journal article·2023-09

Engineered Bicomponent Adhesives with Instantaneous and Superior Adhesion Performance for Wound Sealing and Healing Applications

Kelu Zhao, Bo Li, Yao Sun, Bo Jia, Jing Chen, Wenhao Cheng, Lai Zhao, Jingjing Li, Fan Wang, Juanjuan Su, Jing Sun, Bing Han, Yawei Liu, Hongjie Zhang, Kai Liu

Advanced Functional Materials· Volume 33· Issue 38
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Abstract

Abstract Surgical adhesives are playing an important role in wound repair and emergency hemostasis in clinical treatment. However, the development of strong bioglue with rapid in situ adhesion, durable adhesiveness, and flexibility in dynamic and moist physiological environments is still challenging. Herein, a new type of biosynthetic protein bioadhesives with superior adhesion performance is reported by developing a protein aldimine condensation strategy. Lysine‐rich recombinant proteins are designed and massively biosynthesized to instantaneously react with aldehyde cross‐linkers to realize in situ strong adhesion. The obtained bioadhesives show an ultra‐high adhesion strength of ≈101.6 kPa on porcine skin, outperforming extant clinical bioglues. In addition, they possess super biocompatibility, flexibility, biodegradability, and compliance with the tissues. Owing to the strong and instantaneous adhesion properties, the bioadhesives are qualified for dynamic wound closure, facilitating wound repair, and noncompressible hemorrhage. Importantly, they can be industrially encapsulated into custom‐made cartridge delivery tubes at low cost for clinical use. Therefore, biosynthetic bioadhesives have great potential for biological applications and are capable of scaling up to the industrial level for clinical transformation, which will be a successful paradigm for reforming existing clinical products.
Source: crossref · Quality: baseline

Research context

OpenAlex topics: Surgical Sutures and Adhesives · Hemostasis and retained surgical items · Polymer Surface Interaction Studies

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China

University of Science and Technology of China Hefei 230026 China

Engineering Research Center of Advanced Rare Earth Materials Ministry of Education Department of Chemistry Tsinghua University Beijing 100084 China

Xiangfu Laboratory Jiaxing Zhejiang 314102 China

College of Materials Science and Opto‐Electronic Technology University of Chinese Academy of Sciences Beijing 100049 China

School of Chemistry and Molecular Engineering Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development East China Normal University Shanghai 200062 China

Department of Orthodontics Cranial‐Facial Growth, and Development Center Peking University School and Hospital of Stomatology and National Center of Stomatology and National Clinical Research Center for Oral Diseases and National Engineering Laboratory for Digital and Material Technology of Stomatology 22 Zhongguancun South Avenue, Haidian District Beijing 100081 China

Funding

Natural Science Foundation of Jilin Province · National Natural Science Foundation of China · China Postdoctoral Science Foundation

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