DataVXAdvanced Functional MaterialsPaper
journal article·2023-05

Metal‐Coordinated Adsorption of Nanoparticles to Macrophages for Targeted Cancer Therapy

Mao‐Hua Zhu, Xin‐Di Zhu, Mei Long, Xing Lai, Yihang Yuan, Yanhu Huang, Lele Zhang, Yuhao Gao, Jiangpei Shi, Qin Lu, Peng Sun, Jonathan F. Lovell, Hong‐Zhuan Chen, Chao Fang

Advanced Functional Materials· Volume 33· Issue 19
Publisher page
Source abstract

Abstract

Abstract Living cell‐based drug delivery systems (LC‐DDSs) are limited by adverse interactions between drugs and carrier cells, typically drug‐induced toxicity to carrier cells and restriction of carrier cells on drug release. Here, a method is established to adsorb nanocarriers externally to living cells, thereby reducing cytotoxicity caused by drug uptake and realizing improved drug release at the disease site. It is found that a divalent metal ion‐phenolic network (MPN) affords adhesion of poly (lactic‐co‐glycolic acid) nanoparticles onto macrophage (Mφ) surfaces with minimized intracellular uptake and no negative effect on cell proliferation. On this basis, an Mφ‐DDS with doxorubicin‐loaded nanoparticles on cell surface (DOX‐NP@Mφ) is constructed. Compared to intracellular loading via endocytosis, this method well‐maintains bioactivity (viability and migration chemotaxis) of the carrier cell. By virtue of the photothermal effect of MPN at the tumor site, DOX‐NP‐associated vesicles are liberated for improved chemotherapy. This facile, benign, and efficient method (ice bath, 2 min) for extracellular nanoparticle attachment and minimizing intracellular uptake provides a platform technology for LC‐DDS development.
Source: crossref · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · Nanoparticle-Based Drug Delivery · Extracellular vesicles in disease

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Hongqiao International Institute of Medicine Tongren Hospital and State Key Laboratory of Oncogenes and Related Genes Department of Pharmacology and Chemical Biology Shanghai Jiao Tong University School of Medicine (SJTU‐SM) Shanghai 200025 China

Department of Pharmacy Shanghai Ninth People's Hospital, SJTU‐SM Shanghai 200011 China

Department of General Surgery Tongren Hospital, SJTU‐SM Shanghai 200336 China

Department of Biomedical Engineering University at Buffalo State University of New York Buffalo NY 14260 USA

Institute of Interdisciplinary Integrative Biomedical Research Shuguang Hospital Shanghai University of Traditional Chinese Medicine Shanghai 201203 China

Key Laboratory of Basic Pharmacology of Ministry of Education & Joint International Research Laboratory of Ethnomedicine of Ministry of Education Zunyi Medical University Zunyi 563003 China

Funding

National Natural Science Foundation of China · Program of Shanghai Academic Research Leader · Science and Technology Commission of Shanghai Municipality

References (54)

Show source-provided references
1. 10.1038/s41587-022-01245-x10.1038/s41587-022-01245-x ↗
2. 10.1038/s41587-020-0462-y10.1038/s41587-020-0462-y ↗
3. 10.1158/2159-8290.CD-20-055610.1158/2159-8290.CD-20-0556 ↗
4. 10.1016/j.jconrel.2014.03.05010.1016/j.jconrel.2014.03.050 ↗
5. 10.1016/j.addr.2016.04.02110.1016/j.addr.2016.04.021 ↗
6. 10.1016/j.jconrel.2017.01.04810.1016/j.jconrel.2017.01.048 ↗
7. 10.1016/j.tips.2020.11.00810.1016/j.tips.2020.11.008 ↗
8. 10.1038/s41551-018-0310-210.1038/s41551-018-0310-2 ↗
9. 10.1016/j.jconrel.2020.08.06310.1016/j.jconrel.2020.08.063 ↗
10. 10.1016/j.ejca.2019.10.02010.1016/j.ejca.2019.10.020 ↗
11. 10.1158/1078-0432.CCR-20-095010.1158/1078-0432.CCR-20-0950 ↗
12. 10.1111/bjh.1815210.1111/bjh.18152 ↗
13. 10.1002/adma.20100407410.1002/adma.201004074 ↗
14. 10.1002/adma.20180555710.1002/adma.201805557 ↗
15. 10.1002/adma.20200205410.1002/adma.202002054 ↗
16. 10.1021/acsami.9b2363210.1021/acsami.9b23632 ↗
17. 10.1016/j.mattod.2020.05.02310.1016/j.mattod.2020.05.023 ↗
18. 10.1016/j.addr.2022.11413610.1016/j.addr.2022.114136 ↗
19. 10.1002/adma.20220778710.1002/adma.202207787 ↗
20. 10.1021/acsnano.0c0629010.1021/acsnano.0c06290 ↗
21. 10.1021/nl072209h10.1021/nl072209h ↗
22. 10.1021/acsnano.5b0558310.1021/acsnano.5b05583 ↗
23. 10.1002/adma.20170624510.1002/adma.201706245 ↗
24. 10.1126/scirobotics.aaz951910.1126/scirobotics.aaz9519 ↗
25. 10.1038/nnano.2017.5410.1038/nnano.2017.54 ↗
26. 10.1002/anie.20170657010.1002/anie.201706570 ↗
27. 10.1038/nm.219810.1038/nm.2198 ↗
28. 10.1126/scitranslmed.aaz666710.1126/scitranslmed.aaz6667 ↗
29. 10.1126/scitranslmed.aaa544710.1126/scitranslmed.aaa5447 ↗
30. 10.1002/adhm.20200137510.1002/adhm.202001375 ↗
31. 10.1021/acs.biomac.1c0048810.1021/acs.biomac.1c00488 ↗
32. 10.1016/j.ymthe.2017.08.01010.1016/j.ymthe.2017.08.010 ↗
33. 10.1002/adma.20200002010.1002/adma.202000020 ↗
34. 10.1002/adfm.20180184010.1002/adfm.201801840 ↗
35. 10.1021/jacs.7b0844010.1021/jacs.7b08440 ↗
36. 10.1126/sciadv.aaz657910.1126/sciadv.aaz6579 ↗
37. 10.1016/j.biomaterials.2017.06.01710.1016/j.biomaterials.2017.06.017 ↗
38. 10.1038/nbt.418110.1038/nbt.4181 ↗
39. 10.1038/nnano.2016.17210.1038/nnano.2016.172 ↗
40. 10.1021/acs.nanolett.0c0029510.1021/acs.nanolett.0c00295 ↗
41. 10.1021/jacs.1c0975310.1021/jacs.1c09753 ↗
42. 10.1002/adma.20210578310.1002/adma.202105783 ↗
43. 10.1002/adma.20200349210.1002/adma.202003492 ↗
44. 10.1126/science.702265410.1126/science.7022654 ↗
45. 10.1002/anie.20200208910.1002/anie.202002089 ↗
46. 10.1002/adma.20210862410.1002/adma.202108624 ↗
47. 10.1016/S2352-3026(21)00134-410.1016/S2352-3026(21)00134-4 ↗
48. 10.1002/anie.20131113610.1002/anie.201311136 ↗
49. 10.1016/j.cub.2021.01.03610.1016/j.cub.2021.01.036 ↗
50. 10.1021/acs.nanolett.7b0233010.1021/acs.nanolett.7b02330 ↗
51. 10.1021/acsnano.8b0145610.1021/acsnano.8b01456 ↗
52. 10.1038/s41571-020-0410-210.1038/s41571-020-0410-2 ↗
53. 10.1073/pnas.152208011310.1073/pnas.1522080113 ↗
54. 10.1007/s40820-021-00666-810.1007/s40820-021-00666-8 ↗