journal article·2024-01Open access

Superior Synergistic Osteogenesis of MXene‐Based Hydrogel through Supersensitive Drug Release at Mild Heat

Ying Chen, Wenwen Liu, Sijie Wan, Huagao Wang, Yumin Chen, Han Zhao, Chenguang Zhang, Kaihui Liu, Tuanfeng Zhou, Lei Jiang, Qunfeng Cheng, Xuliang Deng

Advanced Functional Materials· Volume 34· Issue 2

Abstract

Abstract Near‐infrared (NIR) responsive smart drug delivery systems could provide efficient osteogenesis through the synergy of heat and drugs. However, such systems are hampered by an inability to allow supersensitive drug release through mild heat. Here superior osteogenesis is demonstrated using a biocompatible dexamethasone (Dex)‐loaded MXene‐poly(N‐isopropylacrylamide)‐co‐N‐(Hydroxymethyl) acrylamide hydrogel capable of the supersensitive release of Dex at ≈42 °C upon NIR irradiation. Furthermore, the hydrogel can significantly promote bone regeneration under NIR irradiation due to the synergistic anti‐apoptosis and osteogenic differentiation of bone‐derived mesenchymal stem cells induced by the mild heat and supersensitive release of Dex. The resulting osteogenesis efficiency of hydrogels surpass efficiencies previously reported for heat and drug stimulation and their combination. The synergistic osteogenesis strategy is characterized by near‐instantaneous, noninvasive, and precise treatment through temporal NIR irradiation.
Source: crossref · Quality: baseline

Research context

OpenAlex topics: MXene and MAX Phase Materials · Nanoplatforms for cancer theranostics · Graphene and Nanomaterials Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

The First Clinical Division Peking University School and Hospital of Stomatology Beijing 100034 China

Department of Geriatric Dentistry Peking University School and Hospital of Stomatology & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices Beijing 100081 China

School of Chemistry Key Laboratory of Bio‐inspired Smart Interfacial Science and Technology of Ministry of Education Beihang University Beijing 100191 China

Hospital of Stomatology Sun Yat‐sen University Guangdong Provincial Key Laboratory of Stomatology Guangzhou 510000 China

School of Physics Peking University Beijing 100871 China

School of Chemistry and Materials Science University of Science and Technology of China Hefei 230026 China

Suzhou Institute for Advanced Research University of Science and Technology of China Suzhou 215123 China

Institute of Energy Materials Science (IEMS) University of Shanghai for Science and Technology Shanghai 200093 China

Funding

National Key Research and Development Program of China · National Natural Science Foundation of China · National Postdoctoral Program for Innovative Talents · China Postdoctoral Science Foundation · Fundamental Research Funds for the Central Universities

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