journal article·2024-07

Tuning Molecular Packing by Twisting Structure to Facilely Construct Highly Efficient Solid‐State Fluorophores for Two‐Photon Bioimaging and Photodynamic Therapy

Hui Cao, Ya Gao, Bingshun Wu, Jianyu Zhang, Lianke Wang, Peifa Wei, Lijie Liu, Hang Zou, Hongping Zhou, Zheng Zheng, Ben Zhong Tang

Advanced Functional Materials· Volume 34· Issue 27
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Abstract

Abstract The traditional design strategy for constructing highly bright solid‐state luminescent materials relies on incorporating aggregation‐induced emission (AIE) scaffolds, molecular rotors, or bulky substituents to prevent close cofacial packing, which limits the strategy diversity in developing new materials. Herein, a strategy of tuning molecular packing by twisting molecular structure of conventional aggregation‐caused quenching fluorophore is proposed to endow materials with AIE effect and enhance the solid‐state fluorescence. Accordingly, a series of 1,4‐bis(diphenylamino)‐2,5‐disubstituted benzene fluorophores exhibiting AIE characteristics, high solid‐state fluorescence efficiency (up to 0.99), wide emission color tunability, and good near‐infrared (NIR) two‐photon absorption is facilely developed. All these luminogens can specifically stain intracellular lipid droplets with a high signal‐to‐noise ratio, high biocompatibility, and good photostability. Besides, the luminogens exhibit effective reactive oxygen species (ROS) generation capability upon low‐power white light irradiation. Among them, the AIE luminogen, named BDBDC, integrating the NIR emission, good NIR two‐photon absorption and strongest ROS generation demonstrates superior performances in two‐photon fluorescence imaging of various tissues and photodynamic cancer therapy. This molecular design philosophy provides a new way of designing highly bright solid‐state fluorophores for practical applications.
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Research context

OpenAlex topics: Luminescence and Fluorescent Materials · Nanoplatforms for cancer theranostics · Molecular Sensors and Ion Detection

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

School of Chemistry and Chemical Engineering Hefei University of Technology Hefei 230009 P. R. China

Department of Laboratory Medicine Nanfang Hospital Southern Medical University Guangzhou 510515 P. R. China

Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction State Key Laboratory of Molecular Neuroscience Division of Life Science Ming Wai Lau Centre for Reparative Medicine Karolinska Institute and Guangdong‐Hong Kong‐Macau Joint Laboratory of Optoelectronic and Magnetic Functional Materials The Hong Kong University of Science and Technology Kowloon Hong Kong 999077 P. R. China

Institutes of Physical Science and Information Technology Anhui University Hefei 230031 P. R. China

College of Science Henan Agricultural University 63 Agricultural Road Zhengzhou Henan 450002 P. R. China

School of Chemical and Environmental Engineering Anhui Polytechnic University Wuhu 230036 P. R. China

School of Chemistry and Chemical Engineering Key Laboratory of Functional Inorganic Materials Chemistry of Anhui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials of Anhui Province Key Laboratory of Structure and Functional Regulation of Hybrid Materials (Anhui University) Ministry of Education Anhui University Hefei 230601 P. R. China

School of Science and Engineering The Chinese University of Hong Kong Shenzhen (CUHK‐Shenzhen) Guangdong 518172 P. R. China

Funding

National Natural Science Foundation of China · Fundamental Research Funds for the Central Universities · Science, Technology and Innovation Commission of Shenzhen Municipality

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