Magneto‐Mechano‐Electric Cascade Stimulation System Accelerates Wound Healing Constructed by Biodegradable Magnetoelectric Nanofibers

Abstract Reconstructing the intricate biophysical microenvironment to provide multiple biologically beneficial stimulation is deemed a promising therapeutic strategy. However, developing multi‐biophysical stimuli with wireless integration and accurate management remains a formidable challenge. Herein, a novel design of a magneto‐mechano‐electric (MME) cascade stimulation system based on aligned magnetoelectric nanofibrous membranes (PLLA/CFO) is reported. Simply regulating the loading amount of CFO nanoparticles endows the PLLA/CFO membranes with excellent magnetism, enhanced crystallization, and resultant piezoelectric responsiveness, thus providing built‐in topographical guidance and nanoscale magnetic field as well as manageably remote stimulation. Specifically, assisted by an external magnetic field (EMF), the magnetic response in PLLA/CFO can be amplified to offer an apparent deformation, which then induces the output of mechanical and electrical cues. Benefiting from the slow degradability of PLLA and continuous EMF triggering, such a performance can be well modulated to match the practical wound healing process, demonstrated by the repair of a rat full‐thickness skin defect. More importantly, this work offers a new strategy to reconstruct the complex biophysical microenvironment in a wireless remote manner.