Biopolymer Nanovehicles for Oral Delivery of Natural Anticancer Agents

Seid Reza Falsafi; Yong Wang; Tolulope Joshua Ashaolu; Minaxi Sharma; Shruti Rawal; Kaushika Patel; Gholamreza Askari; Shaghayegh Haghjooy Javanmard; Hadis Rostamabadi

doi:10.1002/adfm.202209419

journal article·2023-01

Biopolymer Nanovehicles for Oral Delivery of Natural Anticancer Agents

Seid Reza Falsafi, Yong Wang, Tolulope Joshua Ashaolu, Minaxi Sharma, Shruti Rawal, Kaushika Patel, Gholamreza Askari, Shaghayegh Haghjooy Javanmard, Hadis Rostamabadi

Advanced Functional Materials· Volume 33· Issue 4

Publisher page

Source abstract

Abstract

Abstract Cancer is the second leading cause of death throughout the world. Nature‐inspired anticancer agents (NAAs) that are a gift of nature to humanity have been extensively utilized in the alleviation/prevention of the disease due to their numerous pharmacological activities. While the oral route is an ideal and common way of drug administration, the application of NAAs through the oral pathway has been extremely limited owing to their inherent features, e.g., poor solubility, gastrointestinal (GI) instability, and low bioavailability. With the development of nano‐driven encapsulation strategies, polymeric vehicles, especially those with natural origins, have demonstrated a potent platform, which can professionally shield versatile NAAs against GI barricades and safely deliver them to the site of action. In this review, the predicament of orally delivering NAAs and the encapsulation strategy solutions based on biopolymer matrices are summarized. Proof‐of‐concept in vitro/in vivo results are also discussed for oral delivery of these agents by various biopolymer vehicles, which can be found so far from the literature. Last but not the least, the challenges and new opportunities in the field are highlighted.

Source: crossref · Quality: baseline

Research context

Polymers Nanomaterials

OpenAlex topics: Nanoparticle-Based Drug Delivery · Advanced Drug Delivery Systems · Drug Solubulity and Delivery Systems

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Isfahan Endocrine and Metabolism Research Center Isfahan University of Medical Sciences Isfahan 81746‐73461 Iran

School of Chemical Engineering UNSW Sydney Sydney NSW 2052 Australia

Institute of Research and Development Duy Tan University Da Nang 550000 Viet Nam

Faculty of Environmental and Chemical Engineering Duy Tan University Da Nang 550000 Viet Nam

Laboratoire de Chimie verte et Produits Biobasés Haute Ecole Provinciale de Hainaut‐Condorcet Département AgroBioscience et Chimie 11, Rue de la Sucrerie 7800 ATH Belgium

Department of Applied Biology University of Science and Technology Ri‐Bhoi Meghalaya 793101 India

Department of Pharmaceutical Technology L.J. Institute of Pharmacy L J University Ahmedabad 382210 India

Department of Pharmaceutics Institute of Pharmacy Nirma University S.G. Highway, Chharodi Ahmedabad Gujarat 382481 India

Department of Community Nutrition School of Nutrition and Food Science Nutrition and Food Security Research Center Isfahan University of Medical Sciences Isfahan 81746‐73461 Iran

Applied Physiology Research Center Cardiovascular Research Institute Isfahan University of Medical Isfahan 81746‐73461 Iran

Nutrition and Food Security Research Center Isfahan University of Medical Sciences Isfahan 81746‐73461 Iran

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