11.017 ↗
46. 10.1038/s41565-023-01401-710.1038/s41565-023-01401-7 ↗
47. 10.1073/pnas.091212410710.1073/pnas.0912124107 ↗
48. 10.1016/j.cej.2022.13478210.1016/j.cej.2022.134782 ↗
49. 10.1021/acsbiomaterials.7b0048810.1021/acsbiomaterials.7b00488 ↗
50. 10.1002/adma.20200331010.1002/adma.202003310 ↗
51. 10.1002/adma.20230145510.1002/adma.202301455 ↗
52. 10.1038/s41587-019-0390-x10.1038/s41587-019-0390-x ↗
53. 10.1002/EXP.2021015310.1002/EXP.20210153 ↗
54. 10.1038/s41586-022-05216-910.1038/s41586-022-05216-9 ↗