journal article·2025-08Open access

Biomimetic Piezoelectric Periosteum‐Bone Integrated Implant Promotes Bone Defect Repair by Remodeling Osteogenic Microenvironment

Xiaokun Yue, Xueheng Sun, Zilin Li, Tianchang Wang, Weiqing Kong, Shuai Li, Jing Shan, Hao Yang, Weize Kong, Wentao Li, Changru Zhang, Bin Cai, Kerong Dai, Yuxin Zhang, Xin Sun, Jinwu Wang

Advanced Functional Materials· Volume 35· Issue 35

Abstract

Abstract Bone defects caused by trauma, infection, or tumors pose significant clinical challenges, particularly in large defects with poor healing outcomes. Traditional repair methods often fail to address the complex regenerative microenvironment. This study introduces a novel biomimetic piezoelectric periosteum‐bone bilayer implant designed to remodel the osteogenic microenvironment and enhance bone defect repair. The implant comprises an upper electrospun polyvinylidene fluoride‐curcumin‐loaded magnesium metal–organic framework (PVDF‐MOF/Cur, PMC) periosteum scaffold and a lower hydroxyapatite@gelatin methacrylate (HA@GelMA) bone scaffold (PMC+HA@GelMA, PMCG). In the whole PMCG bilayer implant, the upper PMC periosteum scaffold improves the piezoelectric properties of PVDF and enables sustained drug release via Mg‐MOF loaded with Cur. Meanwhile, the lower HA@GelMA scaffold facilitates bone marrow mesenchymal stem cells osteogenic differentiation and bone regeneration. Additionally, the upper PMC scaffold further accelerates bone repair by promoting neuronal differentiation, as well as enhancing angiogenesis and regulating macrophage polarization. Transcriptome sequencing reveals that the implant activates key signaling pathways associated with angiogenesis, neurogenesis, inflammation regulation, and osteogenesis, including HIF‐1α, PI3K‐Akt, JAK‐STAT, and TGF‐β pathways. Thus, this work highlights the multifunctional capabilities of the biomimetic periosteum‐bone bilayer implant to remodify the osteogenic microenvironment to accelerate bone defect repair, which offers a promising platform for advancing tissue repair.
Source: crossref · Quality: baseline

Research context

OpenAlex topics: Bone Tissue Engineering Materials · Electrospun Nanofibers in Biomedical Applications · 3D Printing in Biomedical Research

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Shanghai Key Laboratory of Orthopedic Implant Department of Orthopedic Surgery Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine No. 639 Zhizaoju Road Shanghai 200011 China

Department of Sport Rehabilitation Shanghai University of Sport Shanghai 200438 China

Department of Orthopedic Surgery Xuzhou Central Hospital Xuzhou Clinical School of Xuzhou Medical University 199 Jiefang South Road Xuzhou 221009 China

Department of Orthopedics The First Affiliated Hospital Zhejiang University School of Medicine 79 Qingchun Rd Hangzhou 310003 China

The University of Sydney Faculty of Medicine and Health School of Pharmacy Pharmacy and Bank Building A15 Sydney NSW 2006 Australia

Sports Medicine Department Beijing Key Laboratory of Sports Injuries Peking University Third Hospital No.49, North Garden Road, Haidian District Beijing 100191 China

Department of Oral Surgery Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine College of Stomatology Shanghai Jiao Tong University National Center for Stomatology National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of Stomatology Shanghai 200011 China

Department of Orthopaedics Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine No. 600 Yishan Road Shanghai 200233 China

Funding

National Key Research and Development Program of China · National Natural Science Foundation of China

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