DataVXAdvanced Functional MaterialsPaper
journal article·2023-08

Magnetic Hydrogel Microrobots Delivery System for Deafness Prevention

Hong Chen, Hui Zhang, Yanhong Dai, Haofang Zhu, Guodong Hong, Chengwen Zhu, Xiaoyun Qian, Renjie Chai, Xia Gao, Yuanjin Zhao

Advanced Functional Materials· Volume 33· Issue 35
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Source abstract

Abstract

Abstract Hydrogel microrobots have blazed new avenues for local drug administration, while their values in inner ear drug delivery remain to be explored. Here, novel magnetic alpha‐lipoic acid (ALA)‐conjugated gelatin methacryloyl hydrogel microrobots are presented for inner ear drug delivery and deafness prevention. The magnetic hydrogel microrobots with features of slow drug release, targeted movement, and biosafety are generated from microfluidic devices. After intratympanic injection, the microrobots can be oriented in the middle ear cavity under a specific magnetic field. In addition, the ALA drug released from the magnetic hydrogel microrobots can remain in the inner ear for a long time. Based on these advantages, the practical value of the magnetic hydrogel microrobots in deafness prevention is demonstrated by pre‐injecting them in the middle ear of cisplatin‐deafened mice. These results indicate that the proposed smart magnetic hydrogel microrobots can effectively deliver drugs to the inner ear through the middle ear drug delivery route, thus opening a new chapter for middle ear deafness treatment.
Source: crossref · Quality: baseline

Research context

Polymers

OpenAlex topics: Micro and Nano Robotics · Modular Robots and Swarm Intelligence · Advanced Sensor and Energy Harvesting Materials

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Otolaryngology Head and Neck Surgery Research Institute of Otolaryngology Nanjing Drum Tower Hospital Jiangsu Provincial Key Medical Discipline Affiliated Hospital of medical School, Nanjing University Nanjing 210008 China

State Key Laboratory of Digital Medical Engineering Department of Otolaryngology Head and Neck Surgery Zhongda Hospital School of Life Sciences and Technology Advanced Institute for Life and Health Jiangsu Province High‐Tech Key Laboratory for Bio‐Medical Research Southeast University Nanjing 210096 China

Co‐Innovation Center of Neuroregeneration, Nantong University, Nantong 226001, China Nantong University No. 9, Qiyuan Road, Chongchuan District, Nantong City, Jiangsu Province Nantong 226001 China

Department of Rheumatology and Immunology The First Affiliated Hospital of Anhui Medical University Hefei 230022 China

Funding

National Natural Science Foundation of China · Natural Science Foundation of Jiangsu Province

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