HAp Thermosensitive Nanohydrogel Cavities Act as Brood Pouches to Incubate and Control‐Release NSCs for Rapid Spinal Cord Injury Therapy
Source abstract
Abstract
Abstract Limitations such as the cell life span, cellular activity, and cellular diffusion outside the lesion make the direct repair of spinal cord injury (SCI) by neural stem cell (NSC) transplantation challenging. Here, an injectable hydroxyapatite (HAp) thermosensitive nanohydrogel is proposed to achieve stem cell storage and release, as well as fate regulation, for therapy. The cavities formed in situ functioned as brood pouches for cell proliferation. The enzyme‐induced collapse of cavities released mouse NSCs (mNSCs) gradually and continuously. The endocytosis of HAp nanorods by encapsulated mNSCs enhanced the property of mNSC neuronal differentiation. The HAp thermosensitive nanohydrogel with mNSCs exert an inspiring therapeutic effect on a complete transected SCI model and has prospects in material design to improve SCI therapy with stem cells.
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Research context
OpenAlex topics: Nerve injury and regeneration · Graphene and Nanomaterials Applications · Hydrogels: synthesis, properties, applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
State Key Laboratory of Crystal Materials Shandong University Jinan 250100 China
Department of Orthopedics Qilu Hospital Cheeloo College of Medicine Shandong University Jinan 250012 China
Tianjin Key Laboratory of Spine and Spinal Cord Injury Tianjin Medical University General Hospital Tianjin 300052 China
Institute for Advanced Interdisciplinary Research (IAIR) University of Jinan Jinan 250022 China
Funding
National Key Research and Development Program of China · National Natural Science Foundation of China
References (49)
Show source-provided references
1. 10.1038/s41582-019-0280-310.1038/s41582-019-0280-3 ↗
2. 10.1002/adma.20210242810.1002/adma.202102428 ↗
3. 10.1002/adma.20180686110.1002/adma.201806861 ↗
4. 10.1038/s41467-021-22758-010.1038/s41467-021-22758-0 ↗
5. 10.1038/nature0934710.1038/nature09347 ↗
6. 10.1038/sj.cr.731014110.1038/sj.cr.7310141 ↗
7. 10.1186/1478-811X-11-1210.1186/1478-811X-11-12 ↗
8. 10.1021/acs.nanolett.9b0398010.1021/acs.nanolett.9b03980 ↗
9. P.Rebellato Ph.D. Thesis Karolinska Institutet Stockholm Sweden2013.
10. 10.1111/j.1469-7793.2001.t01-1-00657.x10.1111/j.1469-7793.2001.t01-1-00657.x ↗
11. 10.1002/adma.20210089510.1002/adma.202100895 ↗
12. 10.1016/j.compositesb.2021.10894410.1016/j.compositesb.2021.108944 ↗
13. 10.1038/s41467-018-06941-410.1038/s41467-018-06941-4 ↗
14. 10.1016/j.carbpol.2019.11551610.1016/j.carbpol.2019.115516 ↗
15. 10.1002/adma.20060003310.1002/adma.200600033 ↗
16. 10.1016/j.carbpol.2018.01.00810.1016/j.carbpol.2018.01.008 ↗
17. 10.1038/ncomms1564610.1038/ncomms15646 ↗
18. 10.1038/nature0706110.1038/nature07061 ↗
19. 10.1038/nbt.150210.1038/nbt.1502 ↗
20. 10.1038/s41467-021-22871-010.1038/s41467-021-22871-0 ↗
21. 10.1038/ncb260310.1038/ncb2603 ↗
22. 10.1038/s41593-018-0285-z10.1038/s41593-018-0285-z ↗
23. 10.1126/sciadv.abf560610.1126/sciadv.abf5606 ↗
24. 10.1126/sciadv.abj228110.1126/sciadv.abj2281 ↗
25. 10.1038/nmeth.228310.1038/nmeth.2283 ↗
26. 10.1126/science.abg846710.1126/science.abg8467 ↗
27. 10.1038/nmat453610.1038/nmat4536 ↗
28. 10.1038/nmat502010.1038/nmat5020 ↗
29. 10.1126/scitranslmed.aay685310.1126/scitranslmed.aay6853 ↗
30. 10.1126/science.aav975010.1126/science.aav9750 ↗
31. 10.1126/sciadv.abd371610.1126/sciadv.abd3716 ↗
32. 10.1002/adfm.20130130710.1002/adfm.201301307 ↗
33. 10.1038/nmat504310.1038/nmat5043 ↗
34. 10.1038/natrevmats.2016.7110.1038/natrevmats.2016.71 ↗
35. 10.1038/s41392-021-00830-x10.1038/s41392-021-00830-x ↗
36. 10.1038/s41467-020-17749-610.1038/s41467-020-17749-6 ↗
37. 10.1038/s41419-021-04041-810.1038/s41419-021-04041-8 ↗
38. 10.1038/s41582-018-0010-210.1038/s41582-018-0010-2 ↗
39. 10.1016/j.biomaterials.2013.02.00210.1016/j.biomaterials.2013.02.002 ↗
40. 10.1016/j.biomaterials.2019.01.01210.1016/j.biomaterials.2019.01.012 ↗
41. 10.1002/adfm.20210291210.1002/adfm.202102912 ↗
42. 10.1016/j.expneurol.2020.11338110.1016/j.expneurol.2020.113381 ↗
43. 10.1089/neu.2013.309610.1089/neu.2013.3096 ↗
44. 10.1007/s12015-010-9152-310.1007/s12015-010-9152-3 ↗
45. 10.1021/acsnano.9b0759810.1021/acsnano.9b07598 ↗
46. 10.1002/advs.20190124010.1002/advs.201901240 ↗
47. Li J. · Nat. Methods · 2020 · 6
48. 10.1038/s41583-020-0264-810.1038/s41583-020-0264-8 ↗
49. 10.1634/stemcells.2008-012110.1634/stemcells.2008-0121 ↗